Flavonoids with antibacterial and antioxidant potentials from the stem bark of Uapaca heudelotti

Achika, J.I.; Ayo, Rachael Gbekele-Oluwa; Oyewale, A. O.; Habila, James D.

doi:10.1016/j.heliyon.2020.e03381

Cited by 15 publications

(12 citation statements)

References 20 publications

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“…The phytochemical screening result of CR extracts exposed the presence of avonoids, phenols and tannins whereas VS extract contained saponins, avonoids and phenols and tannins (Table 1).Previous data related to phytochemical screening exposed that ethanolic extract of VS showed the presence of amino acids, reducing sugars and avonoids (12).These phytochemical constituents in medicinal plants contain antioxidant activity, play role in plant defense; act as toxic material to the pathogens (38,39).…”

Section: Discussionmentioning

confidence: 95%

Phytochemical Screening, Antioxidant, Antibacterial, Antifungal Potential and in vivo Acute Toxicity of the Crude Extract of Cordia Rothii and Viola Serpens

Zubair

Naveed

Mikrani

et al. 2020

Preprint

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Background: Plants contain numerous bioactive compounds with valuable pharmacological activities and can be used as a novel therapeutic agent. Methods: The objective of the current study was to evaluate phytochemical screening, antioxidant, antibacterial, antifungal, and acute toxicity capacity of Cordia rothii (CR) and Viola serpens (VS) plant extract. Results: The phytochemical screening revealed the presence of saponins, tannins, anthraquinones, and flavonoids contents. Antioxidant activity of both extracts was measured by total phenolic, total flavonoid content, DPPH, and reducing power capacity. IC50 value of CR and VS extract was calculated as 0.039 ± 0.05, 0.05 ± 0.07 mg/ml respectively. Both extract have antibacterial activity against S. aureus and S. epidermidis, whereas VS is inactive against E. coli. Antifungal activity was not found in both CR and VS extract. The LD50 of the test substance was also estimated to be over 10 g/kg body weight. Conclusions: The conclusion indicates that folkloric uses of both plants in traditional settings, the extracts possess antibacterial activity with remarkable antioxidant ability.

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Section: Discussionmentioning

confidence: 95%

Phytochemical Screening, Antioxidant, Antibacterial, Antifungal Potential and in vivo Acute Toxicity of the Crude Extract of Cordia Rothii and Viola Serpens

Zubair

Naveed

Mikrani

et al. 2020

Preprint

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“…So far, some of these compounds have been identified in methanol extracts of Echeveria species as: kaempferol-3-O-glucoside in E. subrigida, epigallocatechin gallate in E. kimnachii, and lupeol in both E. craigiana and E. kimnachii [43]. These compounds isolated from other plants have shown antibacterial activities against Gram-positive and Gram-negative bacteria [44][45][46], furthermore, other components of plants extract, as essential oils, as those from Atalantia sessiflora, have antibacterial and antiparasitic activities [47], but their mechanisms of action are unknown.…”

Section: Discussionmentioning

confidence: 99%

Bacteriostatic effect of Echeveria extracts on diarrheagenic E. coli pathotypes and non-cytotoxicity on human Caco-2 cells

