Flaxseed lignan lowers blood cholesterol and decreases liver disease risk factors in moderately hypercholesterolemic men

Fukumitsu, Satoshi; Aida, Kazuhiko; Shimizu, Hiroki; Toyoda, Katsuhiko

doi:10.1016/j.nutres.2010.06.004

Cited by 99 publications

(60 citation statements)

References 27 publications

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“…These may have implications in CVD prevention as oxidative damage is suggested to play a role in disease progression (Forstermann, 2008). Attenuations in total-and LDL-cholesterol have been observed only in hypercholesterolemic patients at higher lignan doses of 600 mg/day (Almario and Karakas, 2013) or in the LDL-C/HDL-C ratio (Fukumitsu, Aida, Shimizu, and Toyoda, 2010). In patients with PAD consuming MFX, enterolignans did not correlate with decreases in total-or LDL-cholesterol (Edel et al, 2015).…”

Section: Lignansmentioning

confidence: 99%

Stability of bioactives in flaxseed and flaxseed-fortified foods

Edel

Aliani

Pierce

2015

Food Research International

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Section: Lignansmentioning

confidence: 99%

Stability of bioactives in flaxseed and flaxseed-fortified foods

Edel

Aliani

Pierce

2015

Food Research International

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“…SECO, SDG also play an important role in reduction of hypercholesterolemia, atherosclerosis, hypertension and diabetes (Prasad 2000(Prasad , 2004. Daily administration of 100 mg SDG was found to be effective in reducing blood cholesterol and hepatic diseases risk in moderately hypercholesterolemic men (Fukumitsu et al 2010). Flaxseed lignans behaviour depends on biological levels of estrogen hormone.…”

Section: Health Benefitsmentioning

confidence: 99%

Flaxseed—a potential functional food source

2014

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There is currently much interest in phytochemicals as bioactive molecules of food. Functional foods are an emerging field in food science due to their increasing popularity among health conscious consumers. Flaxseed is cultivated in many parts of world for fiber, oil as well as for medicinal purposes and also as nutritional product. In this review, nutrients, anti-nutrients, functional properties, processing, metabolism and health benefits of bioactive molecules viz., essential fatty acids, lignans and dietary fiber of flaxseed are discussed.

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“…As a plant phenolic, SDG was shown in vitro to have direct hydroxyl radical scavenging properties and to inhibit lipid peroxidation [18-20]. Flaxseed lignan SDG has been reported to provide potential health benefits in several disease conditions (for review see [21]) related to hypercholesterolemia [22], diabetes [23], postmenopausal symptoms [24,25], cardiovascular health [26], metabolic syndrome and bone health [27] and other diseases. Our group has performed extensive research in characterizing the beneficial effects of FS and its lignan component in experimental models of Acute Respiratory Distress Syndrome (ARDS), Ischemia-Reperfusion Injury (IRI), radiation pneumonopathy and hyperoxia [12,13,28,29].…”

Section: Introductionmentioning

confidence: 99%

Flaxseed Mitigates Acute Oxidative Lung Damage in a Mouse Model of Repeated Radiation and Hyperoxia Exposure Associated with Space Exploration

Pietrofesa

Solomides

Christofidou‐Solomidou

2014

J Pulm Respir Med

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Background Spaceflight missions may require crewmembers to conduct extravehicular activities (EVA). Pre-breathe protocols in preparation for an EVA entail 100% hyperoxia exposure that may last for a few hours and be repeated 2-3 times weekly. Each EVA is associated with additional challenges such as low levels of total body cosmic/galactic radiation exposure that may present a threat to crewmember health. We have developed a mouse model of total body radiation and hyperoxia exposure and identified acute damage of lung tissues. In the current study we evaluated the usefulness of dietary flaxseed (FS) as a countermeasure agent for such double-hit exposures. Methods We evaluated lung tissue changes 2 weeks post-initiation of exposure challenges. Mouse cohorts (n=5/group) were pre-fed diets containing either 0% FS or 10% FS for 3 weeks and exposed to: a) normoxia (Untreated); b) >95% O2 (O2); c) 0.25Gy single fraction gamma radiation (IR); or d) a combination of O2 and IR (O2+IR) 3 times per week for 2 consecutive weeks, where 8-hour hyperoxia treatments were spanned by normoxic intervals. Results At 2 weeks post challenge, while control-diet fed mice developed significant lung injury and inflammation across all challenges, FS protected lung tissues by decreasing bronchoalveolar lavage fluid (BALF) neutrophils (p<0.003) and protein levels, oxidative tissue damage, as determined by levels of malondialdehyde (MDA) (p<0.008) and nitrosative stress as determined by nitrite levels. Lung hydroxyproline levels, a measure of lung fibrosis, were significantly elevated in mice fed 0% FS (p<0.01) and exposed to hyperoxia/radiation or the combination treatment, but not in FS-fed mice. FS also decreased levels of a pro-inflammatory, pro-fibrogenic cytokine (TGF-β1) gene expression levels in lung. Conclusion Flaxseed mitigated adverse effects in lung of repeat exposures to radiation/hyperoxia. This data will provide useful information in the design of countermeasures to early tissue oxidative damage associated with space exploration.

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Flaxseed lignan lowers blood cholesterol and decreases liver disease risk factors in moderately hypercholesterolemic men

Cited by 99 publications

References 27 publications

Stability of bioactives in flaxseed and flaxseed-fortified foods

Stability of bioactives in flaxseed and flaxseed-fortified foods

Flaxseed—a potential functional food source

Flaxseed Mitigates Acute Oxidative Lung Damage in a Mouse Model of Repeated Radiation and Hyperoxia Exposure Associated with Space Exploration

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