Fluid-structure interaction in layered aortic arch aneurysm model: assessing the combined influence of arch aneurysm and wall stiffness

Gao, Feng; Ohta, Osamu; Matsuzawa, Teruo

doi:10.1007/bf03178451

Cited by 20 publications

(17 citation statements)

References 42 publications

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“…Figure 16 shows that, in both the intact and aneurismal vessel, the von Mises stress is highest in the media and lowest in the intima. These results are validated by previous investigations by Khanafer et al, who studied aortic dissection in a layered idealized descending aorta model, and by Gao et al, who studied an aneurysm in an idealized layered aortic arch model [43,59]. Although the magnitudes of the stress are not the same due to differences in types of vessels, the von Mises stress distribution through layers was consistent with the present study.…”

Section: Blood Viscosity Effectsupporting

confidence: 93%

“…Another finding shown in Fig. 17 was that maximum stress in the aneurismal aorta occurred at the inflection regions as shown in Gao's study [43].…”

Section: Blood Viscosity Effectmentioning

confidence: 58%

“…The AAA arises in the infrarenal aorta with a diameter greater than 3 cm and can be up to 9 cm in length [1,2]. Most of the studies on aneurysms have focused on already existing realistic or idealized aneurysms [33][34][35][36][37][38][39][40][41][42][43] with the aim of defining a relevant rupture criterion [4,7,10,19,20,24]. The ratio of the vessel stress to vessel strength is regarded as an alternative tool to conventional diameter criteria, which may be insufficient in small aneurysms.…”

mentioning

confidence: 99%

“…Since imaging techniques are not sufficiently reliable to obtain the accurate vessel thickness, vessel thickness was assumed to be uniform, having the same material properties through the vessel. However, in vivo studies have shown that each layer differs in its contribution to the material properties of the vessel [43,[55][56][57][58][59][60]. Gao et al conducted stress analysis in a layered aortic arch aneurysm [43] and in a recent study they compared stenting and wrapping techniques in a 2D-layered idealized abdominal aortic aneurysm [40].…”

mentioning

confidence: 99%

“…However, in vivo studies have shown that each layer differs in its contribution to the material properties of the vessel [43,[55][56][57][58][59][60]. Gao et al conducted stress analysis in a layered aortic arch aneurysm [43] and in a recent study they compared stenting and wrapping techniques in a 2D-layered idealized abdominal aortic aneurysm [40]. Khanafer et al also studied aortic dissection in a layered aortic arch by utilizing physiological waveforms at the inlet and outlet of an aorta [59].…”

mentioning

confidence: 99%

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Investigation of material modeling in fluid–structure interaction analysis of an idealized three-layered abdominal aorta: aneurysm initiation and fully developed aneurysms

Şimşek

Kwon

2015

J Biol Phys

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Different material models for an idealized three-layered abdominal aorta are compared using computational techniques to study aneurysm initiation and fully developed aneurysms. The computational model includes fluid-structure interaction (FSI) between the blood vessel and the blood. In order to model aneurysm initiation, the medial region was degenerated to mimic the medial loss occurring in the inception of an aneurysm. Various cases are considered in order to understand their effects on the initiation of an abdominal aortic aneurysm. The layers of the blood vessel were modeled using either linear elastic materials or Mooney-Rivlin (otherwise known as hyperelastic) type materials. The degenerated medial region was also modeled in either linear elastic or hyperelastic-type materials and assumed to be in the shape of an arc with a thin width or a circular ring with different widths. The blood viscosity effect was also considered in the initiation mechanism. In addition, dynamic analysis of the blood vessel was performed without interaction with the blood flow by applying time-dependent pressure inside the lumen in a three-layered abdominal aorta. The stresses, strains, and displacements were compared for a healthy aorta, an initiated aneurysm and a fully developed aneurysm. The study shows that the material modeling of the vessel has a sizable effect on aneurysm initiation and fully developed aneurysms. Different material modeling of degeneration regions also affects the stressstrain response of aneurysm initiation. Additionally, the structural analysis without considering FSI (called noFSI) overestimates the peak von Mises stress by 52% at the interfaces of the layers.

