Flaxseed supplementation on glucose control and insulin sensitivity: a systematic review and meta-analysis of 25 randomized, placebo-controlled trials

Mohammadi-Sartang, Mohsen; Sohrabi, Zahra; Barati‐Boldaji, Reza; Raeisi‐Dehkordi, Hamidreza; Mazloom, Zohreh

doi:10.1093/nutrit/nux052

Cited by 37 publications

(26 citation statements)

References 67 publications

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“…Flaxseed contains n-3 fatty acids alpha-linolenic acid has which has previously been shown to have a positive impact upon glycaemic control [37,38]. A previous systematic review and meta-analysis [14] showed that there was a significant association between flaxseed supplementation and a reduction in blood glucose; however, when subgroup analysis was completed the significant reduction in blood glucose were found only in studies using whole flaxseed but not flaxseed oil and lignan extract. However, the flaxseed oil was approaching significance (p = 0.08).…”

Section: Discussionmentioning

confidence: 99%

“…However, the flaxseed oil was approaching significance (p = 0.08). Although the systematic review by Mohammadi-Sartang et al [14] highlighted that flaxseed lignan extract had no significant impact on blood glucose, plant lignan has been suggested to be able to lower the risk of cardiovascular diseases as well as inhibit the effect of developing type two diabetes by reducing inflammatory response and insulin resistance [39]. It has been shown that flaxseed lignan secoisolariciresinol diglucoside restricts expression of the phosphoenolpyruvate carboxykinase gene, which is considered the main enzyme in glucose synthesis in the liver [40,41].…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have demonstrated that flaxseed can be effective at lowering and stabilising the blood glucose response in healthy, pre-diabetic and diabetic individuals [11][12][13][14][15]. The question remains as to whether flaxseed is more effective at maintaining blood glucose at the normal level over 24 h when the portion is given once or spread out throughout the day.…”

Section: Introductionmentioning

confidence: 99%

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The effect of a split portion of flaxseed on 24-h blood glucose response

et al. 2020

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Purpose Flaxseed can be effective at lowering and stabilising blood glucose responses. The aim of this study was to determine whether flaxseed could lower blood glucose response more effectively when consumed as a single portion of 30 g, or a split portion consumed three times per day (10 g flaxseed per portion). Methods The study was a randomised, repeated measures, cross-over design. Fifteen healthy participants consumed either (1) three flaxseed muffins containing a total of 30 g of flaxseed once in the morning, (2) three flaxseed muffins consumed at three different timepoints across the day (10 g flaxseed per muffin) or (3) three control muffins consumed at three different timepoints across the day (0 g flaxseed). The 24-h blood glucose response was measured using a continuous glucose monitor. Results The results of this study demonstrated that flaxseed muffins given three times a day were effective at lowering and maintaining blood glucose levels over 24 h, compared to the control muffins and that both flaxseed treatments resulting in a lower blood glucose iAUC during the night. Conclusion The results of this study indicated that adding flaxseed to a daily diet produced a lower glucose profile over 24 h in a free-living context compared to the control muffins. Keywords Flaxseed • Linseed • Blood glucose • Continuous glucose monitor • Blood glucose incremental area under the curve (iAUC) • 24 blood glucose profile

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The effect of a split portion of flaxseed on 24-h blood glucose response

et al. 2020

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“…Results from reviews and metanalyses show that flaxseed consumption has beneficial effects on blood pressure [274], lipid profile [275] and glucose metabolism [276]. Evidence regarding its effect on body composition indices, however, is controversial [277].…”

Section: Flaxseedmentioning

confidence: 99%

Current Evidence to Propose Different Food Supplements for Weight Loss: A Comprehensive Review

et al. 2020

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The use of food supplements for weight loss purposes has rapidly gained popularity as the prevalence of obesity increases. Navigating through the vast, often low quality, literature available is challenging, as is providing informed advice to those asking for it. Herein, we provide a comprehensive literature revision focusing on most currently marketed dietary supplements claimed to favor weight loss, classifying them by their purported mechanism of action. We conclude by proposing a combination of supplements most supported by current evidence, that leverages all mechanisms of action possibly leading to a synergistic effect and greater weight loss in the foreseen absence of adverse events. Further studies will be needed to confirm the weight loss and metabolic improvement that may be obtained through the use of the proposed combination.

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“…The results indicate that flaxseed supplementation may improve glycemic control. The changes may be more pronounced with whole flaxseed consumption, in subjects with higher baseline glucose levels, and in interventions longer than twelve weeks [71]. Adiponectin, which is produced by adipocytes and acts as a modulator of insulin sensitivity, has been shown to be low in insulin-resistant states.…”

Section: Clinical Potential For Improving Insr In Pcosmentioning

confidence: 99%

Targeting Metabolic Consequences of Insulin Resistance in Polycystic Ovary Syndrome by D-chiro-inositol and Emerging Nutraceuticals: A Focused Review

Davinelli

Nicolosi

Cesare

et al. 2020

JCM

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Polycystic ovary syndrome (PCOS) is a complex disorder associated with ovarian dysfunction, infertility, menstrual irregularity, and hormonal impairments. Over the last decade, several studies have shown that some PCOS women have insulin resistance (InsR) and hyperinsulinemia, apart from being overweight or obese. Therefore, a crucial clinical aspect is that PCOS patients might develop glucose intolerance and type 2 diabetes. Insulin-sensitizing drugs have been used as first-line treatment to improve hyperinsulinemia in women with PCOS. Although reducing PCOS symptoms and signs, several used insulin-sensitizer drugs may induce side effects, which reduces compliance. D-chiro-inositol (DCI), which is a naturally occurring stereoisomer of inositol, has been classified as an insulin-sensitizer and seems to mitigate multiple InsR-related metabolic alterations in PCOS with a safe profile. However, according to a multi-targeted design, the supplementation with DCI can be synergistically integrated by combining other potential insulin-sensitizing drugs and/or nutraceuticals. The literature provides the initial support for using several unexplored nutraceutical interventions that may target relevant metabolic abnormalities associated with InsR in PCOS. With a need to promote interest in clinical research, this review aims to discuss the efficacy of DCI and the role of emerging nutraceuticals for managing InsR in PCOS.

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Flaxseed supplementation on glucose control and insulin sensitivity: a systematic review and meta-analysis of 25 randomized, placebo-controlled trials

Abstract: Whole flaxseed, but not flaxseed oil and lignan extract, has significant effects on improving glycemic control. Further studies are needed to determine the benefits of flaxseed on glycemic parameters.

Cited by 37 publications

References 67 publications

The effect of a split portion of flaxseed on 24-h blood glucose response

The effect of a split portion of flaxseed on 24-h blood glucose response

Current Evidence to Propose Different Food Supplements for Weight Loss: A Comprehensive Review

Targeting Metabolic Consequences of Insulin Resistance in Polycystic Ovary Syndrome by D-chiro-inositol and Emerging Nutraceuticals: A Focused Review

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