Flowability Properties of Labisia Pumila Herbal Powder

Etti, Christopher Joseph; Yusof, Yus Aniza; Chin, Nyuk Ling; Tahir, Suraya Mohd

doi:10.1016/j.aaspro.2014.11.018

Cited by 8 publications

(5 citation statements)

References 22 publications

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“…A. paniculata powder had highest cohesion index which leads to very poor flowability. These results were proven by Etti et al (2014) on flowability properties of L. pumila powder (Etti et al, 2014). In Figure 1, O. stamineus curve was slightly decreased in compaction coefficient with increasing tip speed compared to others hence; O. stamineus was tip speed dependent.…”

Section: Resultssupporting

confidence: 57%

“…The Carr index value was exceed 1.60 and Hausner ratio, HR was over 38.0% which prove the powder to be very difficult to flow (Carr, 1965), (Hausner, 1967). The difficulty on flow of these herbal powders was due to its very small particle size and high moisture content (Etti et al, 2014). Hence, the powders tend to absorb moisture and become cohesive that led to poor flowability.…”

Section: Resultsmentioning

confidence: 99%

“…The tabletting process can be divided into three stages; (a) the powder is filled into the die cavity, (b) a compaction process takes place which involves compression and decompression of the powder bed, and (c) the compacted powder is ejected from the die in the form of a tablet after the required height is obtained (Wu et al, 2008). There are large numbers of studies regarding the herbal based drug on their characteristics either in physical as well as chemical properties which include tablet compression, tablet dissolution, chemical compound investigation, and so on (Ali, Yusof, Chin, & Ibrahim Muneer, 2018; Etti, Yusof, Chin, & Mohd Tahir, 2014). In the local Malaysian context, herbs such as Long Jack or Eurycoma longifolia Jack, Labisia pumila , Orthosiphon stamineus , Andrographis paniculata Nees, Ficus deltoidea , Morinda citrifolia , and others are popular for their therapeutic properties.…”

Section: Introductionmentioning

confidence: 99%

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Compaction, flowability, and dissolution kinetics of Andrographis paniculata, Eurycoma longifolia, Labisia pumila, and Orthosiphon stamineus powders

Roslan

Yusof

Ali

et al. 2021

J Food Process Engineering

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The herbal powders included Andrographis paniculata, Eurycoma longifolia, Labisia pumila, and Orthosiphon stamineus are well known due to their therapeutic properties and usually consumed as herbal supplement that is available in different forms. The aim of this work was to investigate the compaction, flowability, and dissolution kinetics of selected herbal powders in the form of tablets and powders. A universal testing machine with forces ranging of 4.0–9.8 kN was used to compress the herbal powders in a 13 mm cylindrical uniaxial die. The compacted tablets were dissolved in three different mediums; distilled water, simulated saliva, and hydrochloric acid solution as to create the environment in drinking water, human mouth, and gastric fluid, respectively. The dissolution profile was compared based on the best fitting of mathematical model equations. The results shown that the dissolution of all selected herbal powders in all three dissolution mediums was best fitted in Korsmeyer–Peppas Model, Zero Order Kinetic Model, and Weibull Model, and tablets were completely dissolved within 2–6 min in all three mediums. It can be further tested with another type of powders. The data are essential in predicting the compaction, flow characteristics, and dissolution kinetics of herbal powders. Practical Applications Dried herbs are being used as natural remedy but their fluffy and sticky textures make them difficult to convert into a standard form of medicine like tablet or capsules. Flowablity, compressibility, and dissolution kinetics of any kind of herbal powder are the basic parameters to convert into tablet, capsule of pouch filling. Therefore, four Malaysian herbal powders were selected to process into different forms such as tablet, capsules, and cereal formulations. For this purpose, a comprehensive study has been carried out to increase the understanding of flow, compression, and dissolution characteristics of selected Malaysian herbal powders. The findings of the present study can also be applied to other herbs and leaves powders. The findings of present research work provides basic fundamentals for nutraceutical industry to produce better quality herbal powder, easy to handle, transport, and store and convert them into a standard form of tablet or capsules.

