Flow fields and vortex dynamics of bubbles collapsing near a solid boundary

Reuter, Fabian; Gonzalez-Avila, Silvestre Roberto; Mettin, Robert; Ohl, Claus‐Dieter

doi:10.1103/physrevfluids.2.064202

Cited by 69 publications

(61 citation statements)

References 69 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These cavitation filaments (streamers) match the locations of satellite microbubbles that extend normally out from the surface of the largest bubble in its final stage before the collapse. Similar phenomenon was detected by Supponen et al [19], due to the interplay of the shock wave with the fast flowing water, revealing the streamlines of the flow [38]. An already known phenomenon, dubbed counter jet, is clearly visible in Fig.…”

Section: Effects Of Breakdown Distancesupporting

confidence: 82%

“…6(k), the conglomerated remnant gas pockets move anteriorly and persist in water on timescale of seconds. Their motion can be observed by a naked eye and is caused by the 'wall vortex' induced during the asymmetric collapse [38]. In the presented experiments, they ascend to the water surface due to buoyance, but in the eye, if formed in the vitreous, they move against the gravity until they are brought to stop at the boundary of the posterior chamber.…”

Section: Implications In Ophthalmologymentioning

confidence: 79%

“…Smaller energy at the breakdown produces the main bubble of smaller maximum diameter and shorter duration of its first oscillation. Apart from the influence of the vicinity of the solid boundary, which prolongs the duration of the first bubble oscillation [38], this is the main reason why earlier frames in Figs. 6(l)-6(v) were chosen for presentation at larger breakdown distances.…”

Section: Effects Of Breakdown Distancementioning

confidence: 98%

“…6(n). This is another secondary cavitation entity (a gaseous phase, not a liquid jet) generated by the shock wave emitted at the bubble collapse [38]. It extends along the axis of symmetry from the point of collapse in the direction away from the solid boundary.…”

Section: Effects Of Breakdown Distancementioning

confidence: 99%

See 3 more Smart Citations

Cavitation induced by shock wave focusing in eye-like experimental configurations

Požar

Petkovšek

2019

Biomed. Opt. Express

View full text Add to dashboard Cite

During laser-induced, breakdown-based medical procedures in human eyes such as posterior capsulotomy and vitreolysis, shock waves are emitted from the location of the plasma. A part of these spherically expanding transients is reflected from the concave surface of the corneal epithelium and refocused within the eye. Using a simplified experimental model of the eye, the dominant secondary cavitation clusters were detected by high-speed camera shadowgraphy in the refocusing volume, dislocated from the breakdown position and described by an abridged ray theory. Individual microbubbles were detected in the preheated cone of the incoming laser pulse and radially extending cavitation filaments were generated around the location of the breakdown soon after collapse of the initial bubble. The generation of the secondary cavitation structures due to shock wave focusing can be considered an adverse effect, important in ophthalmology.

show abstract

Section: Effects Of Breakdown Distancesupporting

confidence: 82%

Section: Implications In Ophthalmologymentioning

confidence: 79%

Section: Effects Of Breakdown Distancementioning

confidence: 98%

Section: Effects Of Breakdown Distancementioning

confidence: 99%

See 2 more Smart Citations

Cavitation induced by shock wave focusing in eye-like experimental configurations

Požar

Petkovšek

2019

Biomed. Opt. Express

View full text Add to dashboard Cite

show abstract

“…Tho et al (2007) and Collis et al (2010) used micro-PIV to study the flow fields around a bubble undergoing stable cavitation; they found that many different microstreaming patterns were possible around a bubble, and each pattern generated different shear stress and stretch/compression distributions. Reuter et al (2017) used micro-PIV and high-speed cameras to study the flow fields and vortex dynamics of bubbles collapsing near a solid boundary. Their results showed that the flow patterns of transient cavitation included free and wall vortices and depended on the bubble stand-off distance.…”

Section: Introductionmentioning

confidence: 99%

Micro-Particle Image Velocimetry Investigation of Flow Fields of SonoVue Microbubbles Mediated by Ultrasound and Their Relationship With Delivery

Zou

Wang

et al. 2020

Front. Pharmacol.

View full text Add to dashboard Cite

The flow fields generated by the acoustic behavior of microbubbles can significantly increase cell permeability. This facilitates the cellular uptake of external molecules in a process known as ultrasound-mediated drug delivery. To promote its clinical translation, this study investigated the relationships among the ultrasound parameters, acoustic behavior of microbubbles, flow fields, and delivery results. SonoVue microbubbles were activated by 1 MHz pulsed ultrasound with 100 Hz pulse repetition frequency, 1:5 duty cycle, and 0.20/0.35/0.70 MPa peak rarefactional pressure. Micro-particle image velocimetry was used to detect the microbubble behavior and the resulting flow fields. Then HeLa human cervical cancer cells were treated with the same conditions for 2, 4, 10, 30, and 60 s, respectively. Fluorescein isothiocyanate and propidium iodide were used to quantitate the rates of sonoporated cells with a flow cytometer. The results indicate that (1) microbubbles exhibited different behavior in ultrasound fields of different peak rarefactional pressures. At peak rarefactional pressures of 0.20 and 0.35 MPa, the dispersed microbubbles clumped together into clusters, and the clusters showed no apparent movement. At a peak rarefactional pressure of 0.70 MPa, the microbubbles were partially broken, and the remainders underwent clustering and coalescence to form bubble clusters that exhibited translational oscillation. (2) The flow fields were unsteady before the unification of the microbubbles. After that, the flow fields showed a clear pattern. (3) The delivery efficiency improved with the shear stress of the flow fields increased. Before the formation of the microbubble/bubble cluster, the maximum shear stresses of the 0.20, 0.35, and 0.70 MPa groups were 56.0, 87.5 and 406.4 mPa, respectively, and the rates of the reversibly sonoporated cells were 2.4% ± 0.4%, 5.5% ± 1.3%, and 16.6% ± 0.2%. After the cluster formation, the maximum shear stresses of the three groups were 9.1, 8.7, and 71.7 mPa, respectively. The former two could not mediate sonoporation, whereas the Frontiers in Pharmacology | www.frontiersin.org last one could. These findings demonstrate the critical role of flow fields in ultrasoundmediated drug delivery and contribute to its clinical applications.

show abstract

Experimental assessment of cardiovascular physiology in the chick embryo

Sukumaran

Mutlu

Murtaza

et al. 2023

Developmental Dynamics

View full text Add to dashboard Cite

High resolution assessment of cardiac functional parameters is crucial in translational animal research. The chick embryo is a historically well‐used in vivo model for cardiovascular research due to its many practical advantages, and the conserved form and function of the chick and human cardiogenesis programs. This review aims to provide an overview of several different technical approaches for chick embryo cardiac assessment. Doppler echocardiography, optical coherence tomography, micromagnetic resonance imaging, microparticle image velocimetry, real‐time pressure monitoring, and associated issues with the techniques will be discussed. Alongside this discussion, we also highlight recent advances in cardiac function measurements in chick embryos.

show abstract

Flow fields and vortex dynamics of bubbles collapsing near a solid boundary

Cited by 69 publications

References 69 publications

Cavitation induced by shock wave focusing in eye-like experimental configurations

Cavitation induced by shock wave focusing in eye-like experimental configurations

Micro-Particle Image Velocimetry Investigation of Flow Fields of SonoVue Microbubbles Mediated by Ultrasound and Their Relationship With Delivery

Experimental assessment of cardiovascular physiology in the chick embryo

Contact Info

Product

Resources

About