Fluor‑carbonated hydroxyapatite coatings by pulsed laser deposition to promote cell viability and antibacterial properties

Hidalgo-Robatto, Bettiana Marcela; Aguilera-Correa, John Jairo; López‐Álvarez, Miriam; Romera, David; Esteban, Jaime; González, P.; Serra, J.

doi:10.1016/j.surfcoat.2018.06.047

Cited by 25 publications

(19 citation statements)

References 61 publications

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“…Investigated compositions include

{CO}_{3}^{2 -}

/F − /Cl − /Na + /Mg 2+ /K + , Mg 2+ /Ni + /

{SiO}_{4}^{4 -}

, Sb 3+ /Mn 2+ /F − /Cl − , Sr 2+ /Mg 2+ /Mn 2+ , Mg 2+ /Zn 2+ /Co 2+ , Zn 2+ /Ag + /Au 2+ , Ag + /Zn 2+ /Mg 2+ /Sr 2+ , and

{CO}_{3}^{2 -}

/F − /Na + /Mg 2+ co‐substitutions.…”

Section: Multi‐substituted Hydroxyapatite Powders and Coatingsmentioning

confidence: 99%

“…Further multi‐substituted HAp coatings, mainly based on F − /

{CO}_{3}^{2 -}

co‐doping, were deposited on titanium implants by Hidalgo‐Robatto et al through pulsed laser deposition (PLD), using fluorapatite from the shark teeth enameloid as a target. They evidenced that the final composition and crystalline phases of the produced films strictly depended on H 2 O vapour pressures applied during PLD: higher pressure values led to increased crystallinity, lower crystallite sizes and a more efficient compositional transference from the target (with the possibility to also transfer some minor elements, eg Na and Mg, in addition to Ca, P and F), and promoted the carbonate groups and H 2 O incorporation with consequent Ca/P ratio decrease to values of around 1.800.…”

Section: Multi‐substituted Hydroxyapatite Powders and Coatingsmentioning

confidence: 99%

“…They evidenced that the final composition and crystalline phases of the produced films strictly depended on H 2 O vapour pressures applied during PLD: higher pressure values led to increased crystallinity, lower crystallite sizes and a more efficient compositional transference from the target (with the possibility to also transfer some minor elements, eg Na and Mg, in addition to Ca, P and F), and promoted the carbonate groups and H 2 O incorporation with consequent Ca/P ratio decrease to values of around 1.800. For example, applying a H 2 O pressure of 0.35‐0.45 mbar, the original fluorapatite (with small contributions of tricalcium bis(orthophosphate) and/or whitlockite) of the shark tooth enameloid became a hydrated fluorinated carbonated hydroxyapatite …”

Section: Multi‐substituted Hydroxyapatite Powders and Coatingsmentioning

confidence: 99%

“…Similarly, Hidalgo‐Robatto et al investigated the biological performances of multi‐substituted HAp coatings, mainly based on F − /

{CO}_{3}^{2 -}

co‐dopants, carrying out in vitro tests with MC3T3‐E1 pre‐osteoblasts and bacterial strains Staphylococcus aureus and Staphylococcus epidermidis , responsible for 77% of infections associated with prosthetic implants. The collected experimental evidences confirmed the doped coatings antibacterial properties, detecting a significant reduction in colony‐forming units (CFUs) for both strains with respect to undoped coatings, due to the fluorine incorporation.…”

Section: Multi‐substituted Hydroxyapatite Powders and Coatingsmentioning

confidence: 99%

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Multisubstituted hydroxyapatite powders and coatings: The influence of the codoping on the hydroxyapatite performances

Cacciotti

2019

Int J Applied Ceramic Tech

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The biological apatite, whose the bone and teeth mineral phases are composed, remarkably differs from stoichiometric hydroxyapatite (HAp, Ca10(PO4)6(OH)2, Ca/P = 1.667). Indeed, it consists in carbonated Ca‐deficient (Ca/P < 1.667) apatite, characterised by the presence of several vicarious ions, either incorporated within the apatite lattice or just adsorbed on the crystal surface, including anionic (eg, F−, Cl−, SiO44- and CO3=) and/or cationic substitutions (eg, Na+, Mg2+, K+, Sr2+, Zn2+, Ba2+, Al3+). For this reason, recently, a continuous and rising attention has been devoted to the ionic substitutions within the hydroxyapatite lattice in order to resemble the chemical composition of the bone mineral component and to improve its chemical, physical and mostly biological properties, for applications in biomedical sector, particularly in dentistry, orthopaedics and bone tissue engineering. The present manuscript provides a complete overview about the bi‐substituted hydroxyapatites in form of powders and coatings, in order to evidence the effect of the co‐doping with different vicarious ions within HAp lattice on its physicochemical properties, such as microstructure, morphology, thermal stability, solubility, thermal decomposition, dissolution, grain size, mechanical strength, degradation kinetics, corrosion resistance, and biological responsiveness, in terms of in vitro bioactivity, cytotoxicity and antibacterial action.

