Flaxseed oil and fish-oil capsule consumption alters human red blood cell n–3 fatty acid composition: a multiple-dosing trial comparing 2 sources of n–3 fatty acid

Barceló‐Coblijn, Gwendolyn; Murphy, Eric J.; Othman, Rgia A.; Moghadasian, Mohammed H.; Kashour, Tarek; Friel, James K.

doi:10.1093/ajcn/88.3.801

Cited by 166 publications

(157 citation statements)

References 51 publications

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“…1). The present findings indicate that palatability of the FD for rats fed the LD during the dietary treatment period was higher than that of the FD at the beginning of the self-selection period, and this contributes to greater consumption of the FD compared to the LD because there are many reports that dietary fats are absorbed very effectively from the digestive tract and an increase in plasma n-3 FA content, particularly EPA and DHA, are observed after consumption of fish oil enriched diet (4,30,(33)(34)(35)(36). These results lead us to conclude that, at the beginning of the self-selection period, rats fed the LD consumed a larger amount of the FD than rats fed the FD diet to counteract the effect of an n-3 FA shortage during the experimental period.…”

Section: Discussionmentioning

confidence: 94%

“…We concluded that ALA in the PD failed to reduce the plasma lipid concentration. Although many reports also showed that diets enriched with fish oil reduce plasma TG concentration (30,(33)(34)(35), Finnegan et al reported that 4.5 and 9.5 g ALA intervention for 6 mo failed to reduce fasting and postprandial plasma lipid concentrations (33) and Barceleó-Coblijin et al reported that 3.6 g flaxseed oil intervention for 12 wk failed to reduce plasma lipid concentrations (4). It has been reported that dietary ALA can be converted to long-chain n-3 PUFA in animals and may reproduce some of the beneficial effects of EPAϩDHA (4,5).…”

Section: Discussionmentioning

confidence: 99%

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Effect of Plant- and Fish-Oil Derived n-3 Polyunsaturated Fatty Acids on Counteraction of n-3 Fatty Acid Shortage in Adult Rats Fed a Lard Diet

Nakashima

Sato

Saito

2009

J Nutr Sci Vitaminol

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Summary These studies aimed to compare the effects of ␣ -linolenic acid (ALA) ϩ eicosapentaenoic acid (EPA) ϩ docosahexaenoic acid (DHA) on plasma-lipid concentrations and preferential fat intake of rats fed a lard diet (LD). Each of 2 groups of 4-wk-old male rats was used in studies 1 and 2. In studies 1 and 2, two groups of rats received the LD (LD group) and the fish-oil diet (FD; FD group), and the LD and the perilla-oil diet (PD; PD group), respectively (dietary treatment period). After 6 wk, 6 rats per group were sacrificed. The remaining rats in studies 1 and 2 were placed on a self-selection regimen of the LD and the FD, and the LD and the PD, respectively, for 3 wk (self-selection period). After the dietary treatment period, plasma lipid concentrations in the FD group were lower than those in the LD group. However, no significant difference in the concentrations was observed between the LD group and the PD group. At the beginning of the self-selection period, the ratio of the FD intake of the LD group was higher than that of the FD group. As the the ratio of the LD group decreased and that of the FD group increased no significant difference in the ratio was observed after the 9th day during the self-selection period. No significant difference in the ratio of the PD intake was observed between the LD group and the PD group during the selfselection period. Thus, although the FD decreased plasma lipid concentration and increased the preferential FD intake of the LD group at the beginning of the self-selection period, the PD did not. Our studies clearly show that dietary EPA ϩ DHA and ALA have different physiologic effects.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Effect of Plant- and Fish-Oil Derived n-3 Polyunsaturated Fatty Acids on Counteraction of n-3 Fatty Acid Shortage in Adult Rats Fed a Lard Diet

Nakashima

Sato

Saito

2009

J Nutr Sci Vitaminol

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“…These fatty acids are known to be crucial for normal growth and development (reviewed by Ruxton et al, 2004). They also reduce risk of cardio-vascular disease (reviewed by Givens and Gibbs, 2008), decrease incidence of age-related eye disease (SanGiovanni et al, 2008), positively alter human red blood cell fatty-acid composition (Barcelo-Coblijn et al, 2008), decrease risk of cancer and have a number of other health benefits (Berquin et al, 2008;Li et al, 2008;Mozaffarian, 2008).…”

Section: Introductionmentioning

confidence: 99%

Effect of supplementation of the maternal diet with fish oil or linseed oil on fatty-acid composition and expression of Δ5- and Δ6-desaturase in tissues of female piglets

