Flavonoids through the eyes of a pharmacologist. Antioxidant and anti-inflammatory activities

Zverev, Yakov F.; Федорович, Зверев Яков

doi:10.17816/rcf1545-13

Cited by 13 publications

(4 citation statements)

References 57 publications

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“…Flavonoids are becoming more interesting as evidence accumulates about the beneficial effect of foods containing these compounds on human health. It is well known that flavonoids have antioxidant, antiinflammaroty, anticarcinogenic, neuroprotective, antidiabetic, antimicrobial, and antitrombotic activity, and their application facilitates the course of various diseases [1][2][3][4][5]. This is of special importance due to the high availability and relative low cost of dietary flavonoids.…”

Section: Introductionmentioning

confidence: 99%

Modern Nanocarriers as a Factor in Increasing the Bioavailability and Pharmacological Activity of Flavonoids

Zverev

Rykunova

2022

Appl Biochem Microbiol

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This review is devoted to modern systems of nanocarriers that ensure the targeted delivery of flavonoids to various organs and systems. Flavonoids have wide range of effects on the human body due to their antioxidant, anti-inflammatory, antitumor, antimicrobial, antiplatelet and other types of activity. However, the low bioavailability of flavonoids significantly limits their practical application. To overcome this disadvantage, serious efforts have been made in recent years to develop nanoscale carriers for flavonoids. This is particularly important in view of the known antitumor effect of these compounds, which allows them to target tumor cells without affecting surrounding healthy tissues. Nanocarriers provide increased penetration of biologicals into specific organs in combination with controlled and prolonged release, which markedly improves their effectiveness. This review summarizes data on the use of phytosomes, lipid-based nanoparticles, as well as polymeric and inorganic nanoparticles; their advantages and drawbacks are analyzed; the prospect of their use is discussed that opens new possibilities for the clinical application of flavonoids.

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Section: Introductionmentioning

confidence: 99%

Modern Nanocarriers as a Factor in Increasing the Bioavailability and Pharmacological Activity of Flavonoids

Zverev

Rykunova

2022

Appl Biochem Microbiol

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“…За умов нормального функціонування організму активність ензимів антиоксидантної системи (АОС) та інтенсивність вільнорадикальних процесів знаходяться у стані рівноваги. Вплив патогенних чинників може призводити до порушення роботи АОС та зміщення цієї рівноваги в бік утворення продуктів ПОЛ та ОМП, що в подальшому спричинює розвиток різноманітних патологій [2][3][4][5][6].…”

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Activity of free radical oxidation processes in rats with paracetamol hepatitis and correction with shiitake mushrooms thick extract

Herasymets

Фіра

Medvid

2021

Farm Zh

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The antioxidant defense system controls and inhibits all stages of free radical formation reactions, which start from their initiation and end with the formation of hydroperoxides and malonic dialdehyde. Disorders of the body's antioxidant defense system can be caused by both endogenous and exogenous factors and can lead to the oxidative stress development. For the purpose of the negative impact minimizing and correction of the existing disorders, both natural and synthetic origin antioxidants are used. Preference is given to antioxidants of natural origin, due to their mild action and minimal side effects. Shiitake mushrooms are known in China and Japan as a product that has nutritional and medicinal value, for thousands of years. They contain an extremely rich complex of various biologically active substances that can have antioxidant, hepatoprotective effect and influence on the liver diseases pathogenesis. The aim of the work was to investigate the effect of shiitake mushrooms thick extract on the activity of free radical processes and indicators of the antioxidant system under the conditions of paracetamol hepatitis in rats. The experimental work was being conducted on the white male rats, which were divided into 10 groups of 6 animals each. Acute hepatitis was simulated by intragastric administration of paracetamol in a dose of 1 250 mg/kg 1 time per day (for 2 days) as a suspension in 2% starch gel solution. We investigated the effect of shiitake mushrooms thick extract on the induced pathology, which was administered intragastrically 2 hours before the paracetamol introduction and daily after the lesion in a dose of 150 mg/kg of the rat’s body weight. Silibor was selected as the comparison drug, which was administered according to the same scheme like the investigated extract in a dose of 20 mg/kg of the animal’s body weight. Euthanasia was conducted on the 3rd, 7th and 10th day after the onset of the lesion. Liver homogenate and animal serum were examined. The effectiveness of shiitake mushrooms thick extract was evaluated under the conditions of the caused pathology by superoxide dismutase and catalase activity, as well as by the content of TBA-active and proteins oxidative modification products. An increasing of the TBA-active products content and the products of proteins oxidative modification in the serum and liver of animals after the toxic paracetamol exposure testifies to the liver damage and the development of acute hepatitis in rats. Decreased activity of antioxidant enzymes such as catalase and superoxide dismutase was also noted. An investigation, which was conducted by us, allowed us to reveal a positive effect of shiitake mushrooms thick extract on the activity of lipoperoxidation and oxidative modification of proteins under the conditions of white rats paracetamol lesion.

