Flavonol glycosides in the petal of Rosa species as chemotaxonomic markers

Ochir, Sarangowa; Kanazawa, Tsutomu; Nishizawa, Makoto; Myoda, Takao; Bai, Chang-Xi; Yamagishi, Takashi

doi:10.1016/j.phytochem.2014.08.013

Cited by 35 publications

(33 citation statements)

References 12 publications

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“…Fragmentation of this peak in high‐energy MS resulted in product ions of m/z 315.0699 (galloyl‐glucosyl moiety), m/z 303.0496 (protonated quercetin), and m/z 153.0208 (galloyl moiety). Thus peak 58 was identified as quercetin galloyl‐glucoside . In high‐energy MS, peaks 93, 97, 105, 106, 108, and 109 all showed ion of m/z 303.05, consistent with protonated quercetin produced by cleavage of different acyl glucosyl moieties.…”

Section: Resultsmentioning

confidence: 86%

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Multiconstituent identification in root, branch, and leaf extracts of Juglans mandshurica using ultra high performance liquid chromatography with quadrupole time‐of‐flight mass spectrometry

Wang

Liu

et al. 2017

J of Separation Science

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As a traditional medicinal plant, Juglans mandshurica has been used for the treatment of cancer. Different organs of this plant showed anti-tumor activity in clinic and laboratory. Comparative identification of constituents in different plant organs is essential for investigation of the relationship between chemical constituents and pharmacological activities. For this aim, the roots, branches, and leaves of J. mandshurica were extracted with 50% v/v methanol and then subjected to ultra-high performance liquid chromatography with quadrupole time-of-flight mass spectrometry analysis conducted under low and high energy. As a result, we have to date identified 111 compounds consisting of 56 tannins, 29 flavonoids, 13 organic acids, 8 naphthalene derivatives, and 5 anthracenes. Five compounds, namely, diquercetin trihydroxy-truxinoyl-glucoside, two quercetin kaempferol dihydroxy-truxinoyl-glucosides, syringoyl-tri-galloyl-O-glucose, and dihydroxy-naphthalene syringoyl-glucoside, were tentatively identified as new compounds. Of the compounds identified, 76 were found in the root extract, 67 in the branch extract, and 37 in the leaf extract. Only six compounds including four organic acids and two tannins were found in all three extracts. We developed a rapid and sensitive ultra high performance liquid chromatography with quadrupole time-of-flight mass spectrometry approach to identify multiple constituents of complex extracts without separation and ion selection. The results presented provide useful information on further research of the bioactive compounds of J. mandshurica.

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Section: Resultsmentioning

confidence: 86%

“…Peak 58 was assigned the formula C 28 , and m/z 153.0208 (galloyl moiety). Thus peak 58 was identified as quercetin galloyl-glucoside [42].…”

Section: Identification Of Flavonoidsmentioning

confidence: 99%

Multiconstituent identification in root, branch, and leaf extracts of Juglans mandshurica using ultra high performance liquid chromatography with quadrupole time‐of‐flight mass spectrometry

Wang

Liu

et al. 2017

J of Separation Science

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“…10 It has been identified that the main effective constituents of Rosa rugosa are flavonoids. 11 Our collaborator have proved that flavonoids extracted from petals of Xinjiang Sprig Rosa rugosa could attenuate acute myocardial injury induced by ischemia/ reperfusion in isolated rats' hearts. 12 However, no further in vivo study has been performed to confirm the protective effects of Rosa rugosa flavonoids (RRF) on MIRI so far.…”

Section: Introductionmentioning

confidence: 97%

“…The ministry of health of the People's Republic of China pharmaceutical standards: the archies of Uighur medicine), a Uighur medicine, has long been used in clinic for prevention and treatment of coronary artery disease (CAD) in Xinjiang province . It has been identified that the main effective constituents of Rosa rugosa are flavonoids . Our collaborator have proved that flavonoids extracted from petals of Xinjiang Sprig Rosa rugosa could attenuate acute myocardial injury induced by ischemia/reperfusion in isolated rats’ hearts .…”

Section: Introductionmentioning

confidence: 98%

Rosa rugosa flavonoids alleviate myocardial ischemia reperfusion injury in mice by suppressing JNK and p38 MAPK

et al. 2017

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Objective: Although Rosa rugosa has been applied for preventing coronary artery disease, the pharmacological mechanism is little explored. In this study, the effects and mechanisms of Rosa rugosa flavonoids (RRF) on myocardial ischemia reperfusion injury (MIRI) were investigated. Methods:Mice were pretreated by intragastric administration of 600 mg/kg RRF for 7 days. Then MIRI was induced by 45 minutes coronary artery ligation and 3 hours reperfusion. Myocardial infarct size (MIS) and histopathology, activities of myocardial enzymes, and effects of RRF on inflammation and apoptosis were evaluated.Results: Pretreating the mice with RRF significantly reduced MIS and inhibited activity of plasma myocardial enzymes. Activity of the enzymes associated with anti-oxidation, SOD, and TEAC, and mRNA expression of NOX2 were significantly elevated. RRF pretreatment significantly decreased the translocation of p65 from the cytoplasm into the nucleus and reduced the expression of the pro-inflammatory cytokines, IL-6 and IL-1β. RRF pretreatment also significantly prevented the expression of caspase-3 and Bax, and increased the expression of Bcl-2. And RRF inhibited the phosphorylation of JNK and p38 MAPK.Conclusions: RRF significantly inhibited MIRI through anti-oxidative, anti-inflammatory, and anti-apoptosis effects, and mechanisms were associated with its inhibition on phosphorylation of JNK and p38 MAPK. K E Y W O R D Santi-apoptosis, anti-inflammation, anti-oxidation, mitogen-activated protein kinase, myocardial ischemia reperfusion injury, rosa rugosa flavonoids

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“…Less work has been done on the fingerprint comparison of rose extracts using statistical analysis. This type of approach has been used for phylogenetic purposes and has shown that anthocyanins or flavonol glycosides can be used as rose taxonomic markers, with respect to the different rose subsections (Biolley et al, 1992(Biolley et al, , 1994, Mikanagi et al, 1995, Mikanagi et al, , 2000Raymond et al, 1995;Grossi et al, 1998;Ghose et al, 2013;Sarangowa et al, 2014). These interesting studies have provided key information on the understanding of the rose selection process which began in the nineteenth century.…”

Section: Introductionmentioning

confidence: 99%

Molecular Fingerprint Comparison of Closely Related Rose Varieties based on UHPLC‐HRMS Analysis and Chemometrics

Riffault-Valois

Blanchot

Colas

et al. 2016

Phytochemical Analysis

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Flavonol glycosides in the petal of Rosa species as chemotaxonomic markers

Cited by 35 publications

References 12 publications

Multiconstituent identification in root, branch, and leaf extracts of Juglans mandshurica using ultra high performance liquid chromatography with quadrupole time‐of‐flight mass spectrometry

Multiconstituent identification in root, branch, and leaf extracts of Juglans mandshurica using ultra high performance liquid chromatography with quadrupole time‐of‐flight mass spectrometry

Rosa rugosa flavonoids alleviate myocardial ischemia reperfusion injury in mice by suppressing JNK and p38 MAPK

Molecular Fingerprint Comparison of Closely Related Rose Varieties based on UHPLC‐HRMS Analysis and Chemometrics

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