“…After absorption, lipophilic aglycones undergo metabolic transformation in the small intestine, liver, and colon. Conjugated products entering the systemic circulation after methylation, sulfation and glucuronization of flavonoids are devoid of the pronounced biological activity characteristic of aglycones in vitro [10,11]. As an example, the blood serum of healthy people, who received 240 mg of flavonolignane silybin, con-Abbreviations: AgNP, argentum-based nanoparticle; AuNP, aurum-based nanoparticle; EGCG, epigallocatechin-3-gallate; HEB, hematoencephalic barrier; GIT, gastrointestinal tract; MSN, silica-based nanoparticle; NLC, nanostructured lipid carrier; PAMAM, polyamidoamine; NS, nanosphere; PAMAM, polyamidoamine; PCL, polycaprolactone; PCR, polymerase chain reaction; PEG, polyethylene glycol; PLA, polylactic acid; PLGA, plyglycolic acid; PNP, polymer nanoparticle; PVP, polyvinylpirrolidone; RES, reticuloendothelial system; ROS, reative oxygen species; SLN, solid lipid nanoparticle.…”