Flow focusing pneumatic nebulizer in comparison with several micronebulizers in inductively coupled plasma atomic emission spectrometry

Almagro, Beatriz; Gañán‐Calvo, Alfonso M.; Hidalgo, Montserrat; Canals, Antonio

doi:10.1039/b518282d

Cited by 24 publications

(16 citation statements)

References 64 publications

(71 reference statements)

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“…Using this configuration, 197 Au + sensitivity for a sample uptake rate of 0.6 mL min -1 were 3-fold higher than those obtained using the standard nebulizer provided with the instrument (i.e., Micromist, Glass Expansion, Australia). These results were the expected taking into account the higher aerosol generation efficiency of the former nebulizer when operating at sample uptake rates in the order of L min -1 (Almagro, Gañán-Calvo, Hidalgo, & Canals, 2006). Initially, samples were tried to introduce into the spectrometer using self-aspirating conditions (i.e., without using a peristaltic-pump) as suggested by Giesen et al (2010).…”

Section: Icp-ms Instrumentationmentioning

confidence: 71%

Determination of aflatoxin M1 in milk samples by means of an inductively coupled plasma mass spectrometry-based immunoassay

et al. 2017

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An inductively coupled plasma mass spectrometry (ICP-MS)-based immunoassay has been developed to quantify aflatoxin M1 (AFM1) at ultra-trace levels in milk samples. AFM1 detection is carried out by means of a competitive immunoassay using secondary biotinylated antibodies and streptavidin-conjugated Au nanoparticles. After acid addition, nanoparticles are decomposed and Au signal is registered by means of ICP-MS. Results demonstrate that, under optimum conditions, the limit of detection of the immunoassay (0.005μgkg) is low enough to quantify AFM1 according to current international policies (including the more restrictive European one). Method accuracy and precision was checked by analyzing an AFM1 certified reference material and different milk samples spiked with known amounts of AFM1. AFM1 recovery values range from 80% to 102% whereas inter-assay and intra-assay precision are lower than 15%. Finally, this immunoassay methodology affords a higher dynamic working range (0.012-2.5μgkg) than other immunoassay methodologies described in the literature.

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Section: Icp-ms Instrumentationmentioning

confidence: 71%

Determination of aflatoxin M1 in milk samples by means of an inductively coupled plasma mass spectrometry-based immunoassay

et al. 2017

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“…Usually an aerosol is generated by a nebulizer and transported to the plasma through a spray chamber [4,6]. However, most commonly used systems show some drawbacks such as low transport efficiency, high sample consumption, clogging with high salt content matrices and matrix effects in As and Se determination in presence of easily ionized elements (EIEs) [4,[7][8][9][10]. Many strategies were developed in order to overcome these limitations, such as hydride generation (HG) for hydride-forming elements and modified sample introduction systems.…”

Section: Introductionmentioning

confidence: 99%

Aerosol generation of As and Se hydrides using a new Flow Blurring® multiple nebulizer for sample introduction in inductively coupled plasma optical emission spectrometry

Pereira

Aguirre

Nóbrega

et al. 2014

Microchemical Journal

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A new Flow Blurring ® multiple nebulizer (FBMN) has been used for the efficient generation of As and Se hydrides directly into the aerosol formed inside the spray chamber before detection by inductively coupled plasma optical emission spectrometry (ICP OES). The FBMN allowed the hydrides generation directly into the spray chamber without using any additional device either for solution and gases control or for gas phase separation. Synthetic solutions containing As and Se plus Ca, Mg and K were used for evaluating matrix effects and Ge was suggested as internal standard. Limits of detection of 2.7 and 5.8 µg L-1 were obtained for As and Se, respectively, when keeping the nebulization gas flow rate at 0.60 L min-1 and the liquid flow rate at 0.67 mL min-1. The developed procedure was applied for spiked digests of food samples and quantitative recoveries were attained. The combination of FBMN, internal standard and hydride generation is a robust and simple approach for generating As and Se hydrides directly into the aerosol.

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“…This increases sample transport efficiency to the plasma and, therefore, improves the analytical performance of the nebulizers in ICP-OES, ICP-Mass Spectrometry (MS) and Microwave Induced Plasma (MIP)-OES when compared to other commercially available nebulizers. [5][6][7][8][9] The second important drawback of ICP-OES is related to the so-called non-spectral interferences or matrix effects [10][11][12] (and references therein). The type of calibration used in the analysis plays a crucial role in minimizing matrix effects.…”

Section: Introductionmentioning

confidence: 99%

Compensation for matrix effects on ICP-OES by on-line calibration methods using a new multi-nebulizer based on Flow Blurring® technology

Aguirre

Kovachev

Almagro

et al. 2010

J. Anal. At. Spectrom.

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In this work, on-line calibration methods were applied for compensation for matrix effects in Inductively Coupled Plasma-Optical Emission Spectrometry (ICP-OES) using three novel multiple sample introduction systems based on Flow Blurring Ò technology. The methods were compared with conventional calibration methods, using a Conikal nebulizer and a cyclonic spray chamber (i.e., Standard Sample Introduction (SSI) system). Experiments were carried out with synthetic samples containing different matrices. The total liquid flow through the multinebulizers was 400 mL min À1 whereas in the SSI system it was 1000 mL min À1 . One type of calibration method tested was external calibration. By using this calibration method, the mean of absolute values corresponding to the relative error values of different multiple sample introduction systems and all the matrices was 14% and uncertainty was 0.6%. When on-line internal standard calibration was used, the mean relative error value dropped to 3% and uncertainty was 0.6%. With on-line standard addition calibration, relative error values went down to 2%. However, uncertainty values increased to 2% in all cases. With all the calibration methodologies, the accuracy and uncertainty of the obtained results were very similar for both standard and multiple sample introduction systems. The main difference was a significant reduction in resource consumption (i.e., samples, reagents and time) when multinebulization systems were used. Sensitivity, precision and limits of detection were evaluated for the different Flow Blurring Ò based systems and SSI system. For most of the emission lines evaluated, all the Flow Blurring Ò based systems gave higher precision values and lower limits of detection than SSI system. A certified reference material (Estuarine Water, LGC6016), without prior sample treatment (i.e., dilution), was analyzed using external calibration with the SSI system and on-line standard addition calibration with Flow Blurring Ò based systems. The certified reference material analysis gave relative error values ranging between +20% and À30% for the SSI system, and between +4% and À2% for Flow Blurring Ò based systems.

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Flow focusing pneumatic nebulizer in comparison with several micronebulizers in inductively coupled plasma atomic emission spectrometry

Cited by 24 publications

References 64 publications

Determination of aflatoxin M1 in milk samples by means of an inductively coupled plasma mass spectrometry-based immunoassay

Determination of aflatoxin M1 in milk samples by means of an inductively coupled plasma mass spectrometry-based immunoassay

Aerosol generation of As and Se hydrides using a new Flow Blurring® multiple nebulizer for sample introduction in inductively coupled plasma optical emission spectrometry

Compensation for matrix effects on ICP-OES by on-line calibration methods using a new multi-nebulizer based on Flow Blurring® technology

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