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“…Investigated compositions include

{CO}_{3}^{2 -}

/F − /Cl − /Na + /Mg 2+ /K + , Mg 2+ /Ni + /

{SiO}_{4}^{4 -}

, Sb 3+ /Mn 2+ /F − /Cl − , Sr 2+ /Mg 2+ /Mn 2+ , Mg 2+ /Zn 2+ /Co 2+ , Zn 2+ /Ag + /Au 2+ , Ag + /Zn 2+ /Mg 2+ /Sr 2+ , and

{CO}_{3}^{2 -}

/F − /Na + /Mg 2+ co‐substitutions.…”

Section: Multi‐substituted Hydroxyapatite Powders and Coatingsmentioning

confidence: 99%

“…Further multi‐substituted HAp coatings, mainly based on F − /

{CO}_{3}^{2 -}

Section: Multi‐substituted Hydroxyapatite Powders and Coatingsmentioning

confidence: 99%

Section: Multi‐substituted Hydroxyapatite Powders and Coatingsmentioning

confidence: 99%

“…Similarly, Hidalgo‐Robatto et al investigated the biological performances of multi‐substituted HAp coatings, mainly based on F − /

{CO}_{3}^{2 -}

Section: Multi‐substituted Hydroxyapatite Powders and Coatingsmentioning

confidence: 99%

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Multisubstituted hydroxyapatite powders and coatings: The influence of the codoping on the hydroxyapatite performances

Cacciotti

2019

Int J Applied Ceramic Tech

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“…Thickness of the PLD synthesized coatings can play an important role on their morphology, especially in the case of rough substrates. In Reference [89], films deposited in a water-vapor atmosphere onto Ti substrates were significantly thinner as compared to the ones deposited in vacuum. The calculated deposition rates were 3.5 nm/min for depositions conducted in water vapors, and 18.1 nm/min for depositions performed in vacuum.…”

Section: Morphological and Compositional Analysesmentioning

confidence: 99%

Current Status on Pulsed Laser Deposition of Coatings from Animal-Origin Calcium Phosphate Sources

Duta

Popescu

2019

Coatings

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The aim of this paper is to present the current status on animal-origin hydroxyapatite (HA) coatings synthesized by Pulsed Laser Deposition (PLD) technique for medical implant applications. PLD as a thin film synthesis method, although limited in terms of surface covered area, still gathers interest among researchers due to its advantages such as stoichiometric transfer, thickness control, film adherence, and relatively simple experimental set-up. While animal-origin HA synthesized by bacteria or extracted from animal bones, eggshells, and clams was tested in the form of thin films or scaffolds as a bioactive agent before, the reported results on PLD coatings from HA materials extracted from natural sources were not gathered and compared until the present study. Since natural apatite contains trace elements and new functional groups, such as CO32− and HPO42− in its complex molecules, physical-chemical results on the transfer of animal-origin HA by PLD are extremely interesting due to the stoichiometric transfer possibilities of this technique. The points of interest of this paper are the origin of HA from various sustainable resources, the extraction methods employed, the supplemental functional groups, and ions present in animal-origin HA targets and coatings as compared to synthetic HA, the coatings’ morphology function of the type of HA, and the structure and crystalline status after deposition (where properties were superior to synthetic HA), and the influence of various dopants on these properties. The most interesting studies published in the last decade in scientific literature were compared and morphological, elemental, structural, and mechanical data were compiled and interpreted. The biological response of different types of animal-origin apatites on a variety of cell types was qualitatively assessed by comparing MTS assay data of various studies, where the testing conditions were possible. Antibacterial and antifungal activity of some doped animal-origin HA coatings was also discussed.

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Sol–gel synthesis of calcium phosphate-based biomaterials—A review of environmentally benign, simple, and effective synthesis routes

Ishikawa

Kareiva

2020

J Sol-Gel Sci Technol

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In this review article the available results about application of sol-gel synthesis method for the preparation of different calcium phosphates and composite materials are summarized. The attention is paid to calcium phosphate-containing compounds which show the biological properties and could be used as potential phosphate bioceramics in medicine. It was demonstrated that the sol-gel synthesis method is a powerful tool for the synthesis of calcium hydroxyapatite and other phosphates, and different calcium phosphate-based composites at mild synthetic conditions resulted in high reproducibility, high phase purity, and desired morphology. Thus, the sol-gel synthesis method enables the researchers to develop biomaterials with superior features in terms of biomedical applications.

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Fluor‑carbonated hydroxyapatite coatings by pulsed laser deposition to promote cell viability and antibacterial properties

Cited by 25 publications

References 61 publications

Multisubstituted hydroxyapatite powders and coatings: The influence of the codoping on the hydroxyapatite performances

Multisubstituted hydroxyapatite powders and coatings: The influence of the codoping on the hydroxyapatite performances

Current Status on Pulsed Laser Deposition of Coatings from Animal-Origin Calcium Phosphate Sources

Sol–gel synthesis of calcium phosphate-based biomaterials—A review of environmentally benign, simple, and effective synthesis routes

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