Fluorescence Endoscopy With 5-Aminolevulinic Acid Reduces Early Recurrence Rate in Superficial Bladder Cancer

Abstract

ALA fluorescence endoscopy is an innocuous and inexpensive diagnostic procedure that significantly improves bladder tumor detection rates compared to standard white light endoscopy. In our controlled study ALA fluorescence endoscopy reduced the residual tumor detection rate at second look transurethral resection by 59%.

Feasibility of Photodynamic Diagnosis for Challenging TUR-Bt Cases Including Muscle Invasive Bladder Cancer, BCG Failure or 2nd-TUR

“…(Riedl et al, 2001;Zaak et al, 2001;Daniltchenko et al, 2005) Most of the previous studies test the pTa, maximally pT1 NMIBC patients. However no studies so far specifically used PDD for 2nd-TUR for muscle invasive bladder cancer (MIBC) and for BCG failure.…”

Update on the management of non-muscle invasive bladder cancer

“…50,51 This is performed by pre-instilling 5-aminolevulinic acid or hexylaminolaevulinate in the bladder 30 to 60 minutes prior to using ultraviolet/blue light cystoscopy. The substance accumulates in malignant cells, which can be easily identified with blue light cystoscopy.…”

The Current Diagnosis of Superficial Bladder Cancer Must Be Reconsidered

“…Therefore, a decrease of the recurrence rate is expected together with an increase in the interval until recurrent disease takes place. First results have shown so far that there might be a significant influence on the early recurrence rates [32,33]. Meanwhile, a prospective, randomized multicenter trial is in progress to evaluate the magnitude of the long-term effects of the fluorescence-guided resection as compared with the standard white-light approach.…”