Flavonol Glycosides and Novel Iridoid Glycoside from the Leaves of <i>Morinda citrifolia</i>

Sang, Shengmin; Cheng, Xiaofang; Zhu, Nanqun; Stark, Ruth E.; Badmaev, Vladimir; Ghai, Geetha; Rosén, Robert; Ho, Chi‐Tang

doi:10.1021/jf010492e

Cited by 77 publications

(68 citation statements)

References 14 publications

(17 reference statements)

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“…Chromosomal stickiness values were 0.5% in negative control and 3.25% in posi- As such M. citrifolia aqueous extracts have protective effect against the oxidative damage induced by H 2 O 2 . This protective effect may be due to the anthraquinones present in M. citrifolia leaves (Sang et al 2001, Zin et al 2006. Recent studies revealed the antigenotoxic effects of noni juice against the chromosomal aberration and sister chromatid exchange induced by a chemotherapeutic agent, mitomycin C (MMC) in human lymphocytes (Treetip et al 2008).…”

Section: Resultsmentioning

confidence: 99%

Evaluation of anti-genotoxicity of the leaf extracts of Morinda citrifolia Linn.

Sreeranjini¹,

Siril²

2011

Plant Soil Environ.

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Morinda citrifolia Linn. (family Rubiaceae) is a small tree occurring in tropical areas of the world. The plant contains several medicinally active components that exhibit the therapeutic effects such as antibacterial, antiviral and anticancer activities. Anti-genotoxic effects of aqueous extracts prepared using dried leaves of M. citrifolia was studied. Allium cepa root tip meristem cells treated with 7% hydrogen peroxide were used for eliciting antigenotoxicity. For this purpose experiments were performed with A. cepa onion bulbs treated for 24 h with different concentrations (15 or 30 g/L) of aqueous extract with or without pre-treatment (1 h) with 7% hydrogen peroxide. A significant reduction in mitotic index was recorded in treatment groups over negative control. Chromosomal aberrations such as breaks, bridges, stickiness and polar deviations were observed in positive control and treatment groups. The highest (21.48) percentage of chromosomal aberrations was noticed in positive control. A significant reduction in chromosomal aberrations (9.39) was recorded in root tips treated with hydrogen peroxide followed by 15 g/L extract. H 2 O 2 induced chromosomal aberrations were reduced due to leaf extract treatment indicates antimutagenic potential of the M. citrifolia. The observations suggest that M. citrifolia aqueous leaf extracts have antimitotic and anti-genotoxic effects; consequently oxidative stress induced aberrations due to H 2 O 2 are efficiently restored in the extract treated A. cepa root meristem cells.

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Section: Resultsmentioning

confidence: 99%

Evaluation of anti-genotoxicity of the leaf extracts of Morinda citrifolia Linn.

Sreeranjini¹,

Siril²

2011

Plant Soil Environ.

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“…These mice remained tumor-free for their entire lifespan. Two months later, four tumor cell-resistant mice from the fNE and BuOH groups were rechallenged with 5x10 6 live S180 tumor cells/mouse i.p. The mice completely rejected this second tumor cell challenge, indicating that an effective immune response had been activated.…”

Section: Resultsmentioning

confidence: 99%

“…A variety of major natural products have been identified in the noni plant thus far (1,2). Two novel glycosides and a new unusual iridoid, known as citrifolinoside, isolated from noni were shown to have an inhibiting effect on activator protein-1 (AP-1) transactivation and cell transformation in the mouse epidermal JB6 cell line (3)(4)(5)(6)(7). Although its traditional uses primarily involved topical application of leaves and roots, the noni fruit has been more popular for modern usage (8).…”

Section: Introductionmentioning

confidence: 99%

Antitumor activity of fermented noni exudates and its fractions

Chang

Wall

et al. 2012

Molecular and Clinical Oncology

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Abstract. Noni has been extensively used in folk medicine by Polynesians for over 2000 year. Recent studies have shown that noni has a wide spectrum of therapeutic activities including inhibition of angiogenesis, anti-inflammatory effects and anticancer activities. Intraperitoneal (i.p.) injection of fermented noni exudates (fNE) were previously found to induce significant tumor rejection in a S180 mouse sarcoma tumor model, while natural killer (NK) cells were demonstrated to be markedly involved in fNE-induced antitumor activity. In this study, fNE was partitioned into three fractions and their antitumor effects were examined using i.p. injection or as water supplement. The in vivo animal study results showed that when delivered by i.p. injection, n-butanol fraction of fNE (BuOH) effectively rejected (100%) tumor challenge and eradicated existing tumors (75%). When delivered as a water supplement, 62.5% of the mice receiving the n-butanol or ethyl acetate fractions resisted tumor cells. The tumor-resistant mice effectively rejected more and higher doses of tumor challenge, indicating that the immune system was activated. The findings confirm those of an earlier study showing fNE to have antitumor activity and demonstrating that the n-butanol fraction of fNE contains active antitumor components, to be further identified. More importantly, the antitumor effect of fNE and its fractions as water supplements renders a significant potential for identifying novel and powerful new dietary products for cancer prevention.

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“…Flavonol glycosides appear to predominate in M. citrifolia L. leaves; rutin and other flavonol glycosides have previously been identified in raw M. citrifolia L. leaves (Sang et al, 2001a). However, the presence of flavonol aglycones in M. citrifolia L. leaves has not been previously reported.…”

Section: Fig 1 Unripe Fruitmentioning

confidence: 91%

“…Previous phytochemical studies revealed that M. citrifolia L. leaves contain a variety of phytochemical constituents, including terpenoids (Ahmad & Bano, 1980;Saludes et al, 2002;Takashima et al, 2007) phytosterols, fatty acids and their glycosides (Takashima et al, 2007) iridoids and their glycosides (Sang et al, 2001 a,b,c,d;Sang et al, 2003) and flavonol glycosides (Sang et al, 2001a).…”

Section: Fig 1 Unripe Fruitmentioning

confidence: 99%