Fluid–structure interaction within realistic three-dimensional models of the aneurysmatic aorta as a guidance to assess the risk of rupture of the aneurysm

Martino, Elena S. Di; Guadagni, Gualtiero; Fumero, Andrea; Ballerini, G; Spirito, Rita; Biglioli, Paolo; Redaelli, Alberto

doi:10.1016/s1350-4533(01)00093-5

Cited by 315 publications

(219 citation statements)

References 35 publications

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“…Numerical simulations with flexible walls have recently been presented by Masters et al 17,18 for idealized TCPC geometries, as well as for arterial problems. 3,8,11,26 However, relieving these assumptions in patient-specific geometries will require the development of fast and high-resolution solvers, which is where the commercial flow solver and mesh generation approaches used in this study may come into play.…”

Section: Limitations and Future Workmentioning

confidence: 99%

Progress in the CFD Modeling of Flow Instabilities in Anatomical Total Cavopulmonary Connections

et al. 2007

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Abstract-Intrinsic flow instability has recently been reported in the blood flow pathways of the surgically created total-cavopulmonary connection. Besides its contribution to the hydrodynamic power loss and hepatic blood mixing, this flow unsteadiness causes enormous challenges in its computational fluid dynamics (CFD) modeling. This paper investigates the applicability of hybrid unstructured meshing and solver options of a commercially available CFD package (FLUENT, ANSYS Inc., NH) to model such complex flows. Two patient-specific anatomies with radically different transient flow dynamics are studied both numerically and experimentally (via unsteady particle image velocimetry and flow visualization). A new unstructured hybrid mesh layout consisting of an internal core of hexahedral elements surrounded by transition layers of tetrahedral elements is employed to mesh the flow domain. The numerical simulations are carried out using the parallelized second-order accurate upwind scheme of FLUENT. The numerical validation is conducted in two stages: first, by comparing the overall flow structures and velocity magnitudes of the numerical and experimental flow fields, and then by comparing the spectral content at different points in the connection. The numerical approach showed good quantitative agreement with experiment, and total simulation time was well within a clinically relevant time-scale of our surgical planning application. It also further establishes the ability to conduct accurate numerical simulations using hybrid unstructured meshes, a format that is attractive if one ever wants to pursue automated flow analysis in a large number of complex (patient-specific) geometries.

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Section: Limitations and Future Workmentioning

confidence: 99%

Progress in the CFD Modeling of Flow Instabilities in Anatomical Total Cavopulmonary Connections

et al. 2007

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“…The AAA arises in the infrarenal aorta with a diameter greater than 3 cm and can be up to 9 cm in length [1,2]. Most of the studies on aneurysms have focused on already existing realistic or idealized aneurysms [33][34][35][36][37][38][39][40][41][42][43] with the aim of defining a relevant rupture criterion [4,7,10,19,20,24]. The ratio of the vessel stress to vessel strength is regarded as an alternative tool to conventional diameter criteria, which may be insufficient in small aneurysms.…”

mentioning

confidence: 99%

Investigation of material modeling in fluid–structure interaction analysis of an idealized three-layered abdominal aorta: aneurysm initiation and fully developed aneurysms

Şimşek

Kwon

2015

J Biol Phys

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Different material models for an idealized three-layered abdominal aorta are compared using computational techniques to study aneurysm initiation and fully developed aneurysms. The computational model includes fluid-structure interaction (FSI) between the blood vessel and the blood. In order to model aneurysm initiation, the medial region was degenerated to mimic the medial loss occurring in the inception of an aneurysm. Various cases are considered in order to understand their effects on the initiation of an abdominal aortic aneurysm. The layers of the blood vessel were modeled using either linear elastic materials or Mooney-Rivlin (otherwise known as hyperelastic) type materials. The degenerated medial region was also modeled in either linear elastic or hyperelastic-type materials and assumed to be in the shape of an arc with a thin width or a circular ring with different widths. The blood viscosity effect was also considered in the initiation mechanism. In addition, dynamic analysis of the blood vessel was performed without interaction with the blood flow by applying time-dependent pressure inside the lumen in a three-layered abdominal aorta. The stresses, strains, and displacements were compared for a healthy aorta, an initiated aneurysm and a fully developed aneurysm. The study shows that the material modeling of the vessel has a sizable effect on aneurysm initiation and fully developed aneurysms. Different material modeling of degeneration regions also affects the stressstrain response of aneurysm initiation. Additionally, the structural analysis without considering FSI (called noFSI) overestimates the peak von Mises stress by 52% at the interfaces of the layers.

