Fluorescence accompanying methanolysis of β‐lactam antibiotics

Navarro, Pablo; Bekkouri, A. El; Reinoso, E. Rodríguez

doi:10.1002/(sici)1099-0801(199904)13:2<105::aid-bmc855>3.0.co;2-#

Cited by 5 publications

(2 citation statements)

References 2 publications

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“…Beside hydrolysis, methanolysis of β‐lactam antibiotics is also of importance and methanolysis of amoxicillin and ampicillin has been studied . Figure shows the ESI‐CID‐MS/MS spectra of ions [ Amox methanolyz + H] + and [ Amp methanolyz + H] + ( m/z 398 and 382).…”

Section: Resultsmentioning

confidence: 99%

Electrospray ionization collision‐induced dissociation tandem mass spectrometry of amoxicillin and ampicillin and their degradation products

Frański

Czerniel

Kowalska

et al. 2014

Rapid Comm Mass Spectrometry

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The discussion presented enables a better understanding of the MS decompositions of amoxicillin and ampicillin as well as their degradation products. MS decomposition is used for the determinations of these compounds, when the so-called multiple-reaction monitoring is applied during liquid chromatography (LC)/ESI-MS analysis. Thus, better understanding of MS decompositions of the above compounds seems to be important.

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Section: Resultsmentioning

confidence: 99%

Electrospray ionization collision‐induced dissociation tandem mass spectrometry of amoxicillin and ampicillin and their degradation products

Frański

Czerniel

Kowalska

et al. 2014

Rapid Comm Mass Spectrometry

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“…Besides hydrolysis, methanolysis of β-lactam antibiotics is also a very common process widely studied in detail. 1–6 Methanolysis of β-lactam antibiotics catalysed by metal cations has been studied in detail. 7–10 Methanolysis of β-lactam antibiotics occurs very easily in the presence of methanol, already at room temperature, and it may be the undesired process from the analytical point of view.…”

Section: Introductionmentioning

confidence: 99%

Comparison of the electrospray ionization (ESI) responses of penicillins with ESI responses of their methanolysis products

Podniesińska

Frański

Frańska

2018

Eur J Mass Spectrom (Chichester)

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The electrospray ionization (ESI) responses, defined as the area of chromatographic peak of ion [M+H]+ obtained upon HPLC/ESI-MS analysis, of three β-lactam antibiotics, namely penicillin G, ampicillin and carbenicillin have been compared with the ESI responses of their methanolysis products. It has been found that methanolyzed penicillin G has much higher ESI response than the penicillin G. Methanolyzed ampicillin also has higher ESI response than ampicillin; however, the effect is less pronounced than for penicillin. Methanolyzed carbenicillin does not have pronouncedly higher ESI response than carbenicillin.

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Electrochemical determination of Cephalothin antibiotic by adsorptive stripping voltammetric technique

Al-Ghamdi

Alshadokhy

Al–Warthan

2004

Journal of Pharmaceutical and Biomedical Analysis

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Fluorescence accompanying methanolysis of β‐lactam antibiotics

Cited by 5 publications

References 2 publications

Electrospray ionization collision‐induced dissociation tandem mass spectrometry of amoxicillin and ampicillin and their degradation products

Electrospray ionization collision‐induced dissociation tandem mass spectrometry of amoxicillin and ampicillin and their degradation products

Comparison of the electrospray ionization (ESI) responses of penicillins with ESI responses of their methanolysis products

Electrochemical determination of Cephalothin antibiotic by adsorptive stripping voltammetric technique

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