Flow Technologies for Efficient Separations

Advances in in situ and in-line liquid–liquid extraction for bioprocess intensification

“…After the mass transfer, the two phases can then be separated, generally by a density or surface force difference. 15 The partitioning of solutes in the two phases depends on solute–solvent interactions, such as ionic interaction, dispersion, dipole–dipole interaction, induced-dipole interaction, and hydrogen bond. 16 There are different ways to classify LLE in bioprocesses, such as mechanisms, solvent systems, and operating modes, as shown in Fig.…”

Continuous Separation and Purification of Chemical Species by Continuous Liquid–Liquid Partition Chromatography Implemented with Membrane-Based Phase Separators

“…As the wetted parts of membrane-based separators can be made of fully perfluorinated polymers, there are also no pH limitations when using these separators. Membrane separators have also been proven to be easily scalable with no loss in the extraction efficiency; as long as the phases entering the separator are at equilibrium, equivalent extraction can be achieved across scales. , Membrane-based separators have also been proven to be fully density independent contributing to their robustness.…”