Flubendiamide, a Novel Insecticide Highly Active against Lepidopterous Insect Pests

Abstract

Flubendiamide, N2 -[1,1-dimethyl-2-(methylsulfonyl)ethyl]-3-iodo-N 1 -[2-methyl-4-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]phenyl]-1,2-benzenedicarboxamide, is a novel class of insecticide having a unique chemical structure. The uniqueness of the structure results from three parts with novel substituents; a heptafluoroisopropyl group in the anilide moiety, a sulfonylalkyl group in the aliphatic amide moiety, and an iodine atom at the 3-position of the phthalic acid moiety. The compound shows extremely strong insecticidal activity especially against lepidopterous pests including resistant strains. Flubendiamide would have a novel mode of action, because the insecticidal symptoms accompanied by a discriminative contraction of the larval body are distinguished from those of commercial insecticides. It is also very safe for non-target organisms. Flubendiamide is expected to be a suitable agent for controlling lepidopterous insects as part of the insect resistance management and the integrated pest management programs.

Seasonal proportion change of ryanodine receptor mutation (G4946E) in diamondback moth populations

“…The leaf-dipping bioassay method using Brassica rapa L. leaves was applied. 3) In each bioassay, 5-7 concentrations of flubendiamide (0.02-2000 mg/L) and of chlorantraniliprole (0.005-500 mg/L) were tested. After 96 hr, the numbers of dead or moribund larvae and surviving larvae were recorded.…”

Synthesis and biological activity of a novel acaricide, pyflubumide

“…3,4) Meanwhile, a novel insecticide 2 with a unique heptafluoroisopropyl substituent was reported by our colleague. 5,6) We initially designed and synthesized a hybrid analogue 3 with substituents characteristic in such fungicides and insecticides together, but it showed only low fungicidal activity. It seemed that this low fungicidal activity was attributed to the high lipophilicity of derivative 3.…”

Management of brinjal shoot and fruit borer, Leucinodes orbonalis (Lepidoptera: crambidae) using some selected insecticides in field condition, Bangladesh

“…The yield loss caused by this pest is enormous and varies from 37% to 63% in different parts of India (Dhankar, 1988), up to 67% every year in Bangladesh (Islam & Karim, 1991). Latif, 2007 reported that Nimbicidene and Flubebdiamite were comparatively safe for natural enemies and insect pest management of brinjal on the other hand, Tohnishi et al (2005) reported that flubendiamide was highly toxic to Lepidopteran insect pests but it was very safe for different natural enemies like ladybird beetles, spiders, parasitic wasp, lacewings, predatory bug and predatory mite.…”