Flixweed vs. Polyethylene Glycol in the Treatment of Childhood Functional Constipation: A Randomized Clinical Trial

Nimrouzi, Majid; Sadeghpour, Omid; Imanieh, Mohammad Hadi; Ardekani, Mohammadreza Shams; Salehi, Alireza; Minaei, Mohamad Bagher; Zarshenas, Mohammad M.

doi:10.5812/ijp.425

Cited by 24 publications

(28 citation statements)

References 20 publications

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“…Among the herbal remedies used, Descurainia sophia is one of the most common herbs used in Traditional Persian Medicine as a neonatal jaundice remedy (28-30). Although we did not find any study about the relationship between D. sophia and jaundice, some research that showed anti-inflammatory and laxative effects of D. sophia (31,32). Thymus vulgaris is another plant used frequently by patients, especially for abdominal pain.…”

Section: Discussionmentioning

confidence: 86%

Use of complementary and alternative medicine among paediatric patients with hepatogastrointestinal diseases

Mosavat¹,

Heydari²,

Hashempur³

et al. 2018

East Mediterr Health J

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Among paediatric medical conditions, chronic gastrointestinal complaints and diseases such as chronic constipation, chronic abdominal pain and failure to thrive, along with patients with chronic hepatic diseases such as cirrhosis and hepatic transplant patients, are also disposed to high prevalence of CAM use (11). Use of CAM in these patients has specific considerations such as potential lower toxic doses and different herb and drug interactions in the absence of normal liver metabolism. These facts emphasize the need for more information on CAM use and associated factors in children with hepatic and gastrointestinal diseases. This study aimed to evaluate the prevalence and type of CAM use in patients attending a paediatric

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Section: Discussionmentioning

confidence: 86%

Use of complementary and alternative medicine among paediatric patients with hepatogastrointestinal diseases

Mosavat¹,

Heydari²,

Hashempur³

et al. 2018

East Mediterr Health J

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“…for children with chronic FC and IBS, especially when standard treatment has failed (57). Further studies will be needed to understand the complex pathogenic mechanisms of FGIDs.…”

Section: Discussionmentioning

confidence: 99%

Allergy in Children with Functional Constipation and Irritable Bowel Syndrome

et al. 2016

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Context: Functional constipation (FC) and irritable bowel syndrome (IBS) represent very common pediatric functional gastrointestinal disorders (FGIDs). Controversial results have suggested a potential role of food allergy as a trigger of functional bowel symptoms. Evidence Acquisition: This review summarizes the literature regarding the role of allergic diseases in children with FC and IBS and discusses the hypothesis of the pathogenesis of constipation due to cow's milk protein allergy (CMPA). We searched systematic reviews, guidelines, or original data in PubMed, MEDLINE, and the Cochrane central register of controlled trials. Results: The pathogenesis of FGIDs remains elusive and is likely multifactorial. Among these factors, adverse reactions to food may play a pathogenic role. Some features, such as abnormal bowel motility, visceral hypersensitivity, and changes in mucus composition caused by inflammation of the gastrointestinal wall, have been found both in IBS or FC and in food allergy. Since 1978, an increasing number of reports have suggested a relationship between CMPA and FC. Two randomized controlled studies conducted in children showed that CMPA may induce chronic FC; one study indicated that fermentable oligosaccharide, disaccharide, and monosaccharide polyols (FODMAP) foods may play a role in triggering IBS. Conclusions: Food allergy in children with chronic constipation should be identified using an oral food challenge after being on a diet free of cow's milk. A diet low in FODMAPs might also be recommended for children with IBS. This approach could be suggested for children with chronic FC and IBS, especially when they do not respond to standard treatment. However, it should also be considered that a minority of patients with FC or IBS could respond to an elimination diet. Further studies are needed to understand the complex pathogenic mechanisms of FGIDs; they also might be helpful to recognize markers for identifying children with IBS and FC caused by foods and to improve their management.

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“…[ 14 ]. A recent randomized clinical trial showed that the oral administration of D. sophia seeds relieved chronic functional constipation in children which was statistically significant [ 15 ]. Some research groups including us have identified various types of secondary metabolites from D. sophia seeds.…”

Section: Introductionmentioning

confidence: 99%

Effect of an ethanol extract of Descurainia sophia seeds on Phase I and II drug metabolizing enzymes and P-glycoprotein activity in vitro

Kim

Lee

et al. 2015

BMC Complement Altern Med

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BackgroundDescurainia sophia seeds have a variety of pharmacological functions and been widely used in traditional folk medicine. However, their effects on human drug metabolizing enzyme (DME) activities have not been elucidated. The present study investigated the inhibitory effects of an ethanol extract of D. sophia seeds (EEDS) on human Phase I/II (DMEs) and P-glycoprotein (p-gp) in vitro.MethodsThe enzyme activities of human Phase I (cytochrome P450s, CYPs), Phase II (uridine diphosphate glucuronosyltransferases, UGTs) DMEs, and the drug transporter P-gp were determined in the presence of various concentrations of EEDS using commercially available luminogenic assay systems. The mode of enzyme inhibition and the inhibitory constant (Ki) value of EEDS were graphically determined with Lineweaver-Burk double reciprocal plots and secondary plots, respectively.ResultsThe enzyme activity assays showed that EEDS moderately inhibited the CYP1A2, CYP2C9, and CYP2C19 isoforms with half maximal inhibitory concentrations (IC50) of 47.3, 25.8, and 38.7 μg/mL, respectively. Graphical analyses with Lineweaver-Burk double reciprocal plots and secondary plots indicated that EEDS competitively inhibited CYP2C9 with a Ki value of 19.8 μg/mL; however, it inhibited CYP2C9 and CYP2C19 in a mixed mode with Ki values of 5.2, and 11.9 μg/mL, respectively. Other Phase I (CYP2C8, CYP2D6, and CYP3A4) and Phase II (UGT1A1 and UGT2B7) enzymes as well as P-gp were weakly or negligibly affected by EEDS with concentrations up to 500 μg/mL.ConclusionsEEDS is a selective inhibitor of CYP1A2, CYP2C9, and CYP2C19 with moderate enzymatic inhibition. Clinically, full consideration should be given to a potential toxic adverse effect from a herb-drug interaction when drugs that are particularly susceptible to CYP1A2, CYP2C9, or CYP2C19-mediated metabolism are taken together with EEDS. Characterization of metabolic profiles of specific herbal drugs could help consumers and medical specialists to use them safely as a complementary and alternative medicine.

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Flixweed vs. Polyethylene Glycol in the Treatment of Childhood Functional Constipation: A Randomized Clinical Trial

Cited by 24 publications

References 20 publications

Use of complementary and alternative medicine among paediatric patients with hepatogastrointestinal diseases

Use of complementary and alternative medicine among paediatric patients with hepatogastrointestinal diseases

Allergy in Children with Functional Constipation and Irritable Bowel Syndrome

Effect of an ethanol extract of Descurainia sophia seeds on Phase I and II drug metabolizing enzymes and P-glycoprotein activity in vitro

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