Fluctuation of treatment need for temporomandibular disorders and age, gender, stress, and diagnostic subgroup

Kuttila, M; Kuttila, Seppo; Pm, Niemi; Alanen, Pentti; Y, Le Bell

doi:10.3109/00016359709059199

Cited by 60 publications

(72 citation statements)

References 10 publications

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“…Temporomandibular disorder (TMD) is characterized by a triad of symptoms, including joint sounds, pain, and limited mandibular movement (Kuttila et al, 1998). These symptomatic variants indicate that TMD is caused by a combination of factors, such as occlusion, mental stress, strength, endurance, and hormones; however, the etiology of this disease is not fully understood.…”

mentioning

confidence: 99%

Expression of estrogen receptor α (ERα) in the rat temporomandibular joint

Yamada¹,

Nozawa-Inoue²,

Kawano³

et al. 2003

Anat. Rec.

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Numerous epidemiological studies have pointed out a higher frequency of temporomandibular disorder (TMD) in women than in men, which indicates the involvement of a sex hormone, such as estrogen, in the pathogenesis of TMD. Although estrogen is known to play pivotal roles in osteoarthrosis or rheumatoid arthritis in systemic joints, there have been few reports about the role of estrogen in the temporomandibular joint (TMJ). The effect of estrogen is generally mediated by the estrogen receptors (ERs) ER␣ (the predominant type) and ER␤. In this study we examined the expression of ER␣ protein and mRNA in the TMJ of adult male rats by immunocytochemistry and in situ hybridization histochemistry. Intense ER␣ immunoreactivity was localized in the synovial lining cells, stromal cells in the articular disc, and chondrocytes in the TMJ. These ER␣-immunopositive synovial lining cells are characteristic of cytoplasmic processes identified with confocal and immunoelectron microscopy, which indicates that they are synovial type B cells. In situ hybridization histochemistry confirmed intense signals for ER␣ in the synovial lining cells and the sublining fibroblasts at mRNA levels. The nuclei of chondrocytes showed an intense immunoreaction for ER␣ in the maturative and hypertrophic layers of the articular cartilage. In addition to the nuclear localization of ER␣, a weak immunoreaction appeared in the cytoplasm of some ER␣-positive cells. These findings support the hypothesis that TMJ tissue-at least in the male rat-has the potential to be an estrogen target tissue. Anat Rec Part A 274A: 934 -941, 2003.

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mentioning

confidence: 99%

Expression of estrogen receptor α (ERα) in the rat temporomandibular joint

Yamada¹,

Nozawa-Inoue²,

Kawano³

et al. 2003

Anat. Rec.

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“…Temporomandibular disorder (TMD) is a common clinical entity [1,2]. The prevalence of TMD in the adult population ranges from 25 to 50 per cent [3].…”

Section: Introductionmentioning

confidence: 99%

A digital process for additive manufacturing of occlusal splints: a clinical pilot study

Salmi

Paloheimo

Tuomi

et al. 2013

J. R. Soc. Interface.

101

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The aim of this study was to develop and evaluate a digital process for manufacturing of occlusal splints. An alginate impression was taken from the upper and lower jaws of a patient with temporomandibular disorder owing to cross bite and wear of the teeth, and then digitized using a table laser scanner. The scanned model was repaired using the 3DATA EXPERT software, and a splint was designed with the VISCAM RP software. A splint was manufactured from a biocompatible liquid photopolymer by stereolithography. The system employed in the process was SLA 350. The splint was worn nightly for six months. The patient adapted to the splint well and found it comfortable to use. The splint relieved tension in the patient's bite muscles. No sign of tooth wear or significant splint wear was detected after six months of testing. Modern digital technology enables us to manufacture clinically functional occlusal splints, which might reduce costs, dental technician working time and chair-side time. Maximum-dimensional errors of approximately 1 mm were found at thin walls and sharp corners of the splint when compared with the digital model.

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“…Temporomandibular disorder (TMD) is characterized by a triad of symptoms, including joint sounds, pain, and limited mandibular movement (4). These symptomatic variants indicate that TMD is caused by a combination of factors, such as occlusion, mental stress, strength, and hormones; however, the etiology of this disease is not fully understood.…”

Section: Introductionmentioning

confidence: 99%

Effect of estrogen on bone resorption and inflammation in the temporomandibular joint cellular elements

Galal

Beialy²,

Deyama³

et al. 2008

Int J Mol Med

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Abstract. Several epidemiological studies have reported that temporomandibular disorder is more prevalent in women, which suggests the involvement of sex hormones, such as estrogen, in the pathogenesis of this disease. PCR amplification and Western blotting were employed to target the expression of estrogen receptors (ERs) in human fibroblast-like synovial and ATDC5 cells. The effect of estrogen was investigated through the expression of RANKL, osteoprotegerin (OPG), M-CSF/CSF-1 and c-fms. We showed expression of M-CSF/ CSF-1 and c-fms, with time-dependent increase in both after the addition of estrogen. Based on previous studies reporting that M-CSF/CSF-1 regulates the proliferation and differentiation of hemopoietic progenitor cells into mature macrophages, we put forward a new hypothesis based on the increased inflammation and tendency of females to suffer more from temporomandibular disorder (TMD) in the presence of external exacerbating factors. Detection of RANKL and OPG in ATDC5 and expression of both in HFLS was confirmed with complete disappearance of the RANKL band, and marked increase in the expression of OPG after 1 h from the addition of estrogen.

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Fluctuation of treatment need for temporomandibular disorders and age, gender, stress, and diagnostic subgroup

Cited by 60 publications

References 10 publications

Expression of estrogen receptor α (ERα) in the rat temporomandibular joint

Expression of estrogen receptor α (ERα) in the rat temporomandibular joint

A digital process for additive manufacturing of occlusal splints: a clinical pilot study

Effect of estrogen on bone resorption and inflammation in the temporomandibular joint cellular elements

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