Flexible substrate-based thermo-responsive valve applied in electromagnetically powered drug delivery system

Yi, Ying; Huang, Ruining; Li, Changping

doi:10.1007/s10853-018-3083-9

Cited by 11 publications

(8 citation statements)

References 38 publications

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“…MEMS drug delivery systems use microvalves to channel/regulate the drug flow into the diseased location [150]. Thermoresponsive hydrogels have been often used to form smart microvalves in them [84,86,[151][152][153][154][155][156]. A study reported an implantable drug delivery device that was fabricated to integrate PNIPAM microvalves with a wireless resonant heater and a drug reservoir [84].…”

Section: Implantable Drug Delivery Systemsmentioning

confidence: 99%

MEMS actuators for biomedical applications: a review

Ghazali

Hasan

Rehman

et al. 2020

J. Micromech. Microeng.

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Micro-electromechanical-system (MEMS) based actuators, which transduce certain domains of energy into mechanical movements in the microscopic scale, are increasingly contributing to the areas of biomedical engineering and healthcare applications. They are enabling new functionalities in biomedical devices through their unique miniaturized features. An effective selection of a particular actuator, among a wide range of actuator types available in the MEMS field, needs to be made through the assessment of many factors involved in both the actuator itself and the target application. This paper presents an overview of the state-of-the-art MEMS actuators that have been developed for biomedical applications. The actuation methods, working principle, and imperative features of these actuators are discussed along with their specific applications. An emphasis of this review is placed on temperature-responsive, electromagnetic, piezoelectric, and fluid-driven actuators towards various application areas including lab-on-a-chip, drug delivery systems, cardiac devices and surgical tools. It also highlights the key issues of MEMS actuators in light of biomedical applications.

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Section: Implantable Drug Delivery Systemsmentioning

confidence: 99%

MEMS actuators for biomedical applications: a review

Ghazali

Hasan

Rehman

et al. 2020

J. Micromech. Microeng.

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“…The resultant recoil force propels the microrobot that is generally fabricated in the form of a tube containing the catalytic material on its inner surface [98,99]. The tubular design facilitates the accumulation and accelerated expulsion of the bubbles [100][101][102]. As the internal gas pressure increases with the gas accumulation in the tube, the bubbles are ejected through the opening of the tube [103,104].…”

Section: Chemical Reaction-based Actuationmentioning

confidence: 99%

Targeted drug delivery technology using untethered microrobots: a review

Jang

Jeong

Song

et al. 2019

J. Micromech. Microeng.

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Targeted drug delivery is a promising application of microrobots owing to the capability of the microrobots to access nearly every region of the human body through the circulatory system. Research on microrobots over the past few decades has enabled substantial advances in the design of both the untethered microrobots swimming in a biofluid and the related mechanisms to carry and release therapeutic agents in a controlled manner. This paper presents a comprehensive review of the technological state of the art in untethered microrobots for targeted drug delivery applications. First, the in vivo microrobot locomotion techniques are discussed with respect of the different types of actuation energy sources such as magnetic fields, motile microorganisms, acoustic waves, and chemical reaction, outlining the respective advantages and major limitations. Subsequently, recent progress in various technologies of microrobot-driven targeted drug delivery is surveyed deliberating on the corresponding drug manipulation mechanisms: magnetically driven, motile microorganisms-driven, acoustic-aided, and stimuli-responsive hydrogels-aided. Although most studies on microrobot-driven targeted drug delivery were carried out in vitro, few among them successfully demonstrated in vivo operations in living animals. In the concluding section, current challenges and future perspectives of the microrobot-driven targeted drug delivery technology are discussed.

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“…In contrast to passive DDS, active delivery systems allow for adjusting the released amount of the drug through external physical or chemical stimuli. These include ultrasound, light, electric, and/or magnetic fields [ 17 , 18 , 19 , 20 ], mechanical forces, temperature, or pH [ 10 , 12 , 21 ]. As an example, drug delivery devices (DDDs) remotely activated by a magnetic field have been recently reported [ 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

Photomechanical Polymer Nanocomposites for Drug Delivery Devices

et al. 2021

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We demonstrate a novel structure based on smart carbon nanocomposites intended for fabricating laser-triggered drug delivery devices (DDDs). The performance of the devices relies on nanocomposites’ photothermal effects that are based on polydimethylsiloxane (PDMS) with carbon nanoparticles (CNPs). Upon evaluating the main features of the nanocomposites through physicochemical and photomechanical characterizations, we identified the main photomechanical features to be considered for selecting a nanocomposite for the DDDs. The capabilities of the PDMS/CNPs prototypes for drug delivery were tested using rhodamine-B (Rh-B) as a marker solution, allowing for visualizing and quantifying the release of the marker contained within the device. Our results showed that the DDDs readily expel the Rh-B from the reservoir upon laser irradiation and the amount of released Rh-B depends on the exposure time. Additionally, we identified two main Rh-B release mechanisms, the first one is based on the device elastic deformation and the second one is based on bubble generation and its expansion into the device. Both mechanisms were further elucidated through numerical simulations and compared with the experimental results. These promising results demonstrate that an inexpensive nanocomposite such as PDMS/CNPs can serve as a foundation for novel DDDs with spatial and temporal release control through laser irradiation.

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Flexible substrate-based thermo-responsive valve applied in electromagnetically powered drug delivery system

Cited by 11 publications

References 38 publications

MEMS actuators for biomedical applications: a review

MEMS actuators for biomedical applications: a review

Targeted drug delivery technology using untethered microrobots: a review

Photomechanical Polymer Nanocomposites for Drug Delivery Devices

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