Fluidic flow delay by ionogel passive pumps in microfluidic paper-based analytical devices

Akyazi, Tuğçe; Sáez, Janire; Elizalde, J.; Benito‐Lopez, Fernando

doi:10.1016/j.snb.2016.04.116

Cited by 48 publications

(42 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, these techniques have a limited range of fluid control [6,31,34]. While there are many additional methods of passive fluid control in microPADs (e.g., fluidic diodes, delay shunts, altering pore size, ionogel passive pumps, laser direct writing, sucrose delays, chemical modifications, dissolvable/erodible bridges) [6,11,[36][37][38][39][40][41][42][43][44][45][46], all of these have significant limitations, such as the extensive use of additional fabrication materials or equipment beyond what is required for wax printing (e.g., laser cutters, plastic sheets, or adhesives) [39,40,44,45], use of reagents that could impact downstream assays (e.g., sugars, polymers, or surfactants) [11,38,42,43,46], or the use of techniques not compatible with high-volume fabrication [36,37,41].…”

Section: Introductionmentioning

confidence: 99%

Wax-Printed Fluidic Time Delays for Automating Multi-Step Assays in Paper-Based Microfluidic Devices (MicroPADs)

et al. 2019

View full text Add to dashboard Cite

Microfluidic paper-based analytical devices (microPADs) have emerged as a promising platform for point-of-care diagnostic devices. While the inherent wicking properties of microPADs allow for fluid flow without supporting equipment, this also presents a major challenge in achieving robust fluid control, which becomes especially important when performing complex multi-step assays. Herein, we describe an ideal method of fluid control mediated by wax-printed fluidic time delays. This method relies on a simple fabrication technique, does not utilize chemicals/reagents that could affect downstream assays, is readily scalable, and has a wide temporal range of tunable fluid control. The delays are wax printed on both the top and bottom of pre-fabricated microPAD channels, without subsequent heating, to create hemi-/fully-enclosed channels. With these wax printed delays, we were able to tune the time it took aqueous solutions to wick across a 25 mm-long channel between 3.6 min and 13.4 min. We then employed these fluid delays in the sequential delivery of four dyes to a test zone. Additionally, we demonstrated the automation of two simple enzymatic assays with this fluid control modality. This method of fluid control may allow future researchers to automate more complex assays, thereby further advancing microPADs toward real-world applications.

show abstract

Section: Introductionmentioning

confidence: 99%

Wax-Printed Fluidic Time Delays for Automating Multi-Step Assays in Paper-Based Microfluidic Devices (MicroPADs)

et al. 2019

View full text Add to dashboard Cite

show abstract

“…IOs are porous materials that swell in an aqueous environment. Upon absorbing large amounts of water, they change their volume abruptly which induces severe conformational changes in the microstructure, thus affecting their ion mobility . Therefore, our designed AZO‐IDEs have been used to monitor such changes by EIS.…”

Section: Resultsmentioning

confidence: 99%

“…Preparation of the Ionogel Solutions : The synthesis of the IOs was performed following the protocol described in reference . In brief a mixture of N ‐isopropylacrylamide (0.904 g), N,Nʹ ‐methylene‐bis(acrylamide) (0.025 g), 2,2‐dimethoxy‐2‐phenylacetophenone (0.021 g), and (2 mL) 1‐ethyl‐3‐methylimidazolium ethyl sulfate (IO‐1) or trihexyltetradecyl‐phosphonium dicyanamide (IO‐2) ionic liquid was placed in a flask and heated at 80 °C during 30 min.…”

Section: Methodsmentioning

confidence: 99%

AZO Embedded Interdigitated Electrodes for Monitoring Stimuli Responsive Materials

Gil-González

Chen

Akyazi

et al. 2018

Adv Funct Materials

Self Cite

View full text Add to dashboard Cite

A combination of atomic layer deposition and photolithography is applied to fabricate interdigitated electrodes of aluminum-doped zinc oxide embedded in polyethylene terephthalate substrates. Various designs with different gap to widths ratios are realized and important characteristics of the electrodes, including thickness, surface roughness, and electrical properties with different ZnO:Al 2 O 3 ratios are studied. Oxygen plasma is applied to etch the polyethylene terephthalate surface and to embed the electrodes, a methodology which is a breakthrough toward ultimately thin devices fabrication. Moreover, the influence of oxygen plasma on the electrical properties of aluminum-doped zinc oxide is analyzed in more detail. Electrochemical impedance spectroscopy studies of two different stimuli responsive ionogels are performed using the fabricated electrodes. The results show the suitability of the use of the fabricated electrodes to monitor changes in ion motion and morphology of stimuli responsive materials. These electrodes and the process of characterization of the ionogels presented could be implemented to monitor electrochemical changes in real applications such as protective coatings.

show abstract

“…for fluid control and transport in the devices. The increase of the cost of the devices resulted in the decrease of the market possibilities 35 . Therefore, "Lab on a paper" is being developed to provide an answer to deliver simple, cheap and autonomous devices which are easily manageable by the end-users 36 .…”

Section: Introductionmentioning

confidence: 99%

“…Paper is receiving a huge amount of attraction as a promising substrate material for microfluidic devices not only due to its extremely low cost and ubiquity but also due to its mechanical properties comprising flexibility, lightness, and low thickness 36 . In particular, µPADs is a relatively new group of analytical tools, capable of analysing complex biochemical samples, within one analytical run, where fluidic manipulations like transportation, sorting, mixing or separation are available 35, 38 . Thanks to the capillary forces of paper, there is no requirement for external pumps to provide fluid transport inside the paper unlike traditional microfluidic platforms 35 . However this advantage also generates a drawback; isotropic wicking behaviour of paper and the fluid transportation by any exposed surface area prevents the accurate control of the fluid transport on paper material, making it highly challenging and complicated 39,40 .…”

Section: Introductionmentioning

confidence: 99%

Manipulation of fluid flow direction in microfluidic paper-based analytical devices with an ionogel negative passive pump

Akyazi

Gil-González

Basabe‐Desmonts

et al. 2017

Sensors and Actuators B: Chemical

Self Cite

View full text Add to dashboard Cite

Microfluidic paper-based analytical devices (µPADs) are relatively new group of analytical tools that represent an innovative low-cost platform technology for fluid handling and analysis, enabling simple fabrication/operation and equipment independence and provide a wide range of applications. Nonetheless, µPADs lack in the effective handling and controlling of fluids, which leads to a main drawback for their reproducibility in large volumes during manufacturing, their transition from laboratory into the market and thus accessibility by the end-users. Herein we investigate the applicability of ionogel materials based on a poly(N-isopropylacrylamide) gel with the 1-ethyl-3methylimidazolium ethyl sulfate ionic liquid as fluid flow manipulator in µPADs using the ionogel as a negative passive pump to control the flow direction in the device. A big challenge undertook by this contribution is the integration of the ionogel materials into the µPADs. Finally, the characterisation and the performance of the ionogel as a negative passive pump were demonstrated.

show abstract

Fluidic flow delay by ionogel passive pumps in microfluidic paper-based analytical devices

Cited by 48 publications

References 26 publications

Wax-Printed Fluidic Time Delays for Automating Multi-Step Assays in Paper-Based Microfluidic Devices (MicroPADs)

Wax-Printed Fluidic Time Delays for Automating Multi-Step Assays in Paper-Based Microfluidic Devices (MicroPADs)

AZO Embedded Interdigitated Electrodes for Monitoring Stimuli Responsive Materials

Manipulation of fluid flow direction in microfluidic paper-based analytical devices with an ionogel negative passive pump

Contact Info

Product

Resources

About