Flaxseed reduces epithelial proliferation but does not affect basal cells in induced benign prostatic hyperplasia in rats

Ribeiro, Ilma Cely de Amorim; Costa, Carlos Alberto Soares da; Silva, Vivian Alves Pereira da; Corrêa, Lanna Beatriz Neves Silva; Boaventura, Gilson Teles; Chagas, Mauricio Alves

doi:10.1007/s00394-016-1169-1

Cited by 12 publications

(5 citation statements)

References 59 publications

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“…Similar to what has been reported on animal models [52,53], a strong utility of dietary flaxseed lignan extract in improving BPH-related LUTSs, compared to that of alpha1A-adrenoceptor blockers and 5alpha-reductase inhibitors, has been reported by Zhang et al [69]. These authors conducted a randomized clinical trial in which a placebo, 300, or 600 mg/day of secoisolariciresinol diglucoside, a flaxseed extract, were administered to 87 patients affected by BPH and found a decrease in IPSS and improvement of quality of life score and LUTSs, respectively [69].…”

Section: Studies In Humansupporting

confidence: 89%

“…In particular, higher immunohistochemical and Western blot levels of p-ERK1/2 were observed both in rats with BPH plus a high-fat diet and rats with BPH compared to those found in rats with a high-fat diet and in a control group. However, it has also been reported that the administration of flaxseed reduced epithelial cell proliferative activity in rats with BPH [52,53]; this finding led to the supposition that different fat types and contents are involved in BPH onset and maintenance. As further evidence for this hypothesis, Kayode et al emphasized that a ketogenic diet, consisting of high fat, moderate protein and low carbohydrate consumption, ameliorated testosterone propionate-induced BPH in male Wistar rats [54].…”

Section: Studies In Animal Modelsmentioning

confidence: 99%

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Relationship between Dietary Patterns with Benign Prostatic Hyperplasia and Erectile Dysfunction: A Collaborative Review

et al. 2021

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Interest in the role of dietary patterns has been consistently emerging in recent years due to much research that has documented the impact of metabolism on erectile dysfunction (ED) and/or benign prostatic hyperplasia (BPH). We conducted a non-systematic review of English articles published from 1964 to September 2021. The search terms were: (“dietary patterns” OR “diet”) AND/OR (“erectile dysfunction”) AND/OR (“benign prostatic hyperplasia”). In the present review, we have highlighted how the association between dietary patterns and two of the most frequent pathologies in urology, namely erectile dysfunction and benign prostatic hyperplasia, is present in the literature. The data suggested that a diet that is more adherent to the Mediterranean diet or that emphasizes the presence of vegetables, fruits, nuts, legumes, and fish or other sources of long-chain (n-3) fats, in addition to reduced content of red meat, may have a beneficial role on erectile function. At the same time, the same beneficial effects can be transferred to BPH as a result of the indirect regulatory effects on prostatic growth and smooth muscle tone, thus determining an improvement in symptoms. Certainly, in-depth studies and translational medicine are needed to confirm these encouraging data.

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Section: Studies In Humansupporting

confidence: 89%

Section: Studies In Animal Modelsmentioning

confidence: 99%

Relationship between Dietary Patterns with Benign Prostatic Hyperplasia and Erectile Dysfunction: A Collaborative Review

et al. 2021

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“…It seems evident that different types and compositions of fat can influence the development of BPH. De Ribeiro and colleagues suggested that flaxseed reduced the proliferation of prostate epithelial cells of rats with BPH [ 22 ]. According to the evidence from an RCT carried out in 87 patients with BPH, the flaxseed extract secoisolariciresinol diglucoside (SDG) at the dose of 300 or 600 mg/day reduced the international prostate symptom score (IPSS), increased the QoL score, and improved the grade of lower urinary tract symptoms (LUTS) (from moderate/severe to mild).…”

Section: Discussionmentioning

confidence: 99%

Beneficial Effects of the Very-Low-Calorie Ketogenic Diet on the Symptoms of Male Accessory Gland Inflammation

et al. 2022

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Introduction. Obesity exposes individuals to the risk of chronic inflammation of the prostate gland. Aim and design of the study. A longitudinal clinical study was conducted on selected overweight/obese patients with male accessory gland inflammation (MAGI) to evaluate the effects of body weight loss on their urogenital symptoms. Materials and methods. One hundred patients were selected and assigned to two groups undergoing two different nutritional programs. The first group (n = 50) started a Mediterranean diet (MedDiet) and the second (n = 50) a very-low-calorie ketogenic diet (VLCKD). Before and after three months on the diet, each patient was evaluated for body weight, waist circumference, and MAGI symptoms. The MAGI was assessed using the Structured Interview about MAGI (SI-MAGI), a questionnaire previously designed to assess the symptoms of MAGI. The questionnaire explores four domains, including urinary symptoms, ejaculatory pain or discomfort, sexual dysfunction, and impaired quality of life. Finally, in the two groups, the frequency of an α-blocker used to treat urinary tract symptoms was also evaluated. Results. Patients on MedDiet experienced significant amelioration in urinary symptoms and quality of life. Patients under VLCKD reported not only significant improvement of the same parameters, but also in ejaculatory pain/discomfort and sexual dysfunction. Finally, the percentage of patients on VLCKD taking the α-blocker decreased significantly. Moreover, patients under VLCKD showed a greater loss of body weight than those following the MedDiet. Discussion. The results of this study support the effectiveness of VLCKD in improving the symptoms of patients with MAGI. This improvement involved all of the domains of the SI-MAGI questionnaire and became manifest in a relatively short time. We suggest that a ketogenic nutritional approach can be used in overweight/obese patients with MAGI.

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“…De Amorim Ribeiro (2017) gave flax-based food to rats with induced BPH, for 20 weeks. The flax was found to have a protective effect on prostate epithelium in previously induced BPH [223].…”

Section: Polyphenolsmentioning

confidence: 99%

The Polyphenols as Potential Agents in Prevention and Therapy of Prostate Diseases

et al. 2019

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In recent years, the progress of science and medicine greatly has influenced human life span and health. However, lifestyle habits, like physical activity, smoking cessation, moderate alcohol consumption, diet, and maintaining a normal body weight represent measures that greatly reduce the risk of various diseases. The type of diet is very important for disease development. Numerous epidemiological clinical data confirm that longevity is linked to predominantly plant-based diets and it is related to a long life; whereas the western diet, rich in red meat and fats, increases the risk of oxidative stress and thus the risk of developing various diseases and pre-aging. This review is focused on the bioavailability of polyphenols and the use of polyphenols for the prevention of prostate diseases. Special focus in this paper is placed on the isoflavonoids and flavan-3-ols, subgroups of polyphenols, and their protective effects against the development of prostate diseases.

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Flaxseed reduces epithelial proliferation but does not affect basal cells in induced benign prostatic hyperplasia in rats

Abstract: These results suggest that flaxseed has a protective effect on the prostate epithelium in BPH-induced animals.

Cited by 12 publications

References 59 publications

Relationship between Dietary Patterns with Benign Prostatic Hyperplasia and Erectile Dysfunction: A Collaborative Review

Relationship between Dietary Patterns with Benign Prostatic Hyperplasia and Erectile Dysfunction: A Collaborative Review

Beneficial Effects of the Very-Low-Calorie Ketogenic Diet on the Symptoms of Male Accessory Gland Inflammation

The Polyphenols as Potential Agents in Prevention and Therapy of Prostate Diseases

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