Bioceramic materials with ion‐mediated multifunctionality for wound healing

Abstract

Regeneration of both anatomic and functional integrity of the skin tissues after injury represents a huge challenge considering the sophisticated healing process and variability of specific wounds. In the past decades, numerous efforts have been made to construct bioceramic‐based wound dressing materials with ion‐mediated multifunctionality for facilitating the healing process. In this review, the state‐of‐the‐art progress on bioceramic materials with ion‐mediated bioactivity for wound healing is summarized. Followed by a brief discussion on the bioceramic materials with ion‐mediated biological activities, the emerging bioceramic‐based materials are highlighted for wound healing applications owing to their ion‐mediated bioactivities, including anti‐infection function, angiogenic activity, improved skin appendage regeneration, antitumor effect, and so on. Finally, concluding remarks and future perspectives of bioceramic‐based wound dressing materials for clinical practice are briefly discussed.

A 0D-2D Heterojunction Bismuth Molybdate-Anchored Multifunctional Hydrogel for Highly Efficient Eradication of Drug-Resistant Bacteria

“…Due to the presence of excess ROS, MMPs, which are responsible for extracellular matrix (ECM) homeostasis and re-epithelialization, have elevated expression levels in bacteria-infected wound conditions. Therefore, the regulation of MMP levels through the removal of excess ROS from the ECM plays a crucial role in wound healing. , To verify the effect of ROS scavenging by CPTB@pMBO hydrogels on ECM remodeling, we measured the relative mRNA expression of MMP-2 and MMP-9 by quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR). After 3 days, the relative mRNA expression of MMP-2 and MMP-9 in the CPTB@pMBO group decreased by approximately 73.2% and 44.8%, respectively (Figure b).…”

Bacteriosynthetic Degradable Tranexamic Acid‐Functionalized Short Fibers for Inhibiting Invisible Hemorrhage

“…These different forms of short nanofibers could be widely used in different shapes of trauma for hemostasis. [ 17 ] The chemical compositions of the short fibers are the same regardless of the forms, we have only chosen a spongy form that is commonly used in the hemostatic materials area for further evaluation.…”

Near-IR-Regulated Composite Hydrogel with Real-Time Infection Monitoring and a Combined Antibacterial Effect for Efficient Wound Management

“…Skin, which serves as the largest protective barrier of the human body, is easily damaged by accidents, surgery, and diseases and forms wounds. , Skin wounds greatly reduce the quality of a patient’s life and even threaten the health of humans. Therefore, wound management, especially for infected wounds, has attracted more and more attention in clinic. − The ideal wound management strategy should have the following characteristics: (1) real-time monitoring of the infection status; (2) an efficient antibacterial effect; (3) a suitable platform that integrates real-time-monitoring ability and efficient antibacterial performance. Real-time monitoring of infected wounds contributes to adjustment of the therapeutic schedule and avoids damage to normal tissues caused by excessive treatment.…”