F luidization is one of the most attractive processes in the chemical industry. Drying process in a fl uidized bed has various advantages, such as large contact area between particles and fl uid, high rates of heat and mass transfer as well as a very good level of solids mixing that facilitates temperature control.However, application of fl uidized bed drying has been abandoned in some fi elds, such as fi ne chemicals and the pharmaceutical industry, because of problems of thermal degradation and safety. The drying process, at relatively high temperatures or long residence times, may cause the partial degradation of thermolabile products. In addition, if the process is involved with evaporation of an organic solvent, as it is often the case in the pharmaceutical industry, a mixture within the fl ammability limits with a high risk of explosion can be formed. A reduced pressure operation in a fl uidized bed offers the possibility of eliminating these problems. Lower operating temperatures achieved under vacuum conditions reduce the probability of thermal degradation. Simultaneously, the lower pressure operation may provide a safer process out of fl ammability limits. Vacuum-fl uidized bed drying experiments were carried out with porous as well as compact particles, employing distinct operating pressures in two periods of drying, such that the combination of the effects of decrease in the transport capacity of the exterior medium and the enhancement of the internal diffusivity results in favour of the drying process. In a variety of operating conditions, it was observed that in the case of porous particles, increasing the operating pressure during the decreasing drying rate period, after applying a vacuum pressure in the constant drying rate period results in a lower fi nal particle humidity.Des expériences de séchage en lit fl uidisé sous vide ont été menées avec des particules poreuses et des particules compactes, avec des pressions opératoires distinctes pour deux périodes de séchage, de sorte que la combinaison des effets de la baisse de capacité de transport du milieu extérieur et l'amélioration de la diffusivité interne soient favorables au procédé de séchage. Dans diverses conditions opératoires, on a observé que dans le cas de particules poreuses, le fait d'accroître la pression opératoire lorsqu'on diminue la période de décroissance du taux de séchage, après avoir appliqué une pression à vide durant la période de taux de séchage constant entraîne une plus faible humidité fi nale des particules.