Flavored Food Additives on the Leaves of Piper betle L.: A Human Health Perspective

Patra, Biswajit; Deep, Saroj Kumar; Rosalin, Rosina; Pradhan, Surya Narayan

doi:10.1007/s12010-022-03912-w

Cited by 8 publications

(4 citation statements)

References 117 publications

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“…A number of P. betle compounds had proved for an alternative source of medication of human diseases through several research studies [ 26 , 27 , 28 ]. This research aimed to investigate the inhibitory action of alpha-amylase and alpha-glucosidase by predicting the binding affinity among the P. betle phytochemicals, applying in silico molecular docking studies and molecular dynamic simulation.…”

Section: Discussionmentioning

confidence: 99%

Molecular Docking and Dynamics Simulation of Natural Compounds from Betel Leaves (Piper betle L.) for Investigating the Potential Inhibition of Alpha-Amylase and Alpha-Glucosidase of Type 2 Diabetes

et al. 2022

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Piper betle L. is widely distributed and commonly used medicinally important herb. It can also be used as a medication for type 2 diabetes patients. In this study, compounds of P. betle were screened to investigate the inhibitory action of alpha-amylase and alpha-glucosidase against type 2 diabetes through molecular docking, molecular dynamics simulation, and ADMET (absorption, distribution, metabolism, excretion, and toxicity) analysis. The molecule apigenin-7-O-glucoside showed the highest binding affinity among 123 (one hundred twenty-three) tested compounds. This compound simultaneously bound with the two-target proteins alpha-amylase and alpha-glucosidase, with high molecular mechanics-generalized born surface area (MM/GBSA) values (ΔG Bind = −45.02 kcal mol−1 for alpha-amylase and −38.288 for alpha-glucosidase) compared with control inhibitor acarbose, which had binding affinities of −36.796 kcal mol−1 for alpha-amylase and −29.622 kcal mol−1 for alpha-glucosidase. The apigenin-7-O-glucoside was revealed to be the most stable molecule with the highest binding free energy through molecular dynamics simulation, indicating that it could compete with the inhibitors’ native ligand. Based on ADMET analysis, this phytochemical exhibited a wide range of physicochemical, pharmacokinetic, and drug-like qualities and had no significant side effects, making them prospective drug candidates for type 2 diabetes. Additional in vitro, in vivo, and clinical investigations are needed to determine the precise efficacy of drugs.

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Section: Discussionmentioning

confidence: 99%

Molecular Docking and Dynamics Simulation of Natural Compounds from Betel Leaves (Piper betle L.) for Investigating the Potential Inhibition of Alpha-Amylase and Alpha-Glucosidase of Type 2 Diabetes

et al. 2022

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“…According to some studies, combining piper leaves essential oil with antibiotics may have an impact on the oral bacteria. 15 Betel leaves, which have valuable medicinal and nutritional qualities, are traditionally chewed after meals. It creates an enzyme that aids in digestion and acts as a breath freshener in addition to containing some vitamins and minerals.…”

Section: Antimicrobialmentioning

confidence: 99%

Nutraceuticals of nano-betel (Piper betle L.) leaves: prevent COVID-19 and oral cavity disease

Agung

Wahjuni²,

Wedagama³

et al. 2022

Bali Med J.

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Introduction: Betel leaf is very popular in Asia and known to have a function as traditional medicine. And is often referred to as the "Golden Heart of Nature". This is because the betel leaf has an effect such as antimicrobial, antiviral, radioprotective, antioxidant, antiseptic, bactericidal, anti-inflammatory, antiallergic, wound healing, antiplatelet, antibacterial, antifungal, and immunomodulatory activity. Nutraceutical nano-betel leaf extract contains rich in minerals, vitamins, antioxidants, phenolic compounds, and essential oils. Effectively protects the mouth from pathogens. This research aims to review the nutraceuticals of nano-betel leaf extract to prevent COVID-19 and oral cavity disease. Methods: This systematic review study was conducted through six steps: (1) framing the questions (based on theory); (2) Run a search (on Scopus, Google Scholar, EBSCO, ProQuest, and Science Direct publishing articles from 2020 to 2022); (3) Determine the relevant research; (4) Determine the articles come from diverse backgrounds; (5) Extraction of data from individual studies; (6) Synthesis of results using the narrative method. Results: Betel leaf contains nutrients for oral health, immunomodulators, and COVID-19, namely protein, amino acids, vitamins A, B, C, and K, as well as minerals such as Mg, K, Ca, Fe, I, P, Zn, essential oil (eugenol, hydroxylchavicol, allylpyrocatechol, quercetin, etc). Betel leaf nano extract has a significant role as antioxidants, anti-inflammatory, antimicrobial, and antivirus, which act as anti-oral cavity disease and anti-COVID-19. Betel leaf nano extract has a significant role in curing various oral cavity diseases related to COVID-19, including fungal infections, toothache, conjunctivitis, re-current HSV, oral ulcerations, xerostomia or decreased salivary flow, and gingivitis. Conclusion: Betel leaf nano extract has a significant role in curing oral cavity disease and COVID-19. It is recommended that research into the oral disease and COVID-19 drugs combined with viable ingredients substances from betel leaf.

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“…The essential oils found in betel leaves are responsible for their flavor and aroma, which are vital for creating their unique taste. Furthermore, these essential oils are used in the production of perfumes and mouth fresheners [5] .…”

Section: Introductionmentioning

confidence: 99%

Ultrasound assisted extraction of phytochemicals from Piper betel L.

Singh,

Pandey,

Singh

et al. 2024

Ultrasonics Sonochemistry

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Flavored Food Additives on the Leaves of Piper betle L.: A Human Health Perspective

Cited by 8 publications

References 117 publications

Molecular Docking and Dynamics Simulation of Natural Compounds from Betel Leaves (Piper betle L.) for Investigating the Potential Inhibition of Alpha-Amylase and Alpha-Glucosidase of Type 2 Diabetes

Molecular Docking and Dynamics Simulation of Natural Compounds from Betel Leaves (Piper betle L.) for Investigating the Potential Inhibition of Alpha-Amylase and Alpha-Glucosidase of Type 2 Diabetes

Nutraceuticals of nano-betel (Piper betle L.) leaves: prevent COVID-19 and oral cavity disease

Ultrasound assisted extraction of phytochemicals from Piper betel L.

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