Fluid resuscitation in acute pancreatitis: Normal saline or lactated Ringer's solution?

Abstract

Our study failed to find any evidence that the administration of RL in the first days of AP leads to improved clinical outcomes.

Ringer's lactate versus normal saline in acute pancreatitis: A systematic review and meta‐analysis

“…Most of these 19 studies were reports of a comparison between Ringer's lactate with normal saline in post‐ERCP pancreatitis. Finally, five studies including 428 participants met the eligibility criteria. Two of the included studies were retrospective observational cohort studies and three were RCTs.…”

“…hydration in these patients . Recent studies have shown that use of a more balanced solution, Ringer's lactate, can improve mortality rates and decrease the development of SIRS over 24–48 h in these patients, compared with normal saline . However, existing data are conflicting and are limited to small‐sized studies.…”

EPC/HPSG evidence-based guidelines for the management of pediatric pancreatitis

“…Aggressive intravenous hydration with lactated Ringer's solution appears to reduce the development of post-ERCP pancreatitis and is not associated with volume overload 72 . Other studies show no added benefit from lactated Ringer's solution compared to normal saline in terms of mortality and the duration of hospital stay 73 .…”

Systematic review: periprocedural hydration in the prevention of post‐ERCP pancreatitis

“…Guidelines on acute pancreatitis advocate the use of lactated Ringer's solution based on one well‐designed study that was terminated after an interim analysis of 40 patients . This is at odds with a recent retrospective study that did not find a significant difference between lactated Ringer's solution and normal saline in terms of disease severity, pancreatic necrosis and mortality . The included studies offer no clear guidance on this issue.…”