Association between peripheral vascular endothelial dysfunction and livedoid vasculopathy

Yang, Cheng; Shen, Su‐Chin; Hui, Rosaline Chung‐Yee; Huang, Yu‐Huei; Chu, Pao‐Hsien; Ho, Wan-Jing

doi:10.1016/j.jaad.2011.07.021

Cited by 15 publications

(10 citation statements)

References 36 publications

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“…In our study, the mean age of onset was in the fifth decade of life which is similar to the previous studies of Piamphongsant et al [10] (mean age = 40.8 years). The Onset of disease ranged from <1 to 8 years and the mean duration of pemphigus was found to be 29.85±25.97 which is similar to Yu-Huei Huang et al [11]. The mean BMI was 22.05±3.72.…”

Section: Discussionsupporting

confidence: 80%

A preliminary study on clinical outcome of corticosteroid therapy in pemphigus patients

Vijayakumar¹,

P²,

Sasikala³

et al. 2014

Our Dermatol Online

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Introduction: Pemphigus is life threating blistering of autoimmune disease of the skin and mucous membrane characterised by autoantibodies (auto ABs) against desmoglein-3 (DSG-3). Desmosomal adhesions, protein expressed on the surface of epidermal keratinocytes. Aim: The present study was to assess the incidence rate of pemphigus, to evaluate the clinical course along with clinical manifestations, Complications and Metabolic factors of patients with pemphigus and to investigate the disease severity and induction of remission during the clinical course and whereas to assess the oxidative stress and antioxidant status in pemphigus patients in our hospital. Material and Methods: A prospective study was conducted over a period of January 2012 to December 2012 at dermatology department, MGM Hospital, Warangal. The data was collected from 32 cases of Pemphigus on the basis of Age, Sex, Social Habits, BMI, Histopathological forms, Clinical manifestations and Drug therapy. This hospital is 1200 bedded government hospital provided Outpatient and Inpatient care for Indian citizen especially in Telangana region free of cost. Results: Of the 32 pemphigus patients, 75% were diagnosed with Pemphigus Vulgaris (PV), 12.5% with Pemphigus Foliaceus (PF) and 12.5% with Bullous Pemphigoid (BP). The male to female ratio was approximately 1:1.3. The mean age of onset was 40.8 years in Pemphigus patients. The Onset of disease was 29.85. 34% of patients with Pemphigus had both the mucosal and skin involvement during the clinical course while 25% at the onset of disease. The most common complication was found to be increase blood sugar (40%). Most commonly prescribed adjuvant is dapsone. Majority attained the complete remission and remaining of them attains partial remission. Oxidative stress levels were higher and antioxidant status levels were lower in study subjects when compared to controls. Conclusions: PV is the most common subtype of Pemphigus in our Hospital and usually affects females more than males. Our study reveals that mucosal and skin involvement is common. Corticosteroids and dapsone as adjuvant is majorly prescribed. Most of patients attain complete remission and remaining of them achieves partial remission. Oxidative stress levels were higher and antioxidant status levels were lower in our study subjects when compared to controls.

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Section: Discussionsupporting

confidence: 80%

A preliminary study on clinical outcome of corticosteroid therapy in pemphigus patients

Vijayakumar¹,

P²,

Sasikala³

et al. 2014

Our Dermatol Online

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“…Oxidized Lp(a) impairs endothelium‐dependent vasodilatation through O 2 formation and subsequent nitric oxid inactivation and may also justify the impairment of flow‐mediated vasodilation observed in LV patients …”

Section: Discussionmentioning

confidence: 99%

“…23 Oxidized Lp(a) impairs endothelium-dependent vasodilatation through O 2 formation and subsequent nitric oxid inactivation 24 and may also justify the impairment of flow-mediated vasodilation observed in LV patients. 25 Moreover, Lp(a) may explain the response of patients with LV to the anabolic steroids danazol and stanozolol, which significantly reduce serum levels of Lp(a). 26 We suggest that the initiating event may be the aggravation of The Mann-Whitney U test was used to assess the differences between groups and gender.…”

Section: Discussionmentioning

confidence: 99%

Analysis of serum levels and cutaneous expression of lipoprotein (a) in 38 patients with livedoid vasculopathy

et al. 2017

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“…The uses of vasodilators such as nifedipine, cilostazol, nicotinic acid, and dipyridamole have been reported as adjuvant therapy for LV (6,47). Yang et al recently found that peripheral vascular endothelial dysfunction was demonstrated in patients with LV by reduction of brachial flow-mediated vasodilation (48). This finding supports the use of vasodilating agents in the treatment of LV.…”

Section: Vasodilatorsmentioning

confidence: 84%

Update of management of connective tissue diseases: livedoid vasculopathy

Gonzalez-Santiago

Davis

2012

Dermatol Ther

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: Livedoid vasculopathy (LV) is characterized by painful purple macules and papules that subsequently ulcerate. The lesions heal over weeks to months resulting in smooth, porcelain‐white, atrophic plaque‐like areas with surrounding telangiectases and hyperpigmentation. The specific cause of LV is still to be determined and it is believed to be multifactorial in nature. Despite numerous available therapeutic agents, there is not a single best efficacious treatment for LV. Most of the available treatment options are based on isolated case reports or case series. In this article, studies on the pathogenesis and therapeutic approaches to LV are reviewed.

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Association between peripheral vascular endothelial dysfunction and livedoid vasculopathy

Cited by 15 publications

References 36 publications

A preliminary study on clinical outcome of corticosteroid therapy in pemphigus patients

A preliminary study on clinical outcome of corticosteroid therapy in pemphigus patients

Analysis of serum levels and cutaneous expression of lipoprotein (a) in 38 patients with livedoid vasculopathy

Update of management of connective tissue diseases: livedoid vasculopathy

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