Fluid-Structure Interaction Model of Human Mitral Valve within Left Ventricle

Gao, Hao; Qi, Nan; Ma, Xingshuang; Griffith, Boyce E.; Berry, Colin; Luo, Xiaoyu

doi:10.1007/978-3-319-20309-6_38

Cited by 3 publications

(9 citation statements)

References 17 publications

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“…Even in the FSI models, the MV and its sub‐apparatus are usually mounted into a tube‐like or ventricular‐like shapes, with pressure or flow waveforms applied at the inflow and outflow tracts . More sophisticated boundary conditions have also been introduced to account for the ventricular dynamics, using either a prescribed motion or a coupled MV‐ventricular model …”

Section: Coupled Mv‐lv Modelling (With/without Fsi)mentioning

confidence: 99%

“…Streamlines in an integrated MV‐LV model at (A) early diastolic filling, (B) late diastolic filling, (C) when the MV is closing, and (D) middle of the systolic ejection. Coloured by the velocity magnitude.…”

Section: Coupled Mv‐lv Modelling (With/without Fsi)mentioning

confidence: 99%

“…The interaction between heart valves and the heart chambers requires modelling of the blood flow, preferably in a 4‐chamber heart. To date, very few studies focused on physiologically realistic valvular‐heart models, even fewer reported valve‐heart modelling with FSI . This is primarily due to the limitations of clinical imaging, lack of computational power, and complexity in multi‐physics modelling.…”

Section: Challenges and Future Directionsmentioning

confidence: 99%

“…18,26,32,59,60,103,115,146 More sophisticated boundary conditions have also been introduced to account for the ventricular dynamics, using either a prescribed motion 89 or a coupled MV-ventricular model. 104,155 Despite the strong coupling between the MV and LV, few modelling studies have integrated the MV and LV simultaneously into a single model, 104,156,157 particularly with FSI. 144 This is because integrated MV-LV approach faces a number of challenges:…”

Section: Coupled Mv-lv Modelling (With/without Fsi)mentioning

confidence: 99%

“…An integrated MV-LV model with FSI has been developed by the authors' group. 155 This was the first 3D FSI MV-LV model that was based on MR images and included the LV contraction, nonlinear soft tissue mechanics, and FSI within the IB/FE framework. The instantaneous streamlines of this model in Figure 2 show how flow patterns are strongly affected by the LV deformation.…”

Section: Coupled Mv-lv Modelling (With/without Fsi)mentioning

confidence: 99%

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Modelling mitral valvular dynamics–current trend and future directions

Gao

Feng

et al. 2017

Numer Methods Biomed Eng

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Dysfunction of mitral valve causes morbidity and premature mortality and remains a leading medical problem worldwide. Computational modelling aims to understand the biomechanics of human mitral valve and could lead to the development of new treatment, prevention and diagnosis of mitral valve diseases. Compared with the aortic valve, the mitral valve has been much less studied owing to its highly complex structure and strong interaction with the blood flow and the ventricles. However, the interest in mitral valve modelling is growing, and the sophistication level is increasing with the advanced development of computational technology and imaging tools. This review summarises the state‐of‐the‐art modelling of the mitral valve, including static and dynamics models, models with fluid‐structure interaction, and models with the left ventricle interaction. Challenges and future directions are also discussed.

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Section: Coupled Mv‐lv Modelling (With/without Fsi)mentioning

confidence: 99%

Section: Coupled Mv‐lv Modelling (With/without Fsi)mentioning

confidence: 99%

Section: Challenges and Future Directionsmentioning

confidence: 99%

Section: Coupled Mv-lv Modelling (With/without Fsi)mentioning

confidence: 99%

Section: Coupled Mv-lv Modelling (With/without Fsi)mentioning

confidence: 99%

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Modelling mitral valvular dynamics–current trend and future directions

Gao

Feng

et al. 2017

Numer Methods Biomed Eng

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An Image-Based Computational Fluid Dynamics Study of Mitral Regurgitation in Presence of Prolapse

Bennati

Vergara

Giambruno

et al. 2023

Cardiovasc Eng Tech

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Purpose In this work we performed an imaged-based computational study of the systolic fluid dynamics in presence of mitral valve regurgitation (MVR). In particular, we compared healthy and different regurgitant scenarios with the aim of quantifying different hemodynamic quantities. Methods We performed computational fluid dynamic (CFD) simulations in the left ventricle, left atrium and aortic root, with a resistive immersed method, a turbulence model, and with imposed systolic wall motion reconstructed from Cine-MRI images, which allowed us to segment also the mitral valve. For the regurgitant scenarios we considered an increase of the heart rate and a dilation of the left ventricle. Results Our results highlighted that MVR gave rise to regurgitant jets through the mitral orifice impinging against the atrial walls and scratching against the mitral valve leading to high values of wall shear stresses (WSSs) with respect to the healthy case. Conclusion CFD with prescribed wall motion and immersed mitral valve revealed to be an effective tool to quantitatively describe hemodynamics in case of MVR and to compare different regurgitant scenarios. Our findings highlighted in particular the presence of transition to turbulence in the atrium and allowed us to quantify some important cardiac indices such as cardiac output and WSS.

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A workflow for patient-specific fluid–structure interaction analysis of the mitral valve: A proof of concept on a mitral regurgitation case

Biffi

Gritti

Grasso

et al. 2019

Medical Engineering & Physics

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The mechanics of the mitral valve (MV) are the result of the interaction of different anatomical structures complexly arranged within the left heart (LH), with the blood flow. MV structure abnormalities might cause valve regurgitation which in turn can lead to heart failure. Patient-specific computational models of the MV could provide a personalised understanding of MV mechanics, dysfunctions and possible interventions. In this study, we propose a semi-automatic pipeline for MV modelling based on the integration of state-of-the-art medical imaging, i.e. cardiac magnetic resonance (CMR) and 3D transoesophagealechocardiogram (TOE) with fluid-structure interaction (FSI) simulations. An FSI model of a patient with MV regurgitation was implemented using the finite element (FE) method and smoothed particle hydrodynamics (SPH). Our study showed the feasibility of combining image information and computer simulations to reproduce patient-specific MV mechanics as seen on medical images, and the potential for efficient in-silico studies of MV disease, personalised treatments and device design.

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Fluid-Structure Interaction Model of Human Mitral Valve within Left Ventricle

Cited by 3 publications

References 17 publications

Modelling mitral valvular dynamics–current trend and future directions

Modelling mitral valvular dynamics–current trend and future directions

An Image-Based Computational Fluid Dynamics Study of Mitral Regurgitation in Presence of Prolapse

A workflow for patient-specific fluid–structure interaction analysis of the mitral valve: A proof of concept on a mitral regurgitation case

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