Flow-mediated dilatation has an additive value to stress ECG for the diagnosis of angiographically significant coronary atherosclerosis

Симова, Яна; Katova, Tsvetana; Денчев, Стефан; Dimitrov, Nikolay

doi:10.1016/j.jash.2010.06.001

Cited by 5 publications

(2 citation statements)

References 9 publications

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“…This suggests that FMD value ≤10 could identify true negatives. Similar findings were noted by Simova I et al 33 in their study. Armin Arbab-Zadeh 34 reported sensitivity of 68% and specificity of 77%.…”

Section: Discussionsupporting

confidence: 92%

Correlation of endothelial dysfunction measured by flow-mediated vasodilatation to severity of coronary artery disease

Sancheti¹,

Shah²,

Phalgune³

2018

Indian Heart Journal

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Objectives Brachial artery ultrasound imaging during reactive hyperemia is widely used tool for quantifying endothelium dependent vasomotion. Angiodefender device is used for non invasive determination of percentage flow mediated vasodilation (FMD). An attempt is made to study whether endothelial dysfunction determined by FMD of brachial artery predicts the presence or absence of coronary artery disease and its correlation with the severity of coronary artery disease. Methods One hundred six patients admitted between May 2014 and April 2015 who were posted for coronary angiography diagnosed to have chronic stable angina on clinical basis and/or by exercise stress test, for evaluation of coronary artery disease were submitted to standard clinical evaluation, calculation of percentage FMD by Angiodefender device. Statistical significance of difference of categorical variables was tested using Fisher’s exact test. Sensitivity, specificity, positive predictive value and negative predictive value of FMD were studied. Results There was no correlation between number of risk factors and percentage of FMD. Significantly higher proportion of cases with less FMD had higher prevalence of coronary artery disease and vice-versa. Significantly higher proportion of cases with positive stress test had less percentage of FMD and vice-versa. Significantly higher proportion of cases with less percentage of FMD and positive stress test had higher prevalence of obstructive coronary artery disease and vice-versa. Specificity was 100% when percentage of FMD was ≤10. Conclusions FMD an inexpensive and non-invasive test provides information regarding extent and severity of coronary artery disease.

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Section: Discussionsupporting

confidence: 92%

Correlation of endothelial dysfunction measured by flow-mediated vasodilatation to severity of coronary artery disease

Sancheti¹,

Shah²,

Phalgune³

2018

Indian Heart Journal

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“…FMD was expressed as the percentage change in vessel diameter during reactive hyperemia (10). Although a universally accepted threshold for defi ning a normal vs. abnormal FMD response has not been proposed, currently available evidence indicates that the ideal cut-off value may be around fi ve percent (15)(16)(17)(18)(19). Based on the previous studies, a FMD value < 5% and ≥ 5% was accepted as abnormal and normal FMD response.…”

Section: Evaluation Of Fl Ow Mediated Dilatationmentioning

confidence: 99%

A high oxidative stress index predicts endothelial dysfunction in young male smokers

Karahan¹,

Manduz²,

Bektaşoğlu³

et al. 2013

BLL

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Abstract:Experimental studies have shown that smoking was related to endothelial dysfunction via oxidative stress. However, the degree of oxidative stress to be associated with endothelial dysfunction is unknown. Oxidative stress index (OSI) might be a useful and easy way of determining the endothelial dysfunction. Hence, we aimed to evaluate the relationship between OSI and fl ow mediated dilatation (FMD) in smoking healthy male volunteers. Eighty smoking healthy male volunteers were enrolled in the study. Participants were classifi ed as having normal and abnormal FMD response. In an univariate analysis; systolic and diastolic blood pressures, Creactive protein (CRP), low-density lipoprotein cholesterol, OSI and lipid peroxidation (LPO) levels were predictive for abnormal FMD response. In a multivariable logistic regression analysis with forward stepwise method, OSI (OR: 3.194, 95% CI: 1.710-5.966, p<0.001) and CRP (OR: 2.082, 95% CI: 1.101-3.939, p 0.024) were found to be independent parameters for predicting abnormal FMD response in young male smokers. The optimal cut-off value of OSI for detecting abnormal FMD response was found to be >3.35, with 100 % sensitivity and 84.1 % specifi city. We have shown that critical endothelial dysfunction can easily be detected by OSI in individuals, at risk for developing coronary artery disease, such as smokers (Tab. 3, Fig. 3, Ref. 30). Text in PDF www.elis.sk.

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Household Air Pollution from Solid Fuel Use: Evidence for Links to CVD

McCracken

Wellenius

Bloomfield

et al. 2012

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Flow-mediated dilatation has an additive value to stress ECG for the diagnosis of angiographically significant coronary atherosclerosis

Cited by 5 publications

References 9 publications

Correlation of endothelial dysfunction measured by flow-mediated vasodilatation to severity of coronary artery disease

Correlation of endothelial dysfunction measured by flow-mediated vasodilatation to severity of coronary artery disease

A high oxidative stress index predicts endothelial dysfunction in young male smokers

Household Air Pollution from Solid Fuel Use: Evidence for Links to CVD

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