Fluorescein angiography and adverse drug reactions revisited: the Lions Eye experience

Kwan, Anthony; Barry, Chris; McAllister, Ian L.; Constable, Ian J.

doi:10.1111/j.1442-9071.2006.01136.x

Cited by 158 publications

(115 citation statements)

References 40 publications

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“…Serious adverse reactions are extremely rare but are known to occur. 7 Yannuzzi et al 8 estimated the risk of death following FFA to be 1:222 000. Minor adverse reactions are not uncommon.…”

Section: Introductionmentioning

confidence: 99%

The diagnostic accuracy of spectral-domain optical coherence tomography for neovascular age-related macular degeneration: a comparison with fundus fluorescein angiography

Wilde

Patel²,

Lakshmanan

et al. 2015

Eye

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Section: Introductionmentioning

confidence: 99%

The diagnostic accuracy of spectral-domain optical coherence tomography for neovascular age-related macular degeneration: a comparison with fundus fluorescein angiography

Wilde

Patel²,

Lakshmanan

et al. 2015

Eye

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“…Nausea rates of 0.7% (3) , 2.9% (4) and 6.83% were found (1) . In another study the subgroup of diabetic patients experienced the highest nausea rate in more than 15% of the angiograms (5) , but hypertensive and elderly patients did not show increase in such reactions (6) .…”

Section: Discussionmentioning

confidence: 99%

Anafilaxia com convulsões após angiografia com fluoresceína em paciente ambulatorial

Balbino

Silva

2012

Einstein (São Paulo)

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Fluorescein is associated with minor adverse effects during retinal angiography, and most of these effects are not severe and not related to immunological mechanism. However, on rare occasions, anaphylatoid reaction can occur, and fatalities involving fluorescein have been described. Life threatening complications after intravenous injection of sodium fluorescein require immediate intervention. Trainings for professionals are needed to standardize treatment for this event.Keywords: Anaphylaxis; Seizures/chemically induced; Fluorescein angiography/adverse effects; Fluoresceins/administration & dosage; Retinal diseases; Injections, intravenous; Case reports RESUMO A fluoresceína endovenosa é associada a pequenos efeitos adversos durante a angiografia da retina, a maioria deles sem gravidade e não relacionada a mecanismos imunológicos. Entretanto, em raras ocasiões, pode ocorrer reação anafilactoide; fatalidades envolvendo o uso de fluoresceína têm sido descritas. Complicações graves após injeção endovenosa de fluoresceína requerem ação imediata da equipe envolvida, assim como treinamento regular para padronizar o tratamento.

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“…According to the available published literature, anaphylactic shock in response to intravenous fluorescein administration during eye fundus angiography is an extremely rare complication (1 out of 22,000 patients). Allergy established in the anamnesis of several patients and need in a diagnostic trial implied prescription of desensitizing therapy [6,7]. According to other data, allergic reactions resulting in cardiopulmonary failure have never been registered at confocal laser endomicroscopy.…”

Section: Resultsmentioning

confidence: 99%

Intravenous Fluorescein Administration Safety at Confocal Laser Endomicroscopy of Gastrointestinal Tract in Children

Alexandrov¹,

Шавров²,

Kharitonova³

et al. 2013

Pediatr. farmakol.

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Confocal laser endomicroscopy (CLE) is a method of optic biopsy, which allows obtaining histologic presentation of mucous tunic in real time IntroductionDetailed visualization of the digestive tract's mucous tunic is necessary for early diagnostics of a disease. Probe-based confocal laser endomicroscopy (pCLE) is a new method of gastrointestinal endoscopy, which yields images of mucous tunic of ca. 1 micron resolution and visualizes cellular and subcellular structures, capillaries and singular blood cells. The available published data indicate high interconnection of confocal endomicroscopy intravital images with the traditional histology of the unaltered digestive tract's mucous tunic [1,2]. The technique allows quickly differentiating between an inflamed, metaplastic or dysplastic mucous tunic; without any doubt, this increases interest in the use of this technique in clinical practice for diagnosis of such diseases as Barrett esophagus, gastric metaplasia of esophagus, neoplasms, inflammatory diseases of large and small intestines, Helicobacter pylori, celiac disease etc. It should be noted, that it is necessary to administer a diagnostic agent intravenously in order to obtain high-contrast images at pCLE of digestive tract. 10% sodium fluorescein solution may be used; it is widely applied in diagnostic practice in adult patients [2,3]. In 2008, the Ministry of Health of the RF approved intravenous fluorescein administration for evaluation of eye fundus condition using a confocal laser ophthalmoscope (Registration number LRS-000829/08 of 18.02.08); the procedure itself appeared to be of excellent safety level in pediatric ophthalmology [3]. This study is relevant due to the lack of direct indication in the world pediatric practice to intravenous administration of this pCLE-required diagnostic agent.

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Fluorescein angiography and adverse drug reactions revisited: the Lions Eye experience

Cited by 158 publications

References 40 publications

The diagnostic accuracy of spectral-domain optical coherence tomography for neovascular age-related macular degeneration: a comparison with fundus fluorescein angiography

The diagnostic accuracy of spectral-domain optical coherence tomography for neovascular age-related macular degeneration: a comparison with fundus fluorescein angiography

Anafilaxia com convulsões após angiografia com fluoresceína em paciente ambulatorial

Intravenous Fluorescein Administration Safety at Confocal Laser Endomicroscopy of Gastrointestinal Tract in Children

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