Fluorescein Angiographic Features of Asymptomatic Eyes in Central Serous Chorioretinopathy

Abstract

Considerable number of asymptomatic eyes had features suggestive of healed or chronic subclinical CSC. These eyes are at risk for CSC caused by occurrence of active leak(s) from the same or new site(s).

Morphological changes in the retinal pigment epithelium on spectral-domain OCT in the unaffected eyes with idiopathic central serous chorioretinopathy

“…Fluorescein angiography of the asymptomatic eyes has been reported to show diffuse leak, indicating decompensation of the RPE in 7.14% and other changes in 45% of the asymptomatic eyes [4]. Sixteen percent of the patients in that series developed an episode of ICSC in the previously asymptomatic eye during follow-up, indicating the propensity of RPE to decompensate [4]. Indocyanine green angiography (ICG) demonstrated unequivocal bilaterality in many of the studies [23][24][25][26].…”

“…Keywords Central serous chorioretinopathy Á Idiopathic central serous retinopathy Á Spectral domain Á Optical coherence tomography Idiopathic central serous chorioretinopathy (ICSC) is a disease of young and middle-aged adults that frequently manifests symptomatically in one eye, while 5-18% of cases may be bilateral at time of presentation [1][2][3][4]. Several reports on fluorescein and indocyanine green angiography and multifocal electroretinography indicate that the disease process in ICSC is more diffuse and shows bilateral retinochoroidal dysfunction, even though the disease may be manifesting clinically only in one eye [4][5][6][7][8].…”

“…Several reports on fluorescein and indocyanine green angiography and multifocal electroretinography indicate that the disease process in ICSC is more diffuse and shows bilateral retinochoroidal dysfunction, even though the disease may be manifesting clinically only in one eye [4][5][6][7][8]. Though the etiology of ICSC remains unknown, it is postulated that the abnormalities in choroidal circulation make overlying retinal pigment epithelium (RPE) dysfunctional, resulting in the development of serous retinal detachment [7,9,10].…”

Central serous chorioretinopathy: Recent findings and new physiopathology hypothesis

“…In an analysis of 74 cases, 4% presented bilateral CSCR at the time of diagnosis, 8% of unilateral cases had either a history of CSCR or FA findings indicative of CSCR in the contralateral eye, and 9% of patients initially diagnosed with unilateral disease developed CSCR in the other eye during follow-up (Kitzmann et al, 2008). In a retrospective case series of 229 patients, 32% of asymptomatic fellow eyes presented fluorescein angiographic features indicating healed or subclinical CSCR, including SRD, PEDs, depigmented or atrophic RPE patches, drusen-like deposits, or pigment clumps (Bujarborua et al, 2005).…”

Choroidal Thickness in Both Eyes of Patients with Unilateral Central Serous Chorioretinopathy

“…The abnormal increase in the thickness of choroid in apparently normal fellow eye of case group indicates that CSCR must essentially be a systemic disorder affecting both eyes at the choroidal level [14,15]. In cross sectional studies [16,17] the CSCR clinically and simultaneously involves both eyes with frequency ranging from 4 to 14% cases. However, in 20 to 30% cases bilaterality is reported when follow up was done for a long period of time [18].…”