Flow chemistry of main group and transition metal complexes

Continuous Flow Synthesis of Group 11 Metal‐NHC Complexes [M(IPr)(OC(H)(CF3)2)] (with M=Cu, Ag and Au)

“…[6] It should come as no surprise that these characteristics have cemented its use in modern-day chemistry including organometallics. [7] Although solids are often men-tioned as the Achilles-heel of flow chemistry, when a wellcontrolled system is built with capable pumps, the use of packed beds or solid supported catalysts can help to make heterogeneous reactions much more efficient and sustainable as well as opening the door to telescoping opportunities. [8] Recently, the prominent fields of N-heterocyclic carbenes and flow chemistry were harmoniously combined to apply the weak-base method in a continuous setup.…”

“…The benefits this entails for reproducibility, selectivity, ease of scale‐up and telescoping are well documented [6] . It should come as no surprise that these characteristics have cemented its use in modern‐day chemistry including organometallics [7] . Although solids are often mentioned as the Achilles‐heel of flow chemistry, when a well‐controlled system is built with capable pumps, the use of packed beds or solid supported catalysts can help to make heterogeneous reactions much more efficient and sustainable as well as opening the door to telescoping opportunities [8]…”