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“…У сучасній флорі України налічують понад 23 видів роду Achillea L. [1]. У науковій та народній медицині їх широко застосовують для прискорення загоєння ран, зупинення кровотеч різної етіології, як протизапальні, антигельмінтні засоби [2,3]. Види роду Achillea L. є фармакопейними, їх застосують в Україні, Британії, Швейцарії, Румунії, Швеції, Фінляндії.…”

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“…Флавоноїди -це найчисленніший клас природних поліфенольних сполук, яким властива різноманітна активність та нетоксичність [10,11]. Вони еволюційно пристосовані до організму людини, саме цим і зумовлена їх антиоксидантна, гемостатична, гепатопротекторна фармакологічна активність [2,7,9].…”

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The chemical composition of polyphenolic compounds Achillea micranthoides Klok. herbs

Duyun¹,

Мазулін²,

Мазулін³

et al. 2020

Farm Zh

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For obtain modern herbal remedies, medicinal plants containing flavonoids and hydroxycinnamic acids are promising. These polyphenolic compounds are characterized by structural diversity, non-toxicity, a wide range of pharmacological activity. An actual problem is the development of new modern instrumental research methods. In scientific and folk medicine the genus Achillea L. of the Asteraceae L. family are widely used to accelerate wound healing, stop bleeding of various etiologies, as anti-inflammatory and anthelmintic agents. The herb of Achillea micranthoides Klok. has theoretical and practical interest. The plant is distributed in the southern regions of the Black Sea and Mediterranean countries, Europe, Ukraine. A long growing season contributes to the accumulation of biologically active polyphenolic compounds from groups of flavonoids and hydroxycinnamic acids. The aim of the work was to study the composition of polyphenolic compounds (flavonoids and the hydroxycinnamic acids) in the herbs of the Achillea micranthoides Klok. during flowering (june-september). The object of research was herb of Achillea micranthoides Klok. Harvesting was carried out in south and oust regions of Ukraine during flowering (June–September, 2017). The investigation of polyphenolic compounds were performed by TLC and HPLC methods. HPLC analyzes were performed using an Agilent Technogies (Model 1100) (Japan). The chromatographic column ZORBAX-SB C-18 measuring 2.1×150 mm, filled with octadecylsilyl sorbent, with a grain diameter of 3.5 microns were used. The systems as the mobile phase: trifluoroacetic acid 0,2%, methanol anhydrous and a mixture of trifluoroacetic acid 0,2% with methanol 70% were used; wave length 313 nm, 350 nm. During the flowering period, the presence and quantitative content were established 8 flavonoids (up to 1,176 ± 0,122%) and 6 hydroxycinnamic acids (up to 0,807 ± 0,071%). The identified flavonoids are dominated by compounds: apigenin-7,4'-di-O-glucoside, quercetin-3-O-rutinoside, luteolin-6-C-glucoside, luteolin-7-O-β-D-glucopyranoside, apigenin-7-O-β-D-glucopyranoside. The highest content in the composition of hydroxycinnamic acids was found for chlorogenic and caffeic acids. The obtained results to be used for perspective modern herbal remedies from Achillea micranthoides Klok. herb with anti-inflammatory, antioxidative, haemostatic and hepatoprotective activities. The qualitative and quantitative determination methods of polyphenolic compounds in Achillea micranthoides Klok. herb may be used to the State Ukraine Pharmacopoeia monographs.

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Flavonoids through the eyes of a pharmacologist. Antioxidant and anti-inflammatory activities

Cited by 13 publications

References 57 publications

Modern Nanocarriers as a Factor in Increasing the Bioavailability and Pharmacological Activity of Flavonoids

Modern Nanocarriers as a Factor in Increasing the Bioavailability and Pharmacological Activity of Flavonoids

Activity of free radical oxidation processes in rats with paracetamol hepatitis and correction with shiitake mushrooms thick extract

The chemical composition of polyphenolic compounds Achillea micranthoides Klok. herbs

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