Flow-Mediated Arterial Dilation in Primary Antiphospholipid Syndrome

Abstract

APS correlates closely with precocious atherosclerosis, and the correlation with a type of anticardiolipin antibody may be predictive of more accelerated atherosclerosis.

Carotid Atherosclerosis and Flow Mediated Dilatation in the Brachial Artery in Patients with Antiphospholipid Syndrome: A Case-control Study

“…It is already known that anticardiolipin antibodies also have a role in coagulation alteration and in endothelial changes [8,9] and this can well explain our results.…”

“…DISCUSSION In a previous case-control study conducted by our Department, results evidenced that subjects with PAPS presented a greater IMT and a reduced FMD respect a control group. In addition these alterations could be correlated with antiphospholipid antibodies [8].…”

Association between peripheral vascular endothelial dysfunction and livedoid vasculopathy

“…Impaired FMD has been shown in atherosclerosis, hypertension, diabetes mellitus, and cardiovascular disease, and in autoimmune disease 6,22 and antiphospholipid syndrome. 23,24 Endothelial dysfunction is one of the earliest stages of atherogenesis, preceding the formation of atherosclerotic plaques, and has been shown to be a risk factor for cardiovascular disease. The high prevalence of atherosclerosis and cardiovascular disease in autoimmune disease supports the hypothesis of an association between these diseases.…”

Atherosclerosis in Primary Antiphospholipid Syndrome: Summary of Clinical and Pathogenic Evidence

“…An abnormal ankle-brachial-index was more common in PAPS (19%) than in healthy controls group (4%) though these findings were not corrected for confounders such as hypertension, obesity and hypercholesterolaemia [18]. Flow mediated vasodilatation was consistently lower in PAPS than in controls particularly in patients with arterial disease [8,9,[19][20][21][22].…”