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Section: Resultssupporting

confidence: 57%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Compaction, flowability, and dissolution kinetics of Andrographis paniculata, Eurycoma longifolia, Labisia pumila, and Orthosiphon stamineus powders

Roslan

Yusof

Ali

et al. 2021

J Food Process Engineering

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“…Flowability was evaluated using the Carr index and Hausner's index. 25,26 Pharmacologic and technological properties of powders and granulates…”

Section: Methods Of Analysis Of Lavender Oil In "Lavaflam" Tabletsmentioning

confidence: 99%

Development of the composition and manufacturing technology of the new combined drug Lavaflam

Івко

Aslanian

Bobrytska

et al. 2018

tjps

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Biliyer sistem hastalıklarının tedavisi, modern tıbbın acil problemlerinden biridir. Gereç ve Yöntemler: Biliyer sistem hastalıklarının karmaşık tedavisi için, bitkisel bileşenler flamin (0.05 g) ve lavanta yağından (0.02 g) oluşan bir bileşimi içeren kombine tablet formundaki formdaki orijinal farmasötik ilaç "Lavaflam" önerilmiştir. Flamin, flavonoidler grubundan (salipurposid, isosalipurposide, kaempferol, luteolin) aktif maddelerden oluşan bir kompleks içeren, ölmez çiçeklerden [Helichrysum arenarium (L.) Moench, Asteraceae] elde edilen bitkisel kaynaklı ilaçtır. Kolesistit, kolanjit ve biliyer diskinezide koloretik ve anti-inflamatuvar ajan olarak uygulanır. Tabletler, ayrı granülasyon teknolojisi için preslenerek hazırlandı. Bulgular: Lavanta yağı granülesi katı faz metodu kullanılarak hazırlandı ve β-siklodekstrin yardımcı madde olarak kullanıldı. Flamin granülesi küresel şekilli dolgu maddesi mannitol PARTECK M 200 ile karıştırılarak hazırlandı. Önceki çalışmalara dayanarak, tasarlanan "Lavaflam" tablet bileşiminin eksipiyanları, β-siklodekstrin (0.27 g), mannitol PARTECK M 200 (0.20 g), kroskarmeloz sodyum (0.03 g), patates nişastası (0.022 g), PEG 6000 (0.002 g) ve magnezyum stearat (0.006 g) idi. Lavanta yağının ana bileşenlerinin analizi linalol ve linalil asetat referansları ile, gaz kromatografisi kullanılarak gerçekleştirildi. Flaminin toplam flavonoidlerinin analizi, referans olarak isosalipurposid ile spektrofotometri kullanılarak gerçekleştirildi. Sonuç: Yeni bitkisel kaynaklı tabletler "Lavaflam", Avrupa Farmakopesi gereksinimlerini aşağıdaki parametrelerle karşılamaktadır: görünüm, geometrik boyut, ortalama ağırlık, dağılma, ufalanabilirlik, tabletlerin kırılmaya karşı direnci ve miktar tayini. Anahtar kelimeler: Lavanta yağı, flamin, Lavaflam tabletleri Objectives: Treatment of diseaes of the biliary system is one of the urgent problems of modern medicine. Materials and Methods: An original pharmaceutical drug "Lavaflam" in the form of combined tablets, which includes a composition of herbal components flamin (0.05 g) and lavender oil (0.02 g), was proposed for the complex treatment of diseases of the biliary system. Flamin is phytomedicine from the immortelle flowers [Helichrysum arenarium (L.) Moench, Asteraceae], which contains a complex of active substances from the flavonoids group (salipurposide, isosalipurposide, kaempferol, luteolin). It is applied as a choleretic and an anti-inflammatory agent in cholecystitis, cholangitis, and biliary dyskinesia. Tablets were prepared by pressing for separate granulation technology. Results: The lavender oil granulate was prepared using the solid phase method, and β-cyclodextrin was used as an excipient substance. The flamin granulate was prepared by mixing with the spherical-shaped filler mannitol PARTECK M 200. On the basis of previous studies, the excipients of the designed composition tablet "Lavaflam" were β-cyclodextrin (0.27 g), mannitol PARTECK M 200 (0.20 g), croscarmellose sodium (0.03 g), potato starch (0.022 g), PEG 6000 (0.002 g), and m...

