Fluorescence‐advanced videodermatoscopy: A promising and potential technique for the in vivo evaluation of vitiligo

Scarfì, Federica; Gori, Alessia; Silvestri, Flavia; Trane, Luciana; Portelli, Francesca; Maida, Pierandrea; Dika, Emi; Broganelli, Paolo; Massi, Daniela; Giorgi, Vincenzo De

doi:10.1111/dth.12863

Cited by 4 publications

(15 citation statements)

References 7 publications

(8 reference statements)

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“…For repigmented skin areas, FAV reveals a proliferation of pigmented cells at the dermal‐epidermal junction. These findings indicate that FAV has similar potential to RCM for disease staging and therapeutic monitoring in patients with vitiligo 23 …”

Section: Fluorescence‐advanced Videodermatoscopymentioning

confidence: 63%

“…FAV is an optical electronic system consisting of a handheld probe and a monochromatic lightemitting source with a λ of 405 nm (±5 nm) and a fixed angle of incidence. 22,23 In normal conditions, FAV provides optical penetration depth varying from 200 μm to 400 μm and allows the visualization of subcutaneous structures to the point below the papillary dermis. 22 To prevent light diffusion on the corneum stratus, glycerol is applied to the skin surface.…”

Section: Fluore Scen Ce-advan Ced Videodermatoscopymentioning

confidence: 99%

“…Fluorescence‐advanced videodermatoscopy (FAV) has recently been proposed as a new type of VD instrument for in vivo skin evaluation at ×12 primary magnification (Table 4). FAV is an optical electronic system consisting of a handheld probe and a monochromatic light‐emitting source with a λ of 405 nm (±5 nm) and a fixed angle of incidence 22,23 . In normal conditions, FAV provides optical penetration depth varying from 200 μm to 400 μm and allows the visualization of subcutaneous structures to the point below the papillary dermis 22 .…”

Section: Fluorescence‐advanced Videodermatoscopymentioning

confidence: 99%

“…The working mechanism underlying FAV exists in the ability of endogenous molecules to emit fluorescence after absorbing specific wavelengths. 23 The fluorescence intensity is expressed as the grayscale of images (black, no fluorescence; white, highest fluorescence), reflecting the absorption levels of a specific skin structure. FAV is particularly suitable for studying structures and cells containing melanin or hemoglobin.…”

Section: Fluore Scen Ce-advan Ced Videodermatoscopymentioning

confidence: 99%

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Recent developments in dermoscopy for dermatology

Chen

et al. 2020

J of Cosmetic Dermatology

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Background: Dermoscopy is considered to be a bridge between clinical observation and histopathological examination, allowing the in vivo examination of skin microstructures that are not visible to the naked eye, from the epidermis to the superficial dermis. Dermoscopy has undergone rapid development, witnessing the history from natural light to polarized light, from handheld dermoscopy to videodermoscopy, and from classic dermoscopy to digital dermoscopy. Its application extends from the initial differential diagnosis of pigmented skin diseases (melanocytic and nonmelanocytic) to general dermatology, including appendage (nail and hair) abnormalities and diseases related to infection and inflammation. Aims:We aimed to provide the latest developments in dermoscopy from the perspective of handheld dermoscopy, videodermoscopy, fluorescence-advanced videodermatoscopy, polarized transilluminating dermoscopy, and digital dermoscopy. Methods:In this review, we searched the PubMed, Embase, Web of Science, and Cochrane Library databases for reviews, case reports, and observational studies on dermoscopy. Results:We provided an updated review of dermoscopy based on published literature. Conclusion:Dermoscopy is an indispensable diagnostic tool in dermatology, and it is expected to be further developed in the future.

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Section: Fluorescence‐advanced Videodermatoscopymentioning

confidence: 63%

Section: Fluore Scen Ce-advan Ced Videodermatoscopymentioning

confidence: 99%

Section: Fluorescence‐advanced Videodermatoscopymentioning

confidence: 99%

Section: Fluore Scen Ce-advan Ced Videodermatoscopymentioning

confidence: 99%

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Recent developments in dermoscopy for dermatology

Chen

et al. 2020

J of Cosmetic Dermatology

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“…10 The optical penetration depth varies from 200 to 400 lm, allowing multiple transverse scans of the skin layers, up to the papillary dermis. 13 Fluorescence advanced videodermoscopy resulted particularly useful for the study of melanocytic lesions, vascular lesions and skin parasitosis. [10][11][12][13][14][15][16] This is the first work applying this new technique for the study of the scalp.…”

Section: Discussionmentioning

confidence: 99%

Fluorescence advanced videodermoscopy: a new method of hairs and scalp evaluation. Comparison with trichoscopy.

