Floating drug delivery systems: A better approach

Chandel, Abhishek; Chauhan, Kapil; Parashar, Bharat; Kumar, Hitesh; Arora, Sonia

doi:10.3329/icpj.v1i5.10283

Cited by 53 publications

(54 citation statements)

References 23 publications

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“…The time for which the tablet remained floating on the surface of medium was determined as floating time. [25][26] …”

Section: Floating Timementioning

confidence: 99%

Untitled

2016

RJLBPCS

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“…The time for which the tablet remained floating on the surface of medium was determined as floating time. [25][26] …”

Section: Floating Timementioning

confidence: 99%

Untitled

2016

RJLBPCS

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“…A few strategies are being utilized for effective plan of a GRDDS to improve the GRT for most extreme assimilation in upper part of gastric system such as floating DDS, low density system (LDS), bioadhesive, superporous hydrogel, and magnetic system. The floating drug delivery is most broadly utilized among these methods [1][2][3]. The float formulation is an efficient approach to extend the residence time in stomach to increase the absorption of less soluble or less stable drugs in digestive system.…”

Section: Introductionmentioning

confidence: 99%

Ranitidine Loaded Biopolymer Floats: Designing, Characterization, and Evaluation

Karim

Shaheen

Mehmood

et al. 2017

Journal of Chemistry

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The float formulation is a strategy to improve the bioavailability of drugs by gastroretentive drug delivery system (GRDDS). A drug delivery model based on swellable and reswellable low density biopolymers has been designed to evaluate its drug release profile using ranitidine (RNT) as a model drug and formulations have been prepared utilizing 3 2 factorial designs. The drug release (DR) data has been subjected to various kinetic models to investigate the DR mechanism. A reduction in rate has been observed by expanding the amounts of PSG and LSG parts, while an expansion has been noted by increasing the concentration of tragacanth (TG) and citric acid (CA) with an increment in floating time. The stearic acid (SA) has been used to decrease the lag time because a decrease in density of system was observed. The kinetic analysis showed that the optimized formulation (S4F3) followed zero-order kinetics and power law was found to be best fitted due to its minimum lag time and maximum floating ability. The resemblance of observed and predicted values indicated the validity of derived equations for evaluating the effect of independent variables while kinetic study demonstrated that the applied models are feasible for evaluating and developing float for RNT.

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“…Gastro retention helps to provide better availability of new products with new therapeutic possibilities and substantial benefits for patients (Chandel et al, 2012). Various approaches that have been reported in the literature for the formulation of gastroretentive systems: mucoadhesion, (Ponchel et al, 1998;Lanerts et al, 1990) flotation, (Deshpande et al1997) sedimentation, (Rednick et al, 1970;Davis et al,1986) expansion (Urguhart et al, 1994;Mamajel et al, 1980) and modified shape systems (Fix et al, 1993;Kedzierewicz et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

Formulation and characterization of gastroretentive drug delivery system of losartan potassium

Jaimini

Tanwar²,

Srivastava

2012

Int Curr Pharm J

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Floating matrix tablets of losartan potassium were developed with an aim to prolong its gastric residence time and increase the bioavailability of drug. Rapid gastrointestinal transit could result in incomplete drug release from the drug delivery system above the absorption zone leading to diminished efficacy of the administered dose. The tablets were prepared by wet granulation technique, using polymers Methocel K15 and Methocel K100 in combination with other standard excipients. Sodium bicarbonate was incorporated as gas generating agent. The effects of sodium bicarbonate and polymers on drug release profile and floating properties were investigated. It was found that viscosity of Methocel K15 and Methocel K100 along with sodium bicarbonate had significant impact on the release and floating properties of the delivery system. The decrease in the release rate was observed with an increase in the viscosity of the polymeric system. Polymer with high viscosity Methocel K100 was shown to be beneficial than low viscosity polymer Methocel K15 in improving the floating properties of gastric floating drug delivery system (GFDDS). The observed difference in the drug release and floating properties of GFDDS could be attributed to the difference in the basic properties of two polymers, Methocel K15 and Methocel K100 due to their water uptake potential and functional group substitution. The release mechanism were explored and described with zero-order, first-order and Korsmeyer-Peppas equations. The drug release profiles and buoyancy of the floating tablets were stable when stored at 40°C/75% RH for 6 months.DOI: http://dx.doi.org/10.3329/icpj.v2i1.12872 International Current Pharmaceutical Journal 2012, 2(1): 11-17

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Floating drug delivery systems: A better approach

Cited by 53 publications

References 23 publications

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Ranitidine Loaded Biopolymer Floats: Designing, Characterization, and Evaluation

Formulation and characterization of gastroretentive drug delivery system of losartan potassium

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