Flavonoids, the compounds with anti-inflammatory and immunomodulatory properties, as promising tools in multiple sclerosis (MS) therapy: A systematic review of preclinical evidence

Bayat, Payam; Farshchi, Maral; Yousefian, Mozhdeh; Mahmoudi, Mahmoud; Yazdian‐Robati, Rezvan

doi:10.1016/j.intimp.2021.107562

Cited by 30 publications

(14 citation statements)

References 71 publications

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“…Third, fruits and vegetables contain abundant quantities of flavonoids, which contribute to plant color and protect against microbial infection 27 . The properties of flavonoids depend on the arrangement of hydroxyl, methoxy, and glycosidic side groups and the conjugation between the A- and B-rings 28 .…”

Section: Resultsmentioning

confidence: 99%

Traditional processing increases biological activities of Dendrobium offificinale Kimura et. Migo in Southeast Yunnan, China

Zhou

Zhao

Chen

et al. 2022

Sci Rep

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The orchid Dendrobium officinale grows throughout southeast China and southeast Asian countries and is used to treat inflammation and diabetes in traditional Chinese medicine. Tie pi feng dou is a well-known traditional Chinese medicine made from the dried D. officinale stems. Processing alters the physicochemical properties of TPFD; however, it is unclear how processing affects the quality and medicinal value of this plant. Here, we analyzed and compared the chemical composition of fresh stems of D. officinale and TPFD and explored possible explanations for the enhanced medicinal efficacy of processed D. officinale stems using qualitative and quantitative methods. To identify the components of FSD and TPFD, we used ultra-high-performance liquid chromatography combined with mass spectrometry in negative and positive ion modes and interpreted the data using the Human Metabolome Database and multivariate statistical analysis. We detected 23,709 peaks and identified 2352 metabolites; 370 of these metabolites were differentially abundant between FSD and TPFD (245 more abundant in TPFD than in FSD, and 125 less abundant), including organooxygen compounds, prenol lipids, flavonoids, carboxylic acids and their derivatives, and fatty acyls. Of these, 43 chemical markers clearly distinguished between FSD and TPFD samples, as confirmed using orthogonal partial least squares discriminant analysis. A pharmacological activity analysis showed that, compared with FSD, TPFD had significantly higher levels of some metabolites with anti-inflammatory activity, consistent with its use to treat inflammation. In addition to revealing the basis of the medicinal efficacy of TPFD, this study supports the benefits of the traditional usage of D. officinale.

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Section: Resultsmentioning

confidence: 99%

Traditional processing increases biological activities of Dendrobium offificinale Kimura et. Migo in Southeast Yunnan, China

Zhou

Zhao

Chen

et al. 2022

Sci Rep

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“…Moreover, oral administration of nobiletin effectively suppressed tumor formation and metastasis in the xenograft mice, and lowered the levels of NF-κB in the isolated tumors ( 34 ). It has been established that the anti-inflammatory activity of citrus flavonoids is closely associated with the structural properties of different flavonoids ( 35 ), and in this respect, it is speculated that the strong inhibitory capacities of tangeretin and nobiletin against IL-β and Cox-2 are correlated with the methoxy substituents at positions 5 and 8 ( 36 ). Consistent with the inhibitory effect of NO production, we speculate that the hydroxyl group may be associated with attenuating the inhibitory activity of PMFs on the expression of iNOS ( 36 ).…”

Section: Resultsmentioning

confidence: 99%

Comparative effects of five polymethoxyflavones purified from Citrus tangerina on inflammation and cancer

Chen

Gu²,

Tan³

et al. 2022

Front. Nutr.

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Although the Citrus tangerina cultivar “Dahongpao” (CTD) has been established as a rich source of polymethoxyflavones (PMFs) with anti-inflammatory and anti-cancer properties, their individual effects on cellular signaling remain to be elucidated. In this study, five major PMFs from the peel of CTD were isolated, including sinensetin, tetramethyl-O-scutellarin (5,6,7,4′-tetramethoxyflavone), nobiletin (5,6,7,8,3′, 4′-hexamethoxyflavone), tangeretin (5,6,7,8,4′-pentamethoxyflavone), and 5-demethylnobiletin (5-OH-6,7,8,3′,4′-pentamethoxyflavone). These PMFs were found to significantly (p < 0.05) inhibit the production of NO and biomarkers of chronic inflammation (TNF-α and IL-6). Additionally, they effectively suppressed mRNA biomarkers of acute inflammation (Cox-2 and iNOS), and to varying degrees promoted the activation of anti-inflammatory cytokines (IL-4, IL-13, TNF-β, and IL-10). Among the five PMFs, tangeretin was found to have a considerable anti-proliferative effect on tumor cell lines (PC-3 and DU145) and synergistically enhanced the cytotoxicity of mitoxantrone, partially via activation of the PTEN/AKT pathway. The findings of this study provide valuable insights into the activity of different PMF monomers and advance the understanding of the roles of PMFs in promoting apoptotic and anti-cancer effects.

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“…Fatty acids exert their inflammatory effects via the activation of the nuclear factor-kappa B signaling pathway, leading to the secretion of these proinflammatory cytokines [ 51 ]. Flavonoids are closely related to anti-inflammatory activity [ 52 ]. Both genistein and biochanin A significantly reduced the levels of free fatty acids in hyperlipidemic hamsters and obese rats [ 32 , 53 ].…”

Section: Discussionmentioning

confidence: 99%

The Hypolipidemic Effect of Dalbergia odorifera T. C. Chen Leaf Extract on Hyperlipidemic Rats and Its Mechanism Investigation Based on Network Pharmacology

Hui

Hu²,

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Objective. The aim of this study was to explore the hypolipidemic effect and mechanism of Dalbergia odorifera T. C. Chen leaf extract. Methods. The hypolipidemic effect of D. odorifera leaf extract was investigated using a hyperlipidemic rat model. Then, its mechanism was predicted using network pharmacology methods and verified using western blotting. Results. Compared with the levels in the model group, the serum levels of triglyceride (TG), total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-C) decreased significantly, whereas the serum level of high-density lipoprotein cholesterol (HDL-C) increased dramatically after treatment with the extract. The degrees of hepatocyte steatosis and inflammatory infiltration were markedly attenuated in vivo. Then, its hyperlipidemic mechanism was predicted using network pharmacology-based analysis. Thirty-five key targets, including sterol regulatory element-binding protein cleavage-activating protein (SCAP), sterol regulatory element-binding protein-2 (SREBP-2), 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR), low-density lipoprotein receptor (LDLR), and ten signaling pathways, were associated with hyperlipidemia. Finally, it was verified that the extract downregulated the protein levels of SCAP, SREBP-2, and HMGCR, and upregulated protein levels of LDLR. Conclusion. These findings provided additional evidence of the hypolipidemic effect of D. odorifera leaf extract.

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Flavonoids, the compounds with anti-inflammatory and immunomodulatory properties, as promising tools in multiple sclerosis (MS) therapy: A systematic review of preclinical evidence

Cited by 30 publications

References 71 publications

Traditional processing increases biological activities of Dendrobium offificinale Kimura et. Migo in Southeast Yunnan, China

Traditional processing increases biological activities of Dendrobium offificinale Kimura et. Migo in Southeast Yunnan, China

Comparative effects of five polymethoxyflavones purified from Citrus tangerina on inflammation and cancer

The Hypolipidemic Effect of Dalbergia odorifera T. C. Chen Leaf Extract on Hyperlipidemic Rats and Its Mechanism Investigation Based on Network Pharmacology

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