Flexible and disposable gold nanoparticles-N-doped carbon-modified electrochemical sensor for simultaneous detection of dopamine and uric acid

Abstract

Catalytic and electrocatalytic applications of supported metal nanoparticles are hindered due to an aggregation of metal nanoparticles and catalytic leaching under harsh operations. Hence, stable and leaching free catalysts with high surface area are extremely desirable but also challenging. Here we report a gold nanoparticles-hosted mesoporous nitrogen doped carbon matrix, which is prepared using bovine serum albumin (BSA) through calcination. BSA plays three roles in this process as a reducing agent, capping agent and carbon precursor, hence the protocol exhibits economic and sustainable. Gold nanoparticles at N-doped BSA carbon (AuNPs@NBSAC)-modified three-electrode strip-based flexible sensor system has been developed, which displayed effective, sensitive and selective for simultaneous detection of uric acid (UA) and dopamine (DA). The AuNPs@NBSAC-modified sensor showed an excellent response toward DA with a linear response throughout the concentration range from 1 to 50 μM and a detection limit of 0.05 μM. It also exhibited an excellent response toward UA, with a wide detection range from 5 to 200 μM as well as a detection limit of 0.1 μM. The findings suggest that the AuNPs@NBSAC nanohybrid reveals promising applications and can be considered as potential electrode materials for development of electrochemical biosensors.

New Insight into the Mechanism of Simultaneous Determination of Ascorbic Acid, Dopamine, and Uric Acid with Graphene Encapsulated CoFe Alloys Electrochemical Sensor

“…Additionally, it can be seen from Table 1 that the detection ranges of CoFe@G/GCE for AA, DA, and UA are comparable to most of the previous work, and shows lower detection limit than other biosensors such as noble metals like Au, [ 54 ] rare earth metals like Tm, [ 55 ] and other carbon‐based sensors. [ 56–58 ] Thus, the new composite material CoFe@G can be a potential candidate for simultaneous detection of AA, DA, and UA.…”

Palladium nanoparticles/wool keratin-assisted carbon composite-modified flexible and disposable electrochemical solid-state pH sensor

“…[10] The in-situ synthesized PdNPs play an essential role in the carbonization process, in which PdNPs showed a catalytic effect in pyrolysis and CO 2 emission to acquire aromatized carbon structure. [11] WK was the best precursor for the synthesis of the N-doped carbon skeleton with the π-π arrangement, which mimics the A-B type polymeric structure; hence, highly susceptible to H + ions. A series of materials were prepared by temperature variation and used for the fabrication of different strip-based solid-state pH sensors.…”

“…Here, the in-situ prepared PdNPs of the composite mass catalyzed and accelerated the emission of carbon and nitrogen oxides; thus, resulting in the highly 028201-3 porous and aromatized carbon structure. [11] The surface morphology of PdNPs was investigated by high-resolution TEM (HR-TEM) analysis. Figures 2(a…”

Holey MoS2-based electrochemical sensors for simultaneous dopamine and uric acid detection

“…Many studies have been reported for detecting DA and UA in recent years. Metal nanoparticles, 6–8 conducting polymers, 9–11 carbon 12,13 and MXene 14 materials have been used to detect DA and UA electrochemically.…”