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“…Realistic representation of blood flow can be obtained by solving the fundamental equations of the flow with realistic vessel geometries obtained by medical imaging techniques such as magnetic resonance imaging (MRI) or computed tomography (CT). 3,4,8,12,15,16,24,26,30 Numerical simulation dealing with flow in an aorta with an aneurysm has also been carried out by such a combination. 3,4,26 Taylor and Yamaguchi reported the appearance and disappearance of a primary vortex and regions of high shear stresses both at the proximal and distal ends of the aneurysm.…”

Section: Introductionmentioning

confidence: 99%

“…3,4,8,12,15,16,24,26,30 Numerical simulation dealing with flow in an aorta with an aneurysm has also been carried out by such a combination. 3,4,26 Taylor and Yamaguchi reported the appearance and disappearance of a primary vortex and regions of high shear stresses both at the proximal and distal ends of the aneurysm. 26 Di Martino et al studied the complex mechanical interaction between blood flow and wall dynamics in a three-dimensional custom model of an abdominal aortic aneurysm and provided a quantitative local evaluation of the stresses.…”

Section: Introductionmentioning

confidence: 99%

“…26 Di Martino et al studied the complex mechanical interaction between blood flow and wall dynamics in a three-dimensional custom model of an abdominal aortic aneurysm and provided a quantitative local evaluation of the stresses. 3 However, numerical simulation has an inherent problem of specification of the boundary conditions, 8,12,15,16 and thus the calculated blood flow is usually similar but not identical to the real one. In order to minimize the effect of inaccurate inlet velocity profile specification on local wall shear stress computations in the vessel segment, Liu et al extended their model of the carotid artery in the upstream direction with a straight tube, proposing that such extension may be useful until more accurate, noninvasively obtained velocity profile data for the inlet become available.…”

Section: Introductionmentioning

confidence: 99%

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Fundamental Study of Ultrasonic-Measurement-Integrated Simulation of Real Blood Flow in the Aorta

et al. 2005

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Abstract-Acquisition of detailed information on the velocity and pressure fields of the blood flow is essential to achieve accurate diagnosis or treatment for serious circulatory diseases such as aortic aneurysms. A possible way to obtain such information is integration of numerical simulation and color Doppler ultrasonography in the framework of a flow observer. This methodology, namely, Ultrasonic-Measurement-Integrated (UMI) Simulation, consists of the following processes. At each time step of numerical simulation, the difference between the measurable output signal and the signal indicated by numerical simulation is evaluated. Feedback signals are generated from the difference, and numerical simulation is updated applying the feedback signal to compensate for the difference. This paper deals with a numerical study on the fundamental characteristics of UMI simulation using a simple two-dimensional model problem for the blood flow in an aorta with an aneurysm. The effect of the number of feedback points and the feedback formula are investigated systematically. It is revealed that the result of UMI simulation in the feedback domain rapidly converges to the standard solution, even with usually inevitable incorrect upstream boundary conditions. Finally, an example of UMI simulation with feedback from real color Doppler measurement also shows a good agreement with measurement.

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Fluid–structure interaction within realistic three-dimensional models of the aneurysmatic aorta as a guidance to assess the risk of rupture of the aneurysm

Cited by 315 publications

References 35 publications

Progress in the CFD Modeling of Flow Instabilities in Anatomical Total Cavopulmonary Connections

Progress in the CFD Modeling of Flow Instabilities in Anatomical Total Cavopulmonary Connections

Investigation of material modeling in fluid–structure interaction analysis of an idealized three-layered abdominal aorta: aneurysm initiation and fully developed aneurysms

Fundamental Study of Ultrasonic-Measurement-Integrated Simulation of Real Blood Flow in the Aorta

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