Flight reactions to nitric oxide in the inferior colliculus of rats depend on NMDA receptor activation

Moreira, Fabrício de Araújo; Molchanov, M.L.; Guimarães, Francisco Silveira

doi:10.1016/s0091-3057(03)00186-2

Cited by 14 publications

(3 citation statements)

References 38 publications

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“…These findings are consistent with some previous studies in teleosts (Villani and Guarnieri, 1995), but not with others (Brüning et al, 1995). Studies in land vertebrates also show that these structures are nitrergic (Smeets et al, 1997;Gonzalez et al, 2002;Lopez and Gonzalez, 2002;de Araujo Moreira et al, 2003). The presence of labeled cells in the torus semicircularis and nucleus isthmi could involve a role of NO in the modulation of sensory signals (Holmqvist et al, 1994;Ando et al, 2004).…”

Section: Mesencephalonsupporting

confidence: 92%

Distribution of NADPH-diaphorase and nitric oxide synthase reactivity in the central nervous system of the goldfish (Carassius auratus)

Giráldez-Pérez

Gaytán

Ruano

et al. 2008

Journal of Chemical Neuroanatomy

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Section: Mesencephalonsupporting

confidence: 92%

Distribution of NADPH-diaphorase and nitric oxide synthase reactivity in the central nervous system of the goldfish (Carassius auratus)

Giráldez-Pérez

Gaytán

Ruano

et al. 2008

Journal of Chemical Neuroanatomy

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“…Other studies using intra-mesencephalic pharmacological approaches have shown that the NMDA receptor can mediate fear-related defensive responses evoked by local microinjection of the NO donor SIN-1, an active metabolite of molsidomine. For example, the blockade of NMDA receptors in both periaqueductal grey (PAG) matter and the inferior colliculus was able to impair the jumping reaction and locomotor activity (distance moved), respectively, induced by SIN-1 microinjected in these same midbrain tectum structures (de Araújo Moreira et al, 2003; Moreira et al, 2004). In fact, the NMDA receptor seems to influence the nitrergic effect on mesencephalic defensive behaviours.…”

Section: Introductionmentioning

confidence: 99%

The Nitric Oxide Donor SIN-1-Produced Panic-Like Behaviour And Fear-Induced Antinociception Are Modulated By NMDA Receptors In The Anterior Hypothalamus

Falconi‐Sobrinho

Coimbra

2018

J Psychopharmacol

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“…16,17 And, centrally administered SIN-1-produced flight reactions in rats and panic-like behavior in mice depended on NMDA receptor activation. 32,33 In this study, the SIN-1-induced ICI reduction was attenuated by icv-pretreated MK-801 (10 and 30 nmol/rat), an antagonist of NMDA receptors in continuous cystometry. On the other hand, an AMPA receptor antagonist DNQX (3 nmol/rat) showed no effect on the SIN-1-induced response in continuous cystometry.…”

Section: Discussionmentioning

confidence: 63%

Brain nitric oxide induces facilitation of the micturition reflex through brain glutamatergic receptors in rats

Ono

Shimizu

Zou

et al. 2020

Neurourology and Urodynamics

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Aim Brain nitric oxide (NO) have been reported in regulation of the sympatho‐adrenomedullary system, which can affect voiding and storage functions. Therefore, we investigated effects of intracerebroventricularly (icv) administered 3‐(4‐morpholinyl)sydnonimine, hydrochloride (SIN‐1) (NO donor) on the micturition reflex, focusing on their dependence on the sympatho‐adrenomedullary system and on brain N‐methyl‐D‐aspartate (NMDA) and α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazole propionate (AMPA) receptors in urethane‐anesthetized (0.8 g/kg, ip) male Wistar rats. Methods Plasma noradrenaline and adrenaline were measured just before and 5 minutes after SIN‐1 administration. Evaluation of urodynamic parameters was started 1 hour before SIN‐1 administration or intracerebroventricular pretreatment with other drugs. Results SIN‐1 (100 and 250 µg/animal) elevated plasma adrenaline and reduced intercontraction interval ([ICI] values; 110.5% [SIN‐1, 0 µg] and 54.9% [SIN‐1, 250 µg] during 15 minutes after SIN‐1 administration [P < .05; η2 = 0.59]) without affecting plasma noradrenaline or maximal voiding pressure. SIN‐1 (250 µg/animal) reduced single‐voided volume and bladder capacity without affecting post‐voiding residual volume. The SIN‐1 (250 µg/animal)‐induced adrenaline elevation and ICI reduction were attenuated by 2‐(4‐carboxyphenyl)‐4,4,5,5‐tetramethylimidazoline‐1‐oxyl‐3‐oxide, sodium salt (carboxy‐PTIO) (NO scavenger, icv) (ICI values; 44.7% [vehicle + SIN‐1] and 77.5% [carboxy‐PTIO + SIN‐1] during 15 minutes after SIN‐1 administration [P < .05; η2 = 0.51]). Acute bilateral adrenalectomy abolished SIN‐1‐induced adrenaline elevation, while showed no effect on the SIN‐1‐induced ICI reduction. The ICI reduction was attenuated by MK‐801 (NMDA receptor antagonist, icv) (ICI values; 47.0% [vehicle + SIN‐1] and 87.6% [MK‐801 + SIN‐1] during 15 minutes after SIN‐1 administration [P < .05; η2 = 0.61]), but not by DNQX (AMPA receptor antagonist, icv). Conclusion Brain NO is involved in facilitation of the rat micturition reflex through brain NMDA receptors, independently of the sympatho‐adrenomedullary outflow modulation.

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Flight reactions to nitric oxide in the inferior colliculus of rats depend on NMDA receptor activation

Cited by 14 publications

References 38 publications

Distribution of NADPH-diaphorase and nitric oxide synthase reactivity in the central nervous system of the goldfish (Carassius auratus)

Distribution of NADPH-diaphorase and nitric oxide synthase reactivity in the central nervous system of the goldfish (Carassius auratus)

The Nitric Oxide Donor SIN-1-Produced Panic-Like Behaviour And Fear-Induced Antinociception Are Modulated By NMDA Receptors In The Anterior Hypothalamus

Brain nitric oxide induces facilitation of the micturition reflex through brain glutamatergic receptors in rats

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