Flexible photothermal biopaper comprising Cu2+-doped ultralong hydroxyapatite nanowires and black phosphorus nanosheets for accelerated healing of infected wound

Zeng, Junkai; Geng, Xiangwu; Tang, Yifan; Xiong, Zhi‐Chao; Zhu, Ying‐Jie; Chen, Xiongsheng

doi:10.1016/j.cej.2022.135347

Cited by 22 publications

(13 citation statements)

References 60 publications

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“…35 The primary mechanism of Cu 2+ in modulating wound healing was mostly dependent on upregulating vascular endothelial growth factor and integrin, stimulating the multiplication of human umbilical vein endothelial cells, inducing collagen deposition, and increasing copper-dependent enzymes. 36,37 The human umbilical vein endothelial cells (HUVEC) showed great effects in terms of inflammation and wound healing. 38,39 Herein, a wound-scratch assay was performed to appraise the impact of MOF@Cu 2+ on HUVEC migration.…”

Section: In Vitro Biocompatibility and Cell Migration Assays Of Mof@c...mentioning

confidence: 99%

Copper(ii)-infused porphyrin MOF: maximum scavenging GSH for enhanced photodynamic disruption of bacterial biofilm

Zhang,

Li,

Liu

et al. 2024

J. Mater. Chem. B

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Section: In Vitro Biocompatibility and Cell Migration Assays Of Mof@c...mentioning

confidence: 99%

Copper(ii)-infused porphyrin MOF: maximum scavenging GSH for enhanced photodynamic disruption of bacterial biofilm

Zhang,

Li,

Liu

et al. 2024

J. Mater. Chem. B

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“…Immunofluorescence staining was conducted as previously described. [40] CD206 was selected as a marker of M2 macrophages, while iNOS was selected as a marker of M1 macrophages. For flow cytometry, CD86-positive and CD206-negative cells were recognized as M1 macrophages, while CD206-positive and CD86-negative cells were recognized as M2 macrophages.…”

Section: Characterization Of Mex and Meximentioning

confidence: 99%

Engineering of M2 Macrophages‐Derived Exosomes via Click Chemistry for Spinal Cord Injury Repair

Zeng

Sun

et al. 2023

Adv Healthcare Materials

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Spinal cord injury (SCI) is one of the most common causes of death and disability. The effective modulation of complicated microenvironment, regeneration of injured spinal cord tissue, and the functional recovery after SCI are still clinical challenges. Recently, macrophages‐derived exosomes have shown great potential for various diseases due to their inflammation‐targeting property. However, further modifications are needed to endow exosomes with the neural regenerative potential for SCI recovery. In the current study, a novel nanoagent (MEXI) is designed for SCI treatment by conjugating bioactive IKVAV peptides to the surface of M2 macrophages‐derived exosomes via an easy and rapid click chemistry method. In vitro, MEXI inhibits the inflammation by reprograming macrophages and promotes neuronal differentiation of neural stem cells. In vivo, engineered exosomes target the injured site of the spinal cord after tail vein injection. Furthermore, histological analysis reveals that MEXI improves motor functional recovery of SCI mice by reducing infiltration of macrophages, downregulating pro‐inflammatory factors, and improving the regeneration of injured nervous tissues. Taken together, this study provides strong evidence for the significance of MEXI in SCI recovery.

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“…In addition to the ion-induced antibacterial effect, photothermal therapy (PTT) has recently been utilized to kill bacteria via physical heating. 30,118,119 In one case, a multifunctional composite hydrogel combined Cu-doped bioceramics with polydopamine (PDA) was designed for infectious skin wound healing. 120 In this system, the photothermal heating effect of both PDA and Cu ions showed high efficiency and long-term inhibition of methicillin-resistant Escherichia coli and Staphylococcus aureus.…”

Section: Anti-infection Functionmentioning

confidence: 99%

Bioceramic materials with ion‐mediated multifunctionality for wound healing

Wang

Tang

2022

Smart Medicine

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Regeneration of both anatomic and functional integrity of the skin tissues after injury represents a huge challenge considering the sophisticated healing process and variability of specific wounds. In the past decades, numerous efforts have been made to construct bioceramic‐based wound dressing materials with ion‐mediated multifunctionality for facilitating the healing process. In this review, the state‐of‐the‐art progress on bioceramic materials with ion‐mediated bioactivity for wound healing is summarized. Followed by a brief discussion on the bioceramic materials with ion‐mediated biological activities, the emerging bioceramic‐based materials are highlighted for wound healing applications owing to their ion‐mediated bioactivities, including anti‐infection function, angiogenic activity, improved skin appendage regeneration, antitumor effect, and so on. Finally, concluding remarks and future perspectives of bioceramic‐based wound dressing materials for clinical practice are briefly discussed.

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Flexible photothermal biopaper comprising Cu2+-doped ultralong hydroxyapatite nanowires and black phosphorus nanosheets for accelerated healing of infected wound

Cited by 22 publications

References 60 publications

Copper(ii)-infused porphyrin MOF: maximum scavenging GSH for enhanced photodynamic disruption of bacterial biofilm

Copper(ii)-infused porphyrin MOF: maximum scavenging GSH for enhanced photodynamic disruption of bacterial biofilm

Engineering of M2 Macrophages‐Derived Exosomes via Click Chemistry for Spinal Cord Injury Repair

Bioceramic materials with ion‐mediated multifunctionality for wound healing

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