Objective. Despite the increasing interest in knee cartilage volume as an outcome measure in studies of osteoarthritis (OA), it is unclear what components of knee cartilage will be most useful as markers of structural change in the tibiofemoral joint. This study was undertaken to longitudinally compare changes in femoral and tibial cartilage volume in patients with OA.Methods. One hundred seventeen patients with knee OA (58.1% women; mean ؎ SD age 63.7 ؎ 10.2 years) were examined. Femoral and tibial cartilage volumes (medial and lateral tibiofemoral joints) were determined from T1-weighted fat-saturated magnetic resonance images of the knee from coronal views.Results. The study population was followed up for a mean ؎ SD of 1.9 ؎ 0.2 years. In the medial tibiofemoral joint, the mean ؎ SD loss of cartilage was 0.15 ؎ 0.30 ml/year for femoral cartilage and 0.10 ؎ 0.25 ml/year for tibial cartilage. In the lateral tibiofemoral joint, the average loss was 0.15 ؎ 0.22 and 0.12 ؎ 0.16 ml/year for femoral and tibial cartilage, respectively. There was a significant correlation between the degree of loss of tibial cartilage and the degree of loss of femoral cartilage, in both tibiofemoral joints (r ؍ 0.81, P < 0.001 at the medial tibiofemoral joint; r ؍ 0.71, P < 0.001 at the lateral tibiofemoral joint).Conclusion. Longitudinal changes in tibial cartilage and those in femoral cartilage are strongly related to one another. This suggests that in tibiofemoral disease, measuring tibial cartilage alone may be adequate, given the facts that measurements of the total femoral cartilage are less reproducible and there are difficulties inherent in identifying the most appropriate component of femoral cartilage to measure.There has been increasing interest in the use of magnetic resonance imaging (MRI) in the measurement of knee cartilage volume as a possible outcome measure in arthritis (1-3). MRI has been shown to provide a valid quantification of cartilage volume as compared with findings of anatomic dissection. The method is reproducible, with coefficients of variation (CVs) of ϳ2% (2-4). This technique has been used to explore factors that influence knee cartilage in healthy adults and children (3,4).One problem is that with most techniques currently in use to measure knee cartilage volume, manual manipulation has to be performed to varying degrees, and the techniques are consequently quite timeconsuming and their use is limited to relatively few institutions (1-3). One potential approach is to attempt to limit the components of knee cartilage being measured and still retain cartilage measures that are a valid gauge of the state of joint cartilage. We have previously shown a strong correlation between femoral cartilage volume and tibial cartilage volume measured in both the medial and lateral tibiofemoral compartments of the knee in healthy subjects and those with osteoarthritis (OA) (5). Since measurements of the total femoral cartilage are less reproducible and there are difficulties in identifying the most appropriate com...