Current Evidence to Propose Different Food Supplements for Weight Loss: A Comprehensive Review

Watanabe, Mikiko; Risi, Renata; Masi, Davide; Caputi, Alessandra; Balena, Angela; Rossini, Giovanni; Tuccinardi, Dario; Mariani, Stefania; Basciani, Sabrina; Manfrini, Silvia; Gnessi, Lucio; Lubrano, Carla

doi:10.3390/nu12092873

Cited by 53 publications

(66 citation statements)

References 313 publications

(340 reference statements)

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“…There was a significant difference (p < 0.05) observed in the mean score of the BMI with SD in the PV group at 26.44 ± 2.7 and 26.36 ± 2.65. These antiadipogenic effects were proven by many other researchers [27,28].…”

Section: Effect On Bmimentioning

confidence: 81%

Effect of Phaseolus Vulgaris on Urinary Biochemical Parameters among Patients with Kidney Stones in Saudi Arabia

et al. 2020

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The study purpose was to investigate the effect of Phaseolus Vulgaris (PV) on urinary biochemical parameters among patients with kidney stones. We conducted a randomized controlled study among 60 patients with kidney stones (size < 10 mm) in the nephrology unit of both government and private hospitals, Al-Ahsa. Urinary volume, calcium, magnesium, potassium, oxalate, uric acid, and power of hydrogen (pH) were assessed before and after the intervention of giving 250 g of PV consumption as an extract thrice weekly (2.2 L to 2.5 L per week) for 6 weeks, which was compared with control. A ‘t’ test was used with the significance at 5%. Mean score of age was 44.5 ± 10.16 in PV group and 43.73 ± 9.79 in control. Four (13.3%) and two (6.7%) had family history of kidney stones. Body mass Index (BMI) mean was 26.44 ± 2.7 and 26.36 ± 2.65 in pre and post-test, respectively, which were significant (p = 0.01017). There were significant changes (p = 0.000) in urine volume from 1962 ± 152.8 to 2005 ± 148.8, calcium 205.4 ± 11.99 to 198.4 ± 12.52, potassium 44.07 ± 3.66 to 52.15 ± 4.37, oxalate 37.12 ± 5.38 to 33.02 ± 5.71, and uric acid 6.88 ± 0.7 to 6.31 ± 0.58. In conclusion, PV is effective management for the patients with kidney stones as it increases the urinary volume and enhances the elimination of small kidney stones.

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Section: Effect On Bmimentioning

confidence: 81%

Effect of Phaseolus Vulgaris on Urinary Biochemical Parameters among Patients with Kidney Stones in Saudi Arabia

et al. 2020

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“…However, none is capable of inducing a clinically relevant weight loss, with the most effective ones (green tea) leading to a 2 kg reduction. 136 , 137 Therefore, for the time being, these natural products lack adequate clinical investigations and scientific validation to be recommended for obesity therapy.…”

Section: Treatment Of Obesity In T1d: Challenges and Opportunitiesmentioning

confidence: 99%

Obesity in Patients with Type 1 Diabetes: Links, Risks and Management Challenges

Vilarrasa¹,

José²,

Rubio³

et al. 2021

DMSO

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Obesity affects large numbers of patients with type 1 diabetes (T1D) across their lifetime, with rates ranging between 2.8% and 37.1%. Patients with T1D and obesity are characterized by the presence of insulin resistance, of high insulin requirements, have a greater cardiometabolic risk and an enhanced risk of developing chronic complications when compared to normal-weight persons with T1D. Dual treatment of obesity and T1D is challenging and no specific guidelines for improving outcomes of both glycemic control and weight management have been established for this population. Nevertheless, although evidence is scarce, a comprehensive approach based on a balanced hypocaloric diet, physical activity and cognitive behavioral therapy by a multidisciplinary team, expert in both obesity and diabetes, remains as the best clinical practice. However, weight loss responses with lifestyle changes alone are limited, so in the “roadmap” of the treatment of obesity in T1D, it will be helpful to include anti-obesity pharmacotherapy despite at present there is a lack of evidence since T1D patients have been excluded from anti-obesity drug clinical trials. In case of severe obesity, bariatric surgery has proven to be of benefit in obtaining a substantial and long-term weight loss and reduction in cardiovascular risk. The near future looks promising with the development of new and more effective anti-obesity treatments and strategies to improve insulin resistance and oxidative stress. Advances in precision medicine may help individualize and optimize the medical management and care of these patients. This review, by gathering current evidence, highlights the need of solid knowledge in all facets of the treatment of patients with obesity and T1D that can only be obtained through high quality well-designed studies.

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“…The range of health benefits reported for purple mangosteen products may reduce the symptoms of metabolic syndrome in humans by mechanisms including an insulin-sensitising response as with mangostins from fruit pulp in obese females [ 11 ] and by decreasing inflammatory markers and increasing antioxidant capacity as with a mangosteen-based beverage [ 12 ]. The limited in vivo studies in humans showing weight loss and decreased blood pressure with purple mangosteen-based products as food supplements [ 13 , 14 ] suggest that the compounds found in purple mangosteen rind could be effective in alleviating metabolic syndrome.…”

Section: Introductionmentioning

confidence: 99%

Rind from Purple Mangosteen (Garcinia mangostana) Attenuates Diet-Induced Physiological and Metabolic Changes in Obese Rats

et al. 2021

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The pulp of the purple mangosteen, Garcinia mangostana, is a popular tropical fruit but the rind containing xanthones such as α-mangostin together with procyanidins and anthocyanidins is usually discarded as waste. However, this rind has been used in South-East Asia for diarrhoea, dysentery, skin infections and wounds. As xanthones have reported anti-inflammatory and antioxidant responses, this study has determined the bioactive compounds and evaluated the effects of G. mangostana rind on physiological, metabolic, liver and cardiovascular parameters in rats with diet-induced metabolic syndrome. Rats fed a diet with increased simple sugars and saturated fats developed obesity, hypertension, increased left ventricular stiffness, dyslipidaemia and fatty liver. Administration of G. mangostana rind as 5% of the food to rats with diet-induced metabolic syndrome gave a dose of 168 mg/kg/day α-mangostin, 355 mg/kg/day procyanidins, 3.9 mg/kg/day anthocyanins and 11.8 mg/kg/day hydroxycitric acid for 8 weeks which reduced body weight and attenuated physiological and metabolic changes in rats including decreased abdominal fat deposition, decreased abdominal circumference and whole-body fat mass, improved liver structure and function and improved cardiovascular parameters such as systolic blood pressure, left ventricular stiffness and endothelial function. These responses were associated with decreased infiltration of inflammatory cells, decreased deposition of collagen in both heart and liver and decreased mean adipocyte size in retroperitoneal adipose tissues. We conclude that, in rats with diet-induced metabolic syndrome, chronic intake of G. mangostana rind decreased infiltration of inflammatory cells which decreased physiological, metabolic, liver and cardiovascular symptoms.

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Current Evidence to Propose Different Food Supplements for Weight Loss: A Comprehensive Review

Cited by 53 publications

References 313 publications

Effect of Phaseolus Vulgaris on Urinary Biochemical Parameters among Patients with Kidney Stones in Saudi Arabia

Effect of Phaseolus Vulgaris on Urinary Biochemical Parameters among Patients with Kidney Stones in Saudi Arabia

Obesity in Patients with Type 1 Diabetes: Links, Risks and Management Challenges

Rind from Purple Mangosteen (Garcinia mangostana) Attenuates Diet-Induced Physiological and Metabolic Changes in Obese Rats

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