Fluid-structure interaction analysis on the effects of vessel material properties on blood flow characteristics in stenosed arteries under axial rotation

Abstract

We conducted blood flow analysis, using the Fluid-Structure Interaction (FSI) method, to examine how changes in the material properties of blood vessels affect blood flow characteristics, using the carotid artery as the model vessel. The geometry of the blood vessel included 50% stenosis at the center, and blood was modeled as a non-Newtonian fluid. In order to investigate the effects of vessel material properties, linear elastic models with 0.21 MPa, 0.51 MPa, and 1.25 MPa, which are within the typical elastic modulus range of the carotid artery, were used to simulate the blood vessel, and these were compared with the rigid body model. The difference in blood vessel elasticity caused periodic and transient changes in blood flow. The more elastic the blood vessel becomes, the longer the periods of velocity, pressure, and Wall Shear Stress (WSS) change and the smaller the size of the Fluid Recirculation Zone (FRZ). Also, transient changes in blood flow occurred due to the accumulation of differences in flow caused by vessel wall deformation. This is because a change in the stiffness of the vessel wall causes the vessel's vibration period to change, leading to changes in blood flow.

Computational analysis of the effectiveness of blood flushing with saline injection from an intravascular diagnostic catheter

“…It appears from the fluid‐structure interaction study by Cho et al that WSS can be more than 20% higher for deformable vessels, as compared with rigid vessel walls. It would be therefore useful to extend the present study to consider deformable vessels, with a more quantitatively accurate arterial input function for the pulsatile blood flow rate (e.g., as in ).…”

“…Cho et al performed a numerical study of the effects of blood vessel properties on blood flow characteristics in stenosed arteries using fluid‐structure interaction. Their studies show that the rigid vessel assumption underpredicts WSS by about 20%.…”

Numerical investigation of hyperelastic wall deformation characteristics in a micro-scale stenotic blood vessel

“…This result shows the significant effect of the presence of stenosis in a micro-channel on wall deformation. The results further indicate that an increase in stenosis severity results in greater arteriole wall deformation with high pressure gradients, which can be used as a significant indicator of hypertension (Kawasaki et al, 2009;Cho et al, 2011).…”

Modeling thrombus formation and growth

“…In arterial thrombosis, two factors at the wall boundary determine the extent of thrombus growth: geometry (or stenosis degree), and surface material properties of the thrombus (Cho et al, 2011). and wall shear rate in stenosed (75% area reduction) collagen-coated tube.…”