Flexible Amoxicillin-Grafted Bacterial Cellulose Sponges for Wound Dressing: In Vitro and in Vivo Evaluation

Ye, Shan; Jiang, Lei; Wu, Jimin; Chen, Su; Huang, Chaobo; Liu, Xiufeng; Shao, Wei

doi:10.1021/acsami.7b16680

Cited by 198 publications

(97 citation statements)

References 31 publications

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“…43 PCL ( Figure 3E) showed a strong characteristic band at 1,734 cm −1 corresponding to C=O stretching and two bands at 2,859 and 2,929 cm −1 due to −CH 2 group stretching. 45 The FTIR spectra of FLS ( Figure 3F) exhibited absorbance bands at 1,150, 1,052, and 1,734 cm −1 , which were assigned to the characteristic bands of C−O−C in mupirocin, the C−C skeleton, and C=O in PCL, respectively. This indicates that mupirocin was successfully grafted onto PCL.…”

Section: Ftirmentioning

confidence: 98%

Electrospun PCL/mupirocin and chitosan/lidocaine hydrochloride multifunctional double layer nanofibrous scaffolds for wound dressing applications

Li¹,

Wang²,

Yang³

et al. 2018

IJN

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BackgroundAn ideal wound dressing should exhibit good biocompatibility, minimize pain and infection, absorb excess exudates, and maintain a moist environment. However, few clinical products meet all these needs. Therefore, the aim of this study was to fabricate a multifunctional double layer nanofibrous scaffolds (DLS) as a potential material for wound dressing.Materials and methodsThe scaffold was formed from mupirocin and lidocaine hydrochloride homogeneously incorporated into polycaprolactone as the first layer of scaffolds and chitosan as the second layer of scaffolds nanofibers through electrospinning. The fabricated nanofibrous scaffolds were characterized by scanning electron microscopy, Fourier transform infrared spectroscopy, thermogravimetric analysis, differential scanning calorimetry, and measurement of swelling ratio, contact angle, drug release, and mechanical properties. Furthermore, antibacterial assessment, live/dead cell assays, and MTT assays were used to investigate the antibacterial activity and cytotoxicity of the nanofibrous scaffolds.ResultsThe morphology of the nanofibrous scaffolds was studied by scanning electron microscopy, showing successful nanofibrous scaffolds. Fourier transform infrared spectroscopy demonstrated the successful incorporation of the material used to produce the produced nanofibrous scaffolds. Thermal studies with thermogravimetric analysis and differential scanning calorimetry indicated that the DLS had high thermal stability. The DLS also showed good in vitro characteristics in terms of improved swelling ratio and contact angle. The mechanical results revealed that the DLS had an improved tensile strength of 3.88 MPa compared with the second layer of scaffold (2.81 MPa). The release of drugs from the scaffold showed different profiles for the two drugs. Lidocaine hydrochlo ride exhibited an initial burst release (66% release within an hour); however, mupirocin exhibited only a 5% release. Furthermore, the DLS nanofibers displayed highly effective antibacterial activities against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa and were nontoxic to fibroblasts.ConclusionThe fabricated DLS exhibited excellent hydrophilicity, cytocompatibility, sustained drug release, and antibacterial activity, which are favorable qualities for its use as a multifunctional material for wound dressing applications.

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Section: Ftirmentioning

confidence: 98%

Electrospun PCL/mupirocin and chitosan/lidocaine hydrochloride multifunctional double layer nanofibrous scaffolds for wound dressing applications

Li¹,

Wang²,

Yang³

et al. 2018

IJN

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“…It is also a physical barrier against microbes and other external aggressions, while allowing gas exchange. It also has the capacity of being removed from the wound without pain and without damaging the newly formed tissue . Additionally, when used as a wound dressing, BC optical transparency provides the possibility of using laser‐based imaging diagnosis, such as multiphoton tomography, optical coherence tomography, and confocal laser scanning microscopy, allowing a noninvasively follow‐up of the wound‐healing development …”

Section: Applicationsmentioning

confidence: 99%

Latest Advances on Bacterial Cellulose‐Based Materials for Wound Healing, Delivery Systems, and Tissue Engineering

Carvalho

Guedes

Sousa

et al. 2019

Biotechnology Journal

110

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Bacterial cellulose (BC) is a nanocellulose form produced by some nonpathogenic bacteria. BC presents unique physical, chemical, and biological properties that make it a very versatile material and has found application in several fields, namely in food industry, cosmetics, and biomedicine. This review overviews the latest state‐of‐the‐art usage of BC on three important areas of the biomedical field, namely delivery systems, wound dressing and healing materials, and tissue engineering for regenerative medicine. BC will be reviewed as a promising biopolymer for the design and development of innovative materials for the mentioned applications. Overall, BC is shown to be an effective and versatile carrier for delivery systems, a safe and multicustomizable patch or graft for wound dressing and healing applications, and a material that can be further tuned to better adjust for each tissue engineering application, by using different methods.

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“…A wound is a defect or breakage of the skin caused by physical or thermal damage or the presence of underlying medical or physiological conditions, which may render the area physiologically unstable and even lead damage to normal body processes . Wound healing is the result of a series of biological molecules and stem cells working together to promote wound repair at all levels, which is considered to be one of the most complex dynamic biological processes .…”

Section: Introductionmentioning

confidence: 99%

Advances and Impact of Antioxidant Hydrogel in Chronic Wound Healing

Han

et al. 2020

Adv Healthcare Materials

405

305

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The accelerating and thorough treatment of chronic wounds still represents a major unmet medical need owing to the complex symptoms resulting from metabolic disorder of the wound microenvironment. Although numerous strategies and bioactive hydrogels are developed, an effective and widely used method of chronic wound treatment remains a bottleneck. With the aim to accelerate chronic wound healing, many hydrogel dressings with antioxidant functions have emerged and are proven to accelerate wound healing, especially for chronic wound repair. The new strategy in chronic wound treatment brought by antioxidant hydrogels is of great significance to human health. Here, the application of antioxidant hydrogels in the repair of chronic wounds is discussed systematically, aiming to provide an important theoretical reference for the further breakthrough of chronic wound healing.

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Flexible Amoxicillin-Grafted Bacterial Cellulose Sponges for Wound Dressing: In Vitro and in Vivo Evaluation

Cited by 198 publications

References 31 publications

Electrospun PCL/mupirocin and chitosan/lidocaine hydrochloride multifunctional double layer nanofibrous scaffolds for wound dressing applications

Electrospun PCL/mupirocin and chitosan/lidocaine hydrochloride multifunctional double layer nanofibrous scaffolds for wound dressing applications

Latest Advances on Bacterial Cellulose‐Based Materials for Wound Healing, Delivery Systems, and Tissue Engineering

Advances and Impact of Antioxidant Hydrogel in Chronic Wound Healing

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