Missotten

Smet

Raes

et al. 2009

Animal

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The present study investigated whether enrichment of the pig maternal diet with n-3 polyunsaturated fatty acids (PUFA) affects the fatty-acid composition of female piglets via enhancing of expression of the lipogenic enzymes D5-desaturase (D5d) and D6-desaturase (D6d). The sows (50% Landrace 3 50% Large White) were fed a control diet or one of the experimental diets starting at day 45 in gestation. The experimental diets were supplemented either with linseed oil or fish oil, whereas the control diet contained palm oil. Expression of D5d and D6d, and fatty-acid composition was determined by Western blotting and gas-liquid chromatography, respectively, in muscle, subcutaneous adipose tissue and liver. The highest D5d protein expression was observed in the piglets' muscle, followed by subcutaneous adipose tissue, with the lowest level in the liver. Expression of D6d in the piglets' tissues followed an opposite pattern, and was highest in the liver, followed by subcutaneous adipose tissue, with the lowest level in muscle. Supplementation of the maternal diet with fish oil or linseed oil increased the level of n-3 PUFA of the piglets in a tissue-specific manner. The response of D6d and D5d protein expression in female piglets, with average birth weight 2.4 kg, to the dietary manipulation was also tissue-specific. It is suggested that the increase in n-3 PUFA content in the progeny was related, at least partially, to the activation of D6d and D5d expression.

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“…There are convincing evidences that consumption of vegetable oils have beneficial effects on human health (Barceló-Coblijn et al, 2008;Foster, Hardy, & Alany, 2010;Schwab et al, 2006). It is mainly due to their FAs composition, with unsaturated FA as predominant.…”

Section: Discussionmentioning

confidence: 99%

Fatty acid composition and oxidative characteristics of novel edible oils in Poland

Białek

Jelińska

et al. 2016

CyTA - Journal of Food

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Plant oils are sources of unsaturated fatty acids (FA) and antioxidant compounds. Herbs, spices, and fruit seeds are potential source of oils which may be used as functional food and dietary supplements. FA profile and oxidative quality of oils (n = 28) were investigated by the chromatographic and titration methods. Peroxidability index (PI) was calculated and cluster analysis was performed. Differences in FA content show which of them is responsible for clusters allotment and also for similarities within each cluster. Oils from cluster S1 were characterized by high content of C18:2 n-6, whereas oils from cluster S2 by higher content of C16:1 and C18:1 n-9. Oils from S3 cluster were distinguished by higher amount of C18:3 n-3. A total of 4 of 17 FAs detected in all samples significantly differed among clusters. Novel oils may be an interesting functional food component, but detailed analysis is needed to confirm their applicability and human health influence. La composición de ácidos grasos y las características de aceites comestibles innovadores en Polonia RESUMENLos aceites vegetales son una fuente de ácidos grasos no saturados (FA) y compuestos antioxidantes. Las hierbas, las especies y las semillas de frutos son una fuente potencial de aceites que pueden ser utilizados como alimentos funcionales y suplementos alimentarios. Se investigaron el perfil de FA y la calidad oxidativa de los aceites (n = 28) mediante métodos de cromatografía y valoraciones. Se calculó el índice de peroxidabilidad (PI) y se realizó un análisis de conglomerados. Las diferencias en el contenido de FA mostraron aquellos que eran los responsables de la distribución de conglomerados aunque también de las similitudes en cada conglomerado. Los aceites del conglomerado S1 se caracterizaron por un alto contenido de C18:2 n-6, mientras que los aceites del conglomerado S2 por su mayor contenido de C16:1 y C18:1 n-9. Los aceites del conglomerado S3 se distinguieron por una mayor cantidad de C18:3 n-3. Cuatro de los 17 ácidos grasos que se detectaron en todas las muestras difirieron significativamente entre los conglomerados. los nuevos aceites podrían tratarse de un interesante componente alimentario funcional, sin embargo es necesario un análisis detallado para confirmar su aplicabilidad y su influencia en la salud humana. ARTICLE HISTORY

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Flaxseed oil and fish-oil capsule consumption alters human red blood cell n–3 fatty acid composition: a multiple-dosing trial comparing 2 sources of n–3 fatty acid

Cited by 166 publications

References 51 publications

Effect of Plant- and Fish-Oil Derived n-3 Polyunsaturated Fatty Acids on Counteraction of n-3 Fatty Acid Shortage in Adult Rats Fed a Lard Diet

Effect of Plant- and Fish-Oil Derived n-3 Polyunsaturated Fatty Acids on Counteraction of n-3 Fatty Acid Shortage in Adult Rats Fed a Lard Diet

Effect of supplementation of the maternal diet with fish oil or linseed oil on fatty-acid composition and expression of Δ5- and Δ6-desaturase in tissues of female piglets

Fatty acid composition and oxidative characteristics of novel edible oils in Poland

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