Flaxseed on cardiovascular disease markers in healthy menopausal women: a randomized, double-blind, placebo-controlled trial

Dodin, Sylvie; Cunnane, Stephen C.; Mâsse, Benoı̂t; Lemay, André; Jacques, Hélène; Asselin, Geneviève; Tremblay‐Mercier, Jennifer; Marc, Isabelle; Lamarche, Benoı̂t; Forest, Jean‐Claude

doi:10.1016/j.nut.2007.09.003

Cited by 116 publications

(80 citation statements)

References 47 publications

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“…Table 10 summarises the findings of intervention studies where haemostatic factors have been investigated after increased consumption of ALA [119,123,128,129,139,151,228,234,235,257]. Most studies (9 out of 10) reported no significant effect of increasing ALA intake on haemostatic factors (e.g., fibrinogen concentration, prothrombin time, PAI-1 activity or factor VII activity), even when high intakes (up to 20 g/day) [128,129,139,234,235] and long durations (up to 48 weeks) [123,139,234] were used (Table 10). Overall, these finding show that increasing ALA intake, even quite markedly, does not alter haemostasis significantly.…”

Section: Platelet Aggregation and Haemostasismentioning

confidence: 99%

Metabolism and functional effects of plant-derived omega-3 fatty acids in humans

Baker

Miles

Burdge

et al. 2016

Progress in Lipid Research

321

288

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Section: Platelet Aggregation and Haemostasismentioning

confidence: 99%

Metabolism and functional effects of plant-derived omega-3 fatty acids in humans

Baker

Miles

Burdge

et al. 2016

Progress in Lipid Research

321

288

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“…Subpopulations with higher consumption of lignans display considerable lower disease frequency [7,[15][16][17][18][19][20][21][22]. In several studies, lignan-rich foods, concentrates or partially purified compounds have been shown to improve blood lipids, to enhance glycemic control and to alleviate or cure type 1 and type 2 diabetes [23][24][25][26][27]. However, the results produced in these studies, although very promising, were not homogeneous due to their different and often fragmented approaches.…”

Section: Introductionmentioning

confidence: 99%

Oilseeds ameliorate metabolic parameters in male mice, while contained lignans inhibit 3T3-L1 adipocyte differentiation in vitro

et al. 2014

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Purpose and background The focus was directed to the study of two of the most lignan-rich food sources: sesame and flaxseeds. Recent epidemiological and experimental evidences suggesting that these foods may improve metabolic functions underlying metabolic syndrome (MetS). Methods To characterize the effect of these oilseeds on metabolic functions, we conducted an experimental study aimed at preventing adiposity and metabolic imbalance in a mouse model of high-fat diet (HFD)-induced MetS. Statistical analysis was performed by two-way analysis of variance test followed by post hoc Bonferroni analysis. Results We studied the effect of the oilseeds sesame and flaxseed on metabolic parameters in mice on a HFD. When the HFD was integrated with 20 % of sesame or flaxseed flours, the mice showed a decrease in body fat, already at day 15, from time 0. The size of the adipocytes was smaller in epididymal fat, liver steatosis was inhibited, and insulin sensitivity was higher in mice on the supplemented diets. The supplemented diets also resulted in a significant increase in the serum levels of the lignan metabolites enterodiol and enterolactone compared with the controls. The expression of genes associated with the inflammatory response, glucose metabolism, adipose metabolism and nuclear receptor were altered by the oilseed-supplemented diets. Some of the most abundant lignans in these oilseeds were studied in 3T3-L1 preadipocyte cells and were effective in inhibiting adipocyte differentiation at the minimal dose of 1 nM. Conclusions The consumption of sesame and flaxseed may be beneficial to decrease metabolic parameters that are generally altered in MetS.

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“…However, due to its limited shelf-life, flaxseed was not used for human nutrition for a period of time. However, nowadays it gains attention worldwide as a functional food due to the findings that the consumption of flaxseed brings benefits to health, such as to help reducing the risk of occurrence of breast cancer, osteoporosis, diabetes, heart disease, and menopausal symptoms (DUFFY;CYR, 2003;DODIN et al, 2008;SACCO et al, 2009;THAKUR et al, 2009). …”

Section: Introductionmentioning

confidence: 99%

Effect of storage and processing of Brazilian flaxseed on lipid and lignan contents

et al. 2012

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Flaxseed has been widely studied around the world; its incorporation into products habitually consumed by human populations has been stimulated due to its unique nutritional value. The objective of this study was to evaluate the chemical composition of Brazilian flaxseed, to analyze the stability of lipids present in whole flaxseed flour (WFF) or partially defatted flaxseed flour (DFF) stored under several temperatures, and to investigate the effect of bread making on a product containing flaxseed. Whole flaxseed flour presented (g.100 g-1) 25.7 of insoluble fiber, 10.7 of soluble fiber, 38.9 of lipids, and 2.65 of lignan. Defatted flaxseed flour presented 65% less lipids, 36% more fiber and 56% more lignan than whole flaxseed flour. The fatty acid profile was maintained in the defatted flaxseed flour, and it presented a stable composition during storage under ambient temperature, refrigeration, and freezing. The fatty acid profile was similar in the bread containing defatted flaxseed flour after dough development, baking, and storage at room temperature or refrigerated. After baking, 89% of the lignan content was kept in bread. Results show that Brazilian flaxseed has an interesting chemical composition, and that defatted flaxseed, by-product of lipid extraction, presents a good stability to grind and storage under several temperatures. Thus, defatted flaxseed flour can be incorporated in bread, increasing its nutritional and functional value.

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Flaxseed on cardiovascular disease markers in healthy menopausal women: a randomized, double-blind, placebo-controlled trial

Cited by 116 publications

References 47 publications

Metabolism and functional effects of plant-derived omega-3 fatty acids in humans

Metabolism and functional effects of plant-derived omega-3 fatty acids in humans

Oilseeds ameliorate metabolic parameters in male mice, while contained lignans inhibit 3T3-L1 adipocyte differentiation in vitro

Effect of storage and processing of Brazilian flaxseed on lipid and lignan contents

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