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Section: Blood Viscosity Effectsupporting

confidence: 93%

“…Another finding shown in Fig. 17 was that maximum stress in the aneurismal aorta occurred at the inflection regions as shown in Gao's study [43].…”

Section: Blood Viscosity Effectmentioning

confidence: 58%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Investigation of material modeling in fluid–structure interaction analysis of an idealized three-layered abdominal aorta: aneurysm initiation and fully developed aneurysms

Şimşek

Kwon

2015

J Biol Phys

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Impact of shear stress and atherosclerosis on entrance-tear formation in patients with acute aortic syndromes

et al. 2013

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Weak aortic media layers can lead to intimal tear (IT) in patients with overt aortic dissection (AD), and aortic plaque rupture is thought to progress to penetrating atherosclerotic ulcer (PAU) with intramural hematoma (IMH). However, the influences of shear stress and atherosclerosis on IT and PAU have not been fully examined. Ninety-eight patients with overt AD and 30 patients with IMH and PAU admitted to our hospital from 2002 to 2007 were enrolled. The greater curvatures of the aorta, including the anterior and right portions of the ascending aorta and anterior portion of the aortic arch, were defined as sites of high shear stress. The other portions of the aorta were defined as sites of low shear stress based on anatomic and hydrodynamic theories. Aortic calcified points (ACPs) were manually counted on computed tomography slices of the whole aorta every 10 mm from the top of the arch to the abdominal bifurcation point. IT was more often observed at sites of high shear stress in overt AD than in PAU (73.5 vs 20.0 %, P < 0.0001). Significantly more ACPs were present in PAU than in overt AD (18.6 ± 8 vs 13.3 ± 10, P = 0.007). The present study suggests that high shear stress and less severe atherosclerosis could induce the occurrence of an IT, thereafter progressing to overt AD, and that low shear stress and more severe atherosclerosis could proceed to PAU with IMH. These findings may help to identify the entrance-tear site.

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Assessing abdominal aorta narrowing using computational fluid dynamics

AL-Rawi

Al‐Jumaily

2015

Med Biol Eng Comput

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This paper investigates the effect of developing arterial blockage at the abdominal aorta on the blood pressure waves at an externally accessible location suitable for invasive measurements such as the brachial and the femoral arteries. Arterial blockages are created surgically within the abdominal aorta of healthy Wistar rats to create narrowing resemblance conditions. Blood pressure is measured using a catheter inserted into the right femoral artery. Measurements are taken at the baseline healthy condition as well as at four different severities (20, 50, 80 and 100 %) of arterial blockage. In vivo and in vitro measurements of the lumen diameter and wall thickness are taken using magnetic resonance imaging and microscopic techniques, respectively. These data are used to validate a 3D computational fluid dynamics model which is developed to generalize the outcomes of this work and to determine the arterial stress and strain under the blockage conditions. This work indicates that an arterial blockage in excess of 20 % of the lumen diameter significantly influences the pressure wave and reduces the systolic blood pressure at the right femoral artery. High wall shear stresses and low circumferential strains are also generated at the blockage site.

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Fluid-structure interaction in layered aortic arch aneurysm model: assessing the combined influence of arch aneurysm and wall stiffness

Cited by 20 publications

References 42 publications

Investigation of material modeling in fluid–structure interaction analysis of an idealized three-layered abdominal aorta: aneurysm initiation and fully developed aneurysms

Investigation of material modeling in fluid–structure interaction analysis of an idealized three-layered abdominal aorta: aneurysm initiation and fully developed aneurysms

Impact of shear stress and atherosclerosis on entrance-tear formation in patients with acute aortic syndromes

Assessing abdominal aorta narrowing using computational fluid dynamics

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