Flexible Polyimide Micropump Fabricated Using Hot Embossing

Komatsuzaki, Hiroki; Suzuki, Kenta; Liu, Yingwei; Kosugi, Tatsuya; Ikoma, Ryuta; Youn, Sung-Won; Takahashi, Masaharu; Maeda, Ryutaro; Nishioka, Yasushiro

doi:10.7567/jjap.50.06gm09

Cited by 20 publications

(10 citation statements)

References 32 publications

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“…The geometrical parameters in the nozzle‐diffuser such as the divergence angle ( ϴ = 10°) and throat width ratio ( w 2 / w 1 = 3.8) were considered to minimize the back draw flow and maximize the forward flow (Figure 3b). [ 32 ] Furthermore, the inlet sides of each nozzle‐diffuser model were designed with a rounded shape to reduce the forward flow resistance (Figure 3b, inset). Instead of using the conventional wafer‐based lithography, an additive 3D printing technique was adopted to print a positive master mold to demonstrate the concept of realizing a low‐cost and scalable microfluidic device (Figure 3c).…”

Section: Resultsmentioning

confidence: 99%

A Printable Thin Film‐Based Digital Peristaltic Sticker‐Pump for a Simple and Robust Integration into Microfluidics

Koirala

Shrestha

Lim

et al. 2021

Adv Materials Technologies

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A micropump is pivotal for routing and multiplexing fluids in microfluidic channels, especially for point‐of‐care diagnostic devices. In this regard, a simple and easily mountable micropump‐platform needs to be developed to expand the applications of microfluidic devices. Here, the sticker type‐peristaltic pump, called “sticker‐pump,” is developed by incorporating an array of biocompatible polymeric bimorph actuators. The sticker‐pump can be activated via digital input sequence to control the flow rate in response to the operating voltage and switching speed. Furthermore, the programmed digital sequence demonstrates the generation of pulsatile and continuous flows without any back pressure. The sticker‐pump is further studied through a systematic characterization to validate the working mechanism of one sticker‐pump (1‐bit) and the flow rates (3.77–36.90 µL min−1) attained by the combination of three sticker‐pumps (3‐bit) on microfluidics. Since the sticker‐pump is all solution‐processed, an inexpensive sticker‐pump can be manufactured by scalable printing technologies.

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Section: Resultsmentioning

confidence: 99%

A Printable Thin Film‐Based Digital Peristaltic Sticker‐Pump for a Simple and Robust Integration into Microfluidics

Koirala

Shrestha

Lim

et al. 2021

Adv Materials Technologies

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“…PI has superior heat resistance, mechanical strength, and chemical stability. Therefore, PI is expected to withstand the high temperature of sterilization processing, and it is possible to transfer microstructures by hot embossing suitable for MEMS fabrication processes [4]. However, conventional PI is not transparent with a thick tan color, which makes it difficult to observe cultured biological cells on PI sheets.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of transparent polyimide film as biological cell culture sheet with microstructures for biomedical engineering

Maenosono

Saito

Nishioka

2013

2013 International Conference on Optical MEMS and Nanophotonics (OMN)

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Potentials of the transparent polyimide (PI) substrate were investigated for a possible biological cell culture sheet. Stromal marrow cells (OP9) were used to test the cell culture characteristics, and the OP9 cell culture was compared on three kinds of polymer films of transparent PI, parylene (PA), and polyetheretherketone (PEEK). Microtrenches with the width of 5 m and the depth of 5 m were fabricated using hot embossing technique on these films. The cultured cell of OP9 was observed on the transparent PI sheet and PA sheet, but not on PEEK sheet. The culture of OP9 cells were easily observed on the transparent PI sheet using an optical microscope.

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“…42) Therefore, a power source with an area of cm 2 order, equivalent to the area of a current cardiac pacemaker, must exhibit a power density of 10 µW=cm 2 in an aqueous an AA solution with an AA concentration between 23 and 85 µM. Mogi et al 43) reported the fabrication and characterization of a miniaturized AAFC with a microchannel fabricated on a PI substrate using thermal nanoimprinting techniques [44][45][46][47] and MEMS technologies. However, they utilized porous carbon electrodes deposited on a flexible PI film, and these electrodes cracked after repeated bending of the BFC.…”

Section: Introductionmentioning

confidence: 99%

Miniaturized ascorbic acid fuel cells with flexible electrodes made of graphene-coated carbon fiber cloth

Hoshi

Muramatsu²,

Sumi³

et al. 2016

Jpn. J. Appl. Phys.

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Ascorbic acid (AA) is a biologically friendly compound and exists in many products such as sports drinks, fruit, and even in human blood. Thus, a miniaturized and flexible ascorbic acid fuel cell (AAFC) is expected be a power source for portable or implantable electric devices. In this study, we fabricated an AAFC with anode and cathode dimensions of 3 × 10 mm2 made of a graphene-coated carbon fiber cloth (GCFC) and found that GCFC electrodes significantly improve the power generated by the AAFC. This is because the GCFC has more than two times the effective surface area of a conventional carbon fiber cloth and it can contain more enzymes. The power density of the AAFC in a phosphate buffer solution containing 100 mM AA at room temperature was 34.1 µW/cm2 at 0.46 V. Technical issues in applying the AAFC to portable devices are also discussed.

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Flexible Polyimide Micropump Fabricated Using Hot Embossing

Cited by 20 publications

References 32 publications

A Printable Thin Film‐Based Digital Peristaltic Sticker‐Pump for a Simple and Robust Integration into Microfluidics

A Printable Thin Film‐Based Digital Peristaltic Sticker‐Pump for a Simple and Robust Integration into Microfluidics

Evaluation of transparent polyimide film as biological cell culture sheet with microstructures for biomedical engineering

Miniaturized ascorbic acid fuel cells with flexible electrodes made of graphene-coated carbon fiber cloth

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