Fluorescence‐based sensor for selective and sensitive detection of amoxicillin (Amox) in aqueous medium: Application to pharmaceutical and biomedical analysis

Pawar, Samadhan P.; Walekar, Laxman S.; Gunjal, Dattatray B.; Dalavi, Dattatray K.; Gore, Anil H.; Anbhule, Prashant V.; Patil, Shivajirao R.; Kolekar, Govind B.

doi:10.1002/bio.3271

Cited by 21 publications

(5 citation statements)

References 25 publications

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“…S. P. Pawar et al . demonstrated AMX determination method based on the fluorescence quenching of quantum dots (QDs). The developed method has been successfully applied for the determination of amoxicillin in pharmaceutical formulations and urine samples with acceptable results.…”

Section: Introductionsupporting

confidence: 89%

Sensitive Voltammetric Amoxicillin Sensor Based on TiO₂ Sol Modified by CMK‐3‐type Mesoporous Carbon and Gold Ganoparticles

et al. 2018

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In this work, a novel voltammetric sensor was developed to determine amoxicillin (AMX). The electrode modification layer consisted of titanium dioxide sol (TiO2) modified with gold nanoparticles (AuNPs), CMK‐3‐type mesoporous carbon and Nafion. The morphology of the electrode composite was studied by scanning electron microscopy (SEM). Electrochemical behaviour of AMX at proposed electrode was studied. Effects of parameters comprising the amount of CMK‐3 and AuNPs in matrix composite, pH of supporting electrolyte and incubation time on the sensitivity of developed sensor were examined. The analytical characteristics of the proposed sensor were assessed. The developed sensor exhibited linear response in two AMX concentration ranges: from 0.5 to 2.5 μM and from 2.5 to 133.0 μM, with sensitivity of 1420 μA mM−1 (5071 μA mM−1 cm−2) and 832 μA mM−1 (2971 μA mM−1 cm−2), respectively. The detection limit was evaluated as 0.3 μM. For verification purposes the sensor was successfully employed in determination of AMX in pharmaceutical product, mineral and environmental water using a flow‐batch monosegmented sequential injection approach.

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Section: Introductionsupporting

confidence: 89%

Sensitive Voltammetric Amoxicillin Sensor Based on TiO₂ Sol Modified by CMK‐3‐type Mesoporous Carbon and Gold Ganoparticles

et al. 2018

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“…25−27 Innovative combinations of known components may lead to the development of multifunctional materials that provides superior composite material with possible applications in various fields such as catalysis, electronics, biosensing, drug delivery, nanomedicine, and environmental remediation, to name a few. 28 Until now, many reports used carbon dots in aqueous medium; however incorporating them into a gel matrix offers rigidity and stability that results in the outstanding properties of hybrid material. Cayuela et al reported the mixing of functionalized carbon nanodots into a low molecular weight salt hydrogel that exhibited a sensor response toward Pb 2+ .…”

Section: Introductionmentioning

confidence: 99%

Nitrogen-Doped Carbon Dots via Hydrothermal Synthesis: Naked Eye Fluorescent Sensor for Dopamine and Used for Multicolor Cell Imaging

Naik

Zantye

Gunjal

et al. 2019

ACS Appl. Bio Mater.

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The development of a novel uncomplicated sensor for sensitive and selective detection in biomedical analysis is necessary. This study demonstrates the preparation of nitrogen-doped carbon dots (NC dots) via hydrothermal synthesis as a naked eye fluorescent probe for selective and sensitive detection of dopamine (DA). The successful synthesis of NC dots was confirmed using various microscopic and spectroscopic techniques. In addition, NC-dot-incorporated gel strips were prepared through a simple approach for naked eye detection of dopamine. The linear range for detection of dopamine was 2−20 μg/mL with a detection limit as low as 1.97 μg/mL. Moreover, NC dots showed a low toxicity toward HeLa cells, demonstrating their relevance in multicolor cell imaging. The developed probe was also utilized for quantitative determination of dopamine in a commercial pharmaceutical sample with adequate results.

