Fluctuations and stirring rate effects in the chlorite-thiosulfate reaction

Nagypál, Ištván; Epstein, Irving R.

doi:10.1021/j100281a044

Cited by 156 publications

(168 citation statements)

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“…The Chlorite-Tetrathionate (C-T) reaction has essentially been studied in closed systems for the determination of stoichiometric and kinetic aspects [23,24] as well as a source for propagating cellular fronts [12,13,14]. In excess of chlorite, the reaction kinetics is well approximated by the following overall balance equation…”

Section: B the Chlorite-tetrathionate Reactionmentioning

confidence: 99%

Dynamical effects induced by long range activation in a nonequilibrium reaction-diffusion system

et al. 2002

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We show both experimentally and numerically that the time scales separation introduced by long range activation can induce oscillations and excitability in nonequilibrium reaction-diffusion systems that would otherwise only exhibit bistability. Namely, we show that in the ChloriteTetrathionate reaction, where the autocalytic species H + diffuses faster than the substrates, the spatial bistability domain in the nonequilibrium phase diagram is extended with oscillatory and excitability domains. A simple model and a more realistic model qualitatively account for the observed dynamical behavior. The latter model provides quantitative agreement with the experiments.

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Section: B the Chlorite-tetrathionate Reactionmentioning

confidence: 99%

Dynamical effects induced by long range activation in a nonequilibrium reaction-diffusion system

et al. 2002

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“…We showed that combining a simple chemical mechanism 9,10,13 can be used to make testable predictions about the spatiotemporal dynamics of the network. We experimentally confirmed these predictions using microfluidics.…”

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confidence: 99%

Propagation of Blood Clotting in the Complex Biochemical Network of Hemostasis Is Described by a Simple Mechanism

et al. 2007

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Hemostasis is the complex biochemical network that controls blood clotting. We previously described a chemical model that mimicked the dynamics of hemostasis based on a simple regulatory mechanisma threshold response due to the competition between production and removal of activators. Here, we used human blood plasma in phospholipid-coated microfluidic channels to test predictions based on this mechanism. We demonstrated that, for a given geometry of channels, clot propagation from an obstructed channel into a channel with flowing blood plasma is dependent on the shear rate in the channel with flowing blood plasma. If confirmed in vivo, these results may explain clot propagation from a small vessel to a larger, clinically relevant vessel. In addition, these results would further validate the use of modular mechanisms, simplified chemical models, and microfluidics to study complex biochemical networks.

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“…This is important because the stochastic aspects must be observed in the kinetics of these processes as well. However, experimental examples of detectable stochastic kinetic effects in autocatalytic reactions not involving any chiral material were provided by the pioneering work of Nagypál and Epstein [20][21]. The first such process studied was the reaction between chlorite ion and thiosulfate ion, the stoichiometry of which can be described by the combination of the following two reactions depending on the experimental conditions [20]:…”

Section: Stochastic Experimental Observations Relevant For Chirality mentioning

confidence: 99%

“…Statistical reaction time distributions (D: distribution function) measured in the chlorite ion-thiosulfate ion (N1) [20] and chlorite ion-iodide ion (N2) [21] reaction.…”

Section: Stochastic Experimental Observations Relevant For Chirality mentioning

confidence: 99%

The Role of Stochastic Models in Interpreting the Origins of Biological Chirality

Lente

2010

Symmetry

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This review summarizes recent stochastic modeling efforts in the theoretical research aimed at interpreting the origins of biological chirality. Stochastic kinetic models, especially those based on the continuous time discrete state approach, have great potential in modeling absolute asymmetric reactions, experimental examples of which have been reported in the past decade. An overview of the relevant mathematical background is given and several examples are presented to show how the significant numerical problems characteristic of the use of stochastic models can be overcome by non-trivial, but elementary algebra. In these stochastic models, a particulate view of matter is used rather than the concentration-based view of traditional chemical kinetics using continuous functions to describe the properties system. This has the advantage of giving adequate description of single-molecule events, which were probably important in the origin of biological chirality. The presented models can interpret and predict the random distribution of enantiomeric excess among repetitive experiments, which is the most striking feature of absolute asymmetric reactions. It is argued that the use of the stochastic kinetic approach should be much more widespread in the relevant literature.

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Fluctuations and stirring rate effects in the chlorite-thiosulfate reaction

Cited by 156 publications

References 0 publications

Dynamical effects induced by long range activation in a nonequilibrium reaction-diffusion system

Dynamical effects induced by long range activation in a nonequilibrium reaction-diffusion system

Propagation of Blood Clotting in the Complex Biochemical Network of Hemostasis Is Described by a Simple Mechanism

The Role of Stochastic Models in Interpreting the Origins of Biological Chirality

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