Olivas-Quintero

Bernal-Reynaga

López-Saucedo

et al. 2022

J Infect Dev Ctries

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Introduction: Diarrheagenic Escherichia coli pathotypes are important aetiological agents of diarrhoeal illness among children from less developed areas, worldwide. Diarrheagenic E. coli pathotypes strains are increasingly becoming drug resistant, thus effective and accessible therapeutic alternatives are required for their treatment; herbal extracts may be a potential alternative. Aims: to evaluate Echeveria craigiana, E. kimnachii, and E. subrigida methanol extracts antibacterial effect on six diarrheagenic E. coli reference strains and on human colorectal adenocarcinoma cells viability and cytokine production. Methodology: Diarrheagenic E. coli pathotypes reference strains: typical enteropathogenic E2348/69, enterotoxigenic H10407, enterohaemorrhagic O157:H7/EDL933, enteroinvasive E11, diffusely adherent C18451-A, and enteroaggregative 042 E. coli. E craigiana, E. kimnachii, and E. subrigida leaves, collected at Sinaloa, Mexico, were freeze-dried and macerated in methanol solvent. Antibacterial activity was determined by a novel method developed in our laboratory, bacterial oxygen consumption by polarographic oxygen electrode technique and membrane integrity by two methods (live/dead and protein leakage assays). Colorectal adenocarcinoma cells viability by MTT assay and cytokine production using a Cytometric Bead Array kit. Results: Extracts concentrations of 100 μg/mL and 5-hour incubation, reduced more than 93% the growth of all diarrheagenic E. coli pathotypes tested strains and significantly decreased bacterial oxygen consumption, like bacteriostatic antibiotics. After 24-hour incubation methanol extracts had a differential antibacterial effect on each diarrheagenic E. coli pathotypes strain. Echeveria extracts did not have any effect on viability and cytokine production of colorectal adenocarcinoma cells. Conclusions: Echeveria methanol extracts have a bacteriostatic effect on all diarrheagenic E. coli pathotypes strains, thus potentially they could be used as antibacterial agents on diarrheagenic E. coli pathotypes-contaminated products and on patients with diarrheagenic E. coli pathotypes infections.

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“…The major component of the extract of rose petals is kaempferol-3-O-glucoside, alongside with other kaempferol glycosides, and it has been shown to have antimicrobial and antioxidant effects [ 66 , 67 , 68 ]. The rose geranium extract, also rich in flavonoids (quercetin glycosides), had strong antimicrobial and antiviral activity in our study; our results are in agreement with earlier reports on the antimicrobial activity of geranium extracts [ 63 , 69 ] and quercetin derivatives [ 66 ].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Essential Oils and Extracts of Rose Geranium and Rose Petals as Natural Preservatives in Terms of Toxicity, Antimicrobial, and Antiviral Activity

Androutsopoulou

Christopoulou

Hahalis³

et al. 2021

Pathogens

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Essential oils (EOs) and extracts of rose geranium (Pelargonium graveolens) and petals of rose (Rosa damascena) have been fully characterized in terms of composition, safety, antimicrobial, and antiviral properties. They were analyzed against Escherichia coli, Salmonella enterica serovar Typhimurium, Staphylococcus aureus, Aspergillus niger, and Adenovirus 35. Their toxicity and life span were also determined. EO of P. graveolens (5%) did not retain any antibacterial activity (whereas at 100% it was greatly effective against E. coli), had antifungal activity against A. niger, and significant antiviral activity. Rose geranium extract (dilutions 25−90%) (v/v) had antifungal and antibacterial activity, especially against E. coli, and dose-dependent antiviral activity. Rose petals EO (5%) retains low inhibitory activity against S. aureus and S. Typhimurium growth (about 20−30%), antifungal activity, and antiviral activity for medium to low virus concentrations. Rose petals extract had significant antibacterial activity at dilutions of 25−90%, especially against E. coli and S. Typhimurium, antifungal, and the most potent antiviral activity. None of the EOs and extracts were toxic in dilutions of up to 5% and 90%, respectively. Finally, all materials had a life span of more than eight weeks. These results support the aspect that rose petals and rose geranium EOs, and extracts, have beneficial antimicrobial and antiviral properties and they can be used as natural preservatives.

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Flavonoids with antibacterial and antioxidant potentials from the stem bark of Uapaca heudelotti

Cited by 15 publications

References 20 publications

Phytochemical Screening, Antioxidant, Antibacterial, Antifungal Potential and in vivo Acute Toxicity of the Crude Extract of Cordia Rothii and Viola Serpens

Phytochemical Screening, Antioxidant, Antibacterial, Antifungal Potential and in vivo Acute Toxicity of the Crude Extract of Cordia Rothii and Viola Serpens

Bacteriostatic effect of Echeveria extracts on diarrheagenic E. coli pathotypes and non-cytotoxicity on human Caco-2 cells

Evaluation of Essential Oils and Extracts of Rose Geranium and Rose Petals as Natural Preservatives in Terms of Toxicity, Antimicrobial, and Antiviral Activity

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