Flow-controlled ventilation – a novel approach to treating acute respiratory distress syndrome

Bergold, Martin; Otterburg, Timo; Woitzik, Johannes; Byhahn, Christian

doi:10.1016/j.tacc.2019.12.231

Cited by 2 publications

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“…We tried to clarify potential applicability and advantages of this new ventilation modus in ARDS patients. This is one of the first studies of FCV in ARDS patients [ 18 , 20 ], where we showed FCV was feasible, albeit for a short period of time, and without obvious adverse events. Furthermore, FCV resulted in a similar oxygenation compared to VCV.…”

Section: Discussionmentioning

confidence: 79%

“…Literature about the use of FCV in ARDS patients and the effects of FCV on alveolar gas exchange in this population is limited to two case-reports and a published study protocol [ 18 – 20 ]. Therefore, the primary aim of our study was to investigate the effect of FCV on oxygenation compared to VCV in mechanically ventilated patients with ARDS due to a SARS-CoV-2 infection to assess feasibility of FCV in this patient population.…”

Section: Introductionmentioning

confidence: 99%

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Flow-controlled ventilation in moderate acute respiratory distress syndrome due to COVID-19: an open-label repeated-measures controlled trial

Dessel

Meyer

Morrison

et al. 2022

ICMx

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Background Flow-controlled ventilation (FCV), a novel mode of mechanical ventilation characterised by constant flow during active expiration, may result in more efficient alveolar gas exchange, better lung recruitment and might be useful in limiting ventilator-induced lung injury. However, data regarding FCV in mechanically ventilated patients with acute lung injury or acute respiratory distress syndrome (ARDS) are scarce. Objectives We hypothesised that the use of FCV is feasible and would improve oxygenation in moderate COVID-19 ARDS compared to conventional ventilation. Design Open-label repeated-measures controlled trial. Setting From February to April 2021, patients with moderate COVID-19 ARDS were recruited in a tertiary referral intensive care unit. Patients Patients with moderate ARDS (PaO2/FIO2 ratio 100–200 mmHg, SpO2 88–94% and PaO2 60–80 mmHg) were considered eligible. Exclusion criteria were: extremes of age (< 18 years, > 80 years), obesity (body mass index > 40 kg/m2), prone positioning at the time of intervention, mechanical ventilation for more than 10 days and extracorporeal membrane oxygenation. Eleven patients were recruited. Intervention Participants were ventilated in FCV mode for 30 min, and subsequently in volume-control mode (VCV) for 30 min. Main outcome measures Feasibility of FCV to maintain oxygenation was assessed by the PaO2/FiO2 ratio (mmHg) as a primary outcome parameter. Secondary outcomes included ventilator parameters, PaCO2 and haemodynamic data. All adverse events were recorded. Results FCV was feasible in all patients and no adverse events were observed. There was no difference in the PaO2/FIO2 ratio after 30 min of ventilation in FCV mode (169 mmHg) compared to 30 min of ventilation in VCV mode subsequently (168 mmHg, 95% CI of pseudo-medians (− 10.5, 3.6), p = 0.56). The tidal volumes (p < 0.01) and minute ventilation were lower during FCV (p = 0.01) while PaCO2 was similar at the end of the 30-min ventilation periods (p = 0.31). Mean arterial pressure during FCV was comparable to baseline. Conclusions Thirty minutes of FCV in patients with moderate COVID-19 ARDS receiving neuromuscular blocking agents resulted in similar oxygenation, compared to VCV. FCV was feasible and did not result in adverse events. Trial registration: Clinicaltrials.gov identifier: NCT04894214.

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Section: Discussionmentioning

confidence: 79%

Section: Introductionmentioning

confidence: 99%