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“…Furthermore, Pawar et al synthesized mercaptopropionic acid‐capped (MPA) cadmium sulfide (CdS) QDs and used the fluorescence quenching of the QD method to detect AMX in pharmaceutical formulations and urine samples. [ 41 ] The change in fluorescence intensity of QDs was recognized by the cumulative concentration of AMX. The obtained results confirmed that the fluorescence quenching of QDs showed a linear response with the AMX concentration.…”

Section: Optical Sensors For Amx Detectionmentioning

confidence: 99%

Nanostructured material‐based optical and electrochemical detection of amoxicillin antibiotic

et al. 2022

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The penicillin derivative amoxicillin (AMX) plays an important role in treating various types of infections caused by bacteria. However, excessive use of AMX may have negative health effects. Therefore, it is of utmost importance to detect and quantify the AMX in pharmaceutical drugs, biological fluids, and environmental samples with high sensitivity. Therefore, this review article provides valuable and up‐to‐date information on nanostructured material‐based optical and electrochemical sensors to detect AMX in various biological and chemical samples. The role of using different nanostructured materials on the performance of important optical sensors such as colorimetric sensors, fluorescence sensors, surface‐enhanced Raman scattering sensors, chemiluminescence/electroluminescence sensors, optical immunosensors, optical fibre‐based sensors, and several important electrochemical sensors based on different electrode types have been discussed. Moreover, nanocomposites, polymer, and MXenes‐based electrochemical sensors have also been discussed, in which such materials are being used to further enhance the sensitivity of these sensors. Furthermore, nanocomposite‐based photo‐electrochemical sensors and the market availability of biosensors including AMX have also been discussed briefly. Finally, the conclusion, challenges, and future perspectives of the above‐mentioned sensing techniques for AMX detection are presented.

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Fluorescence‐based sensor for selective and sensitive detection of amoxicillin (Amox) in aqueous medium: Application to pharmaceutical and biomedical analysis

Cited by 21 publications

References 25 publications

Sensitive Voltammetric Amoxicillin Sensor Based on TiO₂ Sol Modified by CMK‐3‐type Mesoporous Carbon and Gold Ganoparticles

Sensitive Voltammetric Amoxicillin Sensor Based on TiO₂ Sol Modified by CMK‐3‐type Mesoporous Carbon and Gold Ganoparticles

Nitrogen-Doped Carbon Dots via Hydrothermal Synthesis: Naked Eye Fluorescent Sensor for Dopamine and Used for Multicolor Cell Imaging

Nanostructured material‐based optical and electrochemical detection of amoxicillin antibiotic

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Fluorescence‐based sensor for selective and sensitive detection of amoxicillin (Amox) in aqueous medium: Application to pharmaceutical and biomedical analysis

Cited by 21 publications

References 25 publications

Sensitive Voltammetric Amoxicillin Sensor Based on TiO2 Sol Modified by CMK‐3‐type Mesoporous Carbon and Gold Ganoparticles

Sensitive Voltammetric Amoxicillin Sensor Based on TiO2 Sol Modified by CMK‐3‐type Mesoporous Carbon and Gold Ganoparticles

Nitrogen-Doped Carbon Dots via Hydrothermal Synthesis: Naked Eye Fluorescent Sensor for Dopamine and Used for Multicolor Cell Imaging

Nanostructured material‐based optical and electrochemical detection of amoxicillin antibiotic

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Sensitive Voltammetric Amoxicillin Sensor Based on TiO₂ Sol Modified by CMK‐3‐type Mesoporous Carbon and Gold Ganoparticles

Sensitive Voltammetric Amoxicillin Sensor Based on TiO₂ Sol Modified by CMK‐3‐type Mesoporous Carbon and Gold Ganoparticles