Flow‐injection chemiluminescence determination of ofloxacin using the Ru(bpy)₂(CIP)²⁺−Ce(IV) system and its application

Abstract

This paper reports a flow-injection chemiluminescence method for the determination of ofloxacin (OFLX) using the Ru(bpy)2(CIP)2+-Ce(IV) system. Under the optimum conditions, the relative CL intensity was proportional to the concentration of OFLX in the range 3.0 x 10(-8)-1.0 x 10(-5) mol/L and the detection limit was 4.2 x 10(-9) mol/L. The proposed method has been successfully applied to the determination of ofloxacin in pharmaceuticals and human urine. The chemiluminescence mechanism of the system is also discussed.

Analytically useful blue chemiluminescence from a water-soluble iridium(iii) complex containing a tetraethylene glycol functionalised triazolylpyridine ligand

“…S4 †), have previously been shown to elicit light upon reaction with various ruthenium(II) and iridium(III) complexes under acidic conditions using cerium(IV) sulfate as an oxidant. 9,18,19 Similar trends in the relative chemiluminescence intensities (and signal-to-blank ratios) were observed across the different reagent concentrations (Fig. 3 and S5 †), but the three reagents exhibited markedly different selectivity.…”

Pharmaceuticals and Related Drugs

“…Besides the many direct read spectrophotometric appoaches, spectrophotometry in combination with segmented flow (flow injection analysis) also has been used to assay many different types of pharmaceutical formulations. Examples of a few of these procedures along with examples of other types of flow injection assays (FIA) are given in Table − . Although many of them employ standard flow through detection, some use custom designed optical sensors to read the analyte signal in combination with different types of analyte−sensor/cell construction.…”

Quinolone Complexes with Lanthanide Ions: An Insight into their Analytical Applications and Biological Activity

“…The source of the electromagnetic radiation necessary to obtain the excited state of the ligand is either the Xe lamp of the spectrofluorometer, or a chemical species in an excited state, such as SO 2 * obtained through a chemical reaction (chemiluminiscence). Numerous methods have been developed for the determination of quinolones [100][101][102][103][104][105][106][107][108][109], based on the formation of an excited and unstable chemical species in a redox system. This chemical species emits radiation capable of being absorbed by the fluoroquinolone.…”