Rossi

Magri

Caro

et al. 2021

Acad Dermatol Venereol

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Introduction Non-invasive diagnostic methods in clinical dermatology are widely used to reduce the need for invasive techniques, with great advantages in terms of cost and time. Dermoscopy is the reference test for the in vivo diagnosis of cutaneous lesions, and when it is performed on the scalp region it is named trichoscopy. Fluorescence advanced videodermoscopy (FAV) has been lately proposed as a new non-invasive method for the in vivo skin examination at high magnification, with cell-level resolution. So far, it has shown promising results for the assessment of melanocytic and vascular lesions and for the in vivo diagnosis of parasitosis.Objectives This observational study aims to perform, for the first time, a morphologic study of healthy scalp and scalp elementary lesions using FAV and to compare it with trichoscopy. Methods We enrolled 90 healthy individuals for the evaluation of the scalp using FAV. Then, we recruited 53 patients with alopecia and collected images of the elementary lesions using FAV and trichoscopy.Results Three hundred healthy scalp FAV images of different epidermal layers, papillary dermis, follicular ostia and healthy hair shafts were collected. Three hundred and eighty FAV and trichoscopic images of alopecic scalp elementary lesions were collected, showing that FAV provided a more detailed observation than trichoscopy, with higher magnification and cellular resolution. ConclusionFluorescence advanced videodermoscopy may represent a new valid technique of support to trichoscopy, adding further information, increasing chances of diagnosis and decreasing the need of invasive procedures.

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Fluorescence‐advanced videodermatoscopy (FAV) for the differential diagnosis of suspicious facial lesions: A single‐centre experience with pattern analysis and histopathological correlation

Scarfì

Trane

Maio

et al. 2021

Photoderm Photoimm Photomed

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Background: Fluorescence-advanced videodermatoscopy (FAV) is a new non-invasive high-resolution skin imaging technique to assess pigmented lesions in conjunction with the clinical examination and dermatoscopy.Objectives: This is the first prospective study to identify morphologic descriptors and standardized terminology to examine facial pigmented lesions using FAV. The objectives were to identify FAV indicators, which can assist physicians in diagnosing suspicious flat facial pigmented lesions.Methods: Consecutive equivocal pigmented lesions were retrospective analysed.Histopathological examination was performed for all the lesions. The main cytomorphological and cytoarchitectural FAV features were described and correlated with histopathological characteristics.Results: From January to October 2020, 21 consecutive clinically suspected pigmented lesions in 20 patients were analysed using dermatoscopy and FAV and then surgically excised. Histopathological examination identified lentigo maligna (LM), lentigo maligna melanoma (LMM), solar lentigo (SL), flat seborrheic keratosis (SK) and pigmented actinic keratosis (PAK). Thirteen malignant melanocytic lesions were removed (11 LM, 2 LMM), two were diagnosed as PAK, and the remaining six pigmented lesions were SL-SKs. With FAV, large ovoid pleomorphic and dendritic cells arranged in the intrafollicular disposition, are typical of most malignant melanocytic lesions (12/13, 92.3%). No benign lesions displayed these features. In dermatoscopy, this folliculotropism corresponded to the presence of an annular-granular pattern with slate grey dots that were aggregated asymmetrically around follicular openings.Conclusions: FAV features can provide an improved diagnostic approach in the differential diagnosis of flat pigmented facial lesions.

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Fluorescence‐advanced videodermatoscopy: A promising and potential technique for the in vivo evaluation of vitiligo

Cited by 4 publications

References 7 publications

Recent developments in dermoscopy for dermatology

Recent developments in dermoscopy for dermatology

Fluorescence advanced videodermoscopy: a new method of hairs and scalp evaluation. Comparison with trichoscopy.

Fluorescence‐advanced videodermatoscopy (FAV) for the differential diagnosis of suspicious facial lesions: A single‐centre experience with pattern analysis and histopathological correlation

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