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“…Flow characteristics of powder samples were determined by finding the Hausner ratio (HR) (Hausner, 1981) and Carr index (CI) (Etti, Yusof, Chin, & Tahir, 2014). It was estimated by using Equations ( 15) and ( 16), where ρ t and ρ B represented the tapped and bulk density.…”

Section: Flow Characteristics Of Tray Dried Biomass and Ftir Analysismentioning

confidence: 99%

Production of Oscillatoria sp. BTA‐170 biomass in photobioreactor: Analysis of composition, drying behavior, sorption isotherm, and powder flow characteristics

Sharma

Nath

Pabbi

et al. 2022

J Food Process Engineering

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In this study, Oscillatoria sp. BTA-170 was grown in a photobioreactor for 15 days, yielding 3.1 g/L of biomass. During the composition analysis of biomass, the moisture, protein, carbohydrate, lipid, and ash contents were found to be 83.27, 6.36, 5.48, 3.79, and 1.1% on a wet basis (w.b), respectively. The tray drying properties of cyanobacterial biomass were investigated at temperatures of 40, 60, and 80 C with constant air velocity of 0.6 m/s. To reduce the moisture content of biomass from 83.27% to <10%, drying time required 2, 12, and 30 hr at 80, 60, and 40 C, respectively. The calculated effective moisture diffusivity of biomass was 5.10 Â 10 À9 , 6.34 Â 10 À8 , and 2.30 Â 10 À7 m 2 /s at 40, 60, and 80 C, respectively, and the activation energy was found to be 28.01, 31.04, and 33.27 kJ/mol at 40, 60, and 80 C, respectively. The logarithmic and Henderson and Pabis models showed the highest R 2 values of 0.997 and 0.996 at 80 C, respectively, and were thus employed to explain biomass drying characteristics. The drying constant value grew with increasing temperature, with the highest value obtained using the logarithmic model at 80 C being 0.523 (hr À1 ). The bulk density of biomass powder dried at 80 C was 598.21 kg/m 3 and the tapped density was 652.80 kg/m 3 , with Hausner ratio and Carr index of 1.091 and 8.363, respectively, showing that biomass powder had excellent flow qualities. The dried cyanobacterial biomass is a great source of protein, according to FTIR measurements. Similarly, after selecting four models based on the sorption isotherm, the GAB model was shown to be the best fit to represent the sorption behavior of Oscillatoria sp. BTA-170 powder. Practical ApplicationsThe drying characteristics of Oscillatoria sp. BTA-170 biomass were evaluated using thin-layer drying models. The primary goal of drying biomass is to remove water from the solids to a point where microorganisms and degradation chemical processes are considerably reduced. The analysis of drying properties aids in the development of a cost-effective dryer. By hastening the manufacture of biomass powder, the effective design of the drying process helps to decrease time and processing costs. After the drying process, an FTIR analysis can be used to determine the presence of

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Flowability Properties of Labisia Pumila Herbal Powder

Cited by 8 publications

References 22 publications

Compaction, flowability, and dissolution kinetics of Andrographis paniculata, Eurycoma longifolia, Labisia pumila, and Orthosiphon stamineus powders

Compaction, flowability, and dissolution kinetics of Andrographis paniculata, Eurycoma longifolia, Labisia pumila, and Orthosiphon stamineus powders

Development of the composition and manufacturing technology of the new combined drug Lavaflam

Production of Oscillatoria sp. BTA‐170 biomass in photobioreactor: Analysis of composition, drying behavior, sorption isotherm, and